Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives

Abstract

A new series of substituted pyrazolines (6-10) were synthesized in moderate to excellent yield by treatment of chalcones (1-5) with hydrazine monohydrate. The carbothioamide compounds (11)(12)(13)(14) were obtained in 65% to quantitative yield by treatment of chalcones (2, 4, and 5) either with thiosemicarbazide or with phenylisothiocyanate. All new compounds were characterized by various spectroscopic methods such as 1 H NMR, 13 C NMR, DEPT, COSY, HSQC spectroscopy, elemental analysis, and high resolution mass spectroscopy. The obtained compounds are currently under biological investigations, and the results will be reported elsewhere. KEYWORDS

A Smart and Efficient One‐Pot Green Synthesis of Novel 1, 2, 3‐Triazolyl Pyrazoline‐/Indazolyl‐Carbothioamide Hybrids under Solvent‐Free Grinding Strategy at Room Temperature

“…Though the literature provides various synthetic protocols for the synthesis of pyrazoline carbothioamides,,,, most of them show one or more shortcomings such as prolonged reaction time (more than 15 hrs), multi steps, harsh reaction conditions (reflux condition) and use of organic solvents. Hence, the development of new greener protocol for the synthesis of novel 1,2,3‐triazolyl pyrazoline‐/indazolyl‐carbothioamide hybrids becomes a noteworthy attempt.…”