Hematological reference ranges among healthy adults of Curitiba, PR, Brazil

Valdati, Kelis Daiane; Henneberg, Raílson; Nascimento, Aguinaldo José do

doi:10.5581/1516-8484.20110106

Cited by 2 publications

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“…Com relação á contagem total e diferencial dos leucócitos, no presente trabalho os resultados encontrados são semelhantes ao publicados por Van den Bossche para a contagem total e diferencial de leucócitos (VALDATI et al, 2011), o que comprova a estabilidade desta contagem em indivíduos normais.…”

Section: Discussionunclassified

Reference Range for CBC Obtained in Automated Analyzer Haematological Cell-Dyn Ruby.

Viana¹,

Henneberg²,

Silva³

2014

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Com o avanço tecnológico e o desenvolvimento de modernos equipamentos automatizados de células sanguíneas, os quais possuem diferentes metodologias para a obtenção dos índices hematológicos, é necessário que o laboratório clínico obtenha um intervalo de referência equipamento-específico. O objetivo do presente trabalho foi estabelecer intervalos de referência próprios para os hemogramas realizados no Hospital Angelina Caron, localizado na cidade de Campina Grande do Sul, região metropolitana de Curitiba. As amostras foram processadas no analisador hematológico Cell-Dyn Ruby, ABBOTTÒ. Foram analisadas amostras de sangue total de 195 indivíduos saudáveis, que foram atendidos no laboratório para a realização de exames de rotina. Em relação aos parâmetros referentes á série vermelha, os resultados obtidos são semelhantes a estudo similar realizado na cidade de Curitiba, publicado em 2011, com exceção do comportamento do RDW. A contagem total e diferencial dos leucócitos foi semelhante a outros trabalhos realizados com o mesmo fim, demonstrando a excelente performance analítica desta contagem, mesmo em equipamentos e populações diferentes. A contagem de plaquetas apresentou perfil semelhante a outros estudos, porém, o VPM (Volume Plaquetário Médio) demostrou intervalos maiores quando comparados a outros intervalos de referência já publicados.Os resultados obtidos devem ser utilizados com ressalvas, pois respeitam características próprias de instrumentação e população atendida, porém ilustra de maneira pratica a importância de estudos com este fim..

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Section: Discussionunclassified

Reference Range for CBC Obtained in Automated Analyzer Haematological Cell-Dyn Ruby.

Viana¹,

Henneberg²,

Silva³

2014

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“…Results of hematotoxicity in the two groups of workers exposed to benzene, separated by sex. Mean and reference range for hematology laboratory counts: Basophilis (×10 6 L −1 ): women 29.6 (0–99) and men 41.7 (0–125); Eosinophilis (×10 6 L −1 ): women 228.5 (56–682) and men 284.6 (65–940); Erythrocytes (× 10 12 L −1 ):women 4.7 (4.0–5.4) and men 5.2 (4.3–6.1); Hematocrit (L L −1 ): women 0.41 (0.35–0.46) and men 0.45 (0.38–0.52); Hemoglobin (g L −1 ): women 136.2 (118–154) and men 152.8 (127–177); Leukocytes (×10 9 L −1 ): women 6.7 (3.84–10.4) and men 6.7 (3.9–10.9); Lynphocytes (×10 6 L −1 ): women 2175.3 (1157–3500) and men 2223.2 (1265–3648); Monocytes (×10 6 L −1 ): women 455.1 (208–807) and men 503.2 (192–968); Neutrophils (×10 6 L −1 ): women 3777.3 (1804–6460) and men 3762.7 (1728–6820); Platelets (×10 9 L −1 ): 284.1 (175–421) and men 258.6 (163–399) [50]. …”

Section: Figurementioning

confidence: 99%

Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene

Costa‐Amaral

Carvalho

Santos

et al. 2019

IJERPH

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Environmental and occupational exposure to benzene from fuels is a major cause for concern for national and international authorities, as benzene is a known carcinogen in humans and there is no safe limit for exposure to carcinogens. The objective of this study was to evaluate the genotoxic effects of chronic occupational exposure to benzene among two groups of workers: filling station workers (Group I) and security guards working at vehicles entrances (Group II), both on the same busy highway in Rio de Janeiro, Brazil. Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalities, comet assay using the enzyme formamidopyrimidine DNA glycosylase (C-FPG), and methylation of repetitive element LINE-1, CDKN2B and KLF6 genes. Eighty-six workers participated: 51 from Group I and 35 from Group II. The B/T ratio was similar for both groups, but Group I had greater oscillation of benzene concentrations because of their work activities. No differences in ttMA and S-PMA, and no clinical changes were found between both groups, but linearity was observed between leukocyte count and ttMA; and 15% of workers had leukocyte counts less than 4.5 × 109 cells L−1, demanding close worker’s attention. No differences were observed between the two groups for THIOL, MDA, MCA, or nuclear abnormalities. A multiple linear relationship was obtained for the biomarkers MCA and C-FPG. A significant correlation was found between length of time in current job and the biomarkers C-FPG, MCA, GST, and MDA. Although both populations had chronic exposure to benzene, the filling station workers were exposed to higher concentrations of benzene during their work activities, indicating an increased risk of DNA damage.

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Hematological reference ranges among healthy adults of Curitiba, PR, Brazil

Cited by 2 publications

References 2 publications

Reference Range for CBC Obtained in Automated Analyzer Haematological Cell-Dyn Ruby.

Reference Range for CBC Obtained in Automated Analyzer Haematological Cell-Dyn Ruby.

Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene

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