A Smart and Efficient One‐Pot Green Synthesis of Novel 1, 2, 3‐Triazolyl Pyrazoline‐/Indazolyl‐Carbothioamide Hybrids under Solvent‐Free Grinding Strategy at Room Temperature

Abstract

A smart and straightforward route has been developed for the green synthesis of novel 1,2,3-triazolyl pyrazoline-/indazolylcarbothioamide hybrids from easily accessible starting materials for the first time via one-pot sequential four component reaction under solvent-free grinding protocol at room temper-ature. Notably, this protocol is meritorious in the sense that it is inexpensive, expeditious, devoid of tedious separation methods, environmentally benign and it involves mild reaction conditions affording good to excellent yields (84-97%) of the products.

Synthesis, spectral, crystal structure, drug‐likeness, in silico, and in vitro biological screening of halogen [Cl, Br] substituted N‐phenylbenzo[g]indazole derivatives as antimicrobial agents

“…The general synthesis route of the following compounds is described schematically in Scheme 1. (a) 3‐(4‐chlorophenyl)‐3,3a,4,5‐tetrahydro‐ N ‐phenylbenzo[ g ]indazole‐2‐carbothioamide (4CLPBIC), (b) 3‐(4‐bromophenyl)‐3,3a,4,5‐tetrahydro‐ N ‐phenylbenzo[ g ]indazole‐2‐carbothioamide (4BRPBIC), and (c) 3‐(3‐bromophenyl)‐3,3a,4,5‐tetrahydro‐ N ‐phenylbenzo[ g ]indazole‐2‐carbothioamide (3BRPBIC) were synthesized based on the literature report [31]. At room temperature, α ‐tetralone (1, 1.0 mmol), 4‐Chlorobenzaldehyde/4‐Bromobenzaldehyde/3‐Bromobenzaldehyde ( 2a/2b/2c , 1.0 mmol), and solid NaOH (20 mol %), hydrazine hydrate (3, 1.2 mmol) were mixed thoroughly and ground for 15–20 min with the help of a mortar and pestle.…”

An elegant and efficient synthesis of heterocycles integrated with bis‐N‐acyl pyrazoline and bis‐1, 2, 3‐triazole via a green synthetic methodology

“…As a prelude to this, in our lab, we have synthesized various bioactive hybrid heterocycles namely, 1,2,3-triazole-2-aminopyrimidines [24], 1,2,3-triazolyl pyrazolinyl/indazolyl carbothioamides [25], 1,2,3-triazolyl-1,4-dihydropyridines [26], and 1,2,3-triazolyl pyridine/ cyanopyridines [27] from readily accessible starting materials through sustainable synthetic approaches.…”