Estudo comparativo da eficácia clínica e microbiológica da associação de ciprof loxacina 0,3% e dexametasona 0,1%, versus gentamicina 0,3% e dexametasona 0,1%, no tratamento de conjuntivites bacterianas agudas

Alves, Mílton Ruiz; José, Newton Kara

doi:10.5935/0004-2749.19950086

Cited by 2 publications

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“…The mechanism of action of the fluoroquinolones helps to account for the low incidence of resistant microorganisms (1,3) . The fluoroquinolones have a broad spectrum of action (1)(2)(3)21) , and are stable drugs as marketed in the form of eye drops at a concentration of 3 mg/ml (1) . It is known that the susceptibility of anaerobic bacteria is greater to third-generation quinolones, such as lomefloxacin.…”

Section: Discussionmentioning

confidence: 99%

“…The antibacterial activity of fluoroquinolones, such as lomefloxacin, is mediated through inhibition of the bacterial enzyme DNA gyrase, resulting in failure to synthesize bacterial DNA. As a consequence, fluoroquinolones are bactericidal (1,9,11) . Topical instillation of lomefloxacin, as compared to other quinolones, achieved better intraocular penetration, leading to higher concentrations in the aqueous humor (10,(12)(13) .…”

Section: Introductionmentioning

confidence: 99%

“…The most frequent infections of the conjunctiva which are submitted to laboratory evaluation are due to bacteria, and an initial treatment with broadspectrum antibiotics is usually recommended after the clinical diagnosis and after scraping the site of infection (1)(2)(3) . Susceptibility tests for microorganisms isolated from ocular infections are recommended, since the results are useful not only in specific cases but also as epidemiological data (4)(5) .…”

Section: Introductionmentioning

confidence: 99%

“…Similar to other fluoroquinolones, lomefloxacin has a broad spectrum of action, including Gram-positive and -negative microorganisms. As a third-generation quinolone, it also has the advantage of being effective against some anaerobic bacteria (1)(2)(7)(8)(9)(10) . The antibacterial activity of fluoroquinolones, such as lomefloxacin, is mediated through inhibition of the bacterial enzyme DNA gyrase, resulting in failure to synthesize bacterial DNA.…”

Section: Introductionmentioning

confidence: 99%

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Microbiological efficacy of lomefloxacin and other drug's regarding microorganisms isolated from the human conjunctiva

Hofling-Lima¹,

Moeller²,

Yu³

et al. 2001

Arq. Bras. Oftalmol.

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Purpose: To evaluate and compare the in vitro susceptibility of human conjunctival bacterial isolates to various antimicrobial agents, including lomefloxacin, other fluoroquinolones (ciprofloxacin, norfloxacin, and ofloxacin), aminoglycosides (gentamicin, tobramycin, and amicacin), and cephalosporin (cephalothin). Methods: Antibiotic susceptibility tests conducted over a period of 27 months with 613 bacterial isolates from the conjunctiva were retrospectively analyzed. Results: In relation to the total number of positive isolates, the fluoroquinolones showed greater in vitro effectiveness than the other analyzed antibiotics. All bacterial isolates showed significantly higher susceptibility to ciprofloxacin than to lomefloxacin. Conclusion: The fluoroquinolones are not only equally effective against all conjunctival bacterial isolates, but they also show superior antimicrobial activity in comparison to aminoglycosides and cephalothin. These results suggest that fluoroquinolones, such as lomefloxacin, can be beneficially prescribed for conjunctival infections and also as prophylaxis in ocular surgery. Atividade biocida da lomefloxacina em relação aos microorganismos

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