The purpose of this research is to demonstrate, in an original study, the potentiality of the use of Cajueiro (Anacardium sp.) and Amescla (Trattinikia sp.), two low density tropical wood species, for producing OSB (Oriented strand boards), structural panels that replace plywood for several building purposes. In those panels, wood strands can be disposed in a specific direction or in random distribution, in order to reach the desirable mechanical properties. In this case, the strands were oriented by a separator to generate layers in mass proportion 20:60:20 (outer, inner and outer layers). Then these pre-panels went to a pre-pressing to form the mattress. Finally, they were pressed at 100°C, by 10 minutes, under 4.5MPa pressure, using castor oil based bicomponent polyurethane resin as adhesive. They were produced eight panels (four with Cajueiro e four with Amescla), with nominal dimensions 350mm length, 350mm width and 10mm thickness. Results showed that these wood species can be used to produce OSB, mainly considering values obtained in mechanical tests, that are superior to OSB produced in Brazilian enterprises and can be classified as OSB/4, as recommended by European standard EN 300. Research should continue to be developed in order to reach more adequate performance in swelling and water absorption.