The orchestrated
network of octahedron shaped Cu organic framework
is developed via a simple aging protocol, and the partial cation swap
reactions between Cu and Ni nodes in the Cu2-paddlewheel
units of Cu-MOF generates Cu-Ni-MOF with similar octahedron morphology.
Exploiting Cu-Ni-MOF as a template, the uniformly disseminated and
tightly pinned CuO/NiO spherical nanoparticles with hierarchical
carbon are developed under controlled thermal and atmospheric conditions.
The MOFs and metal oxide-carbon nanocomposites coated over the cello
tapes (CTs) are exploited as electrochemical sensor probes for nonenzymatic
glucose sensing. It adequately swamps the impediments of prevailing
glucose sensor probes including time depletion, high cost, monotonous
electrode cleaning and modification processes, and use of swellable
inactive binders. Owing to the subsistence of an interconnected network
and synergistic effect of bimetallic oxides, CuO/NiO-C expedites the
considerable electrocatalytic behavior toward glucose sensing. Furthermore,
the fabricated CuO/NiO-C/CT exercises the diagnosis
of glucose in human serum samples. These flexible electrochemical
sensor probes acquiesce the device to sustain deformation with high
efficacy, opening an appealing access for the evolution of cost-efficient,
binder-free, reliable, flexible, and eco-friendly sensing platforms
for the development of futuristic electrochemical sensor devices.
Arsenic trioxide (AsO) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind AsO toxicity. Since liver is the major organ for xenobiotic metabolism, it is always under stress. Antioxidant vitamins such as L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) have been proposed to have beneficial effects against a variety of pathological conditions and are known by their free radical scavenging properties. The present study evaluates the curative efficacy of L-AA and α-TOC against AsO toxicity using immortalized human Chang liver cells. Our results suggest that L-AA (100 µM) and α-TOC (50 µM) recovered AsO (10 µM) cytotoxicity. Furthermore, AsO treatment showed an increase in lipid peroxidation and depletion in antioxidant status, mitochondrial trans membrane potential and values of total antioxidant capacity. Cotreatment of antioxidant vitamins with AsO resulted in a significant reversal of oxidative stress markers. Our findings substantiate the effect of antioxidant vitamins in protecting the hepatocytes from oxidative stress which may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2) mediated upregulation of Bcl2 (B-cell lymphoma 2) expression.
Hematite nanoparticles have been prepared from Moringa oleifera leaf extracts. Phytochemicals are derived from plant extracts which act as a stabilizing and capping agent as well as a surfactant. This green route protocol is attractive owing to its speed, reliability, and ecofriendly and cost-effective qualities. The synthesized iron oxide nanoparticles were subjected to three different calcination temperatures (500, 600, and 700°C). The crystallinity nature and phase purity have been confirmed by powder X-ray diffraction (PXRD). Optical properties have been studied by UV-visible (UV-vis) and diffuse reflectance spectroscopy (DRS). A very narrow bandgap was observed, and absorbance was observed at the visible region. Photoluminescence spectra have exhibited a multicolor emission band from the near UV to visible region due to defect centers (F centers). EDX (energy dispersive X-ray spectrum) has given information on the stoichiometric ratio of Fe and O. The functional groups which are responsible for nanoparticle formation have been identified by Fourier transformed infrared spectroscopy (FTIR), surface morphology transformation has been illustrated by scanning electron microscopy (SEM) studies, and VSM measurements have exhibited a hysteresis curve that shows the weak and strong ferromagnetic behavior in nature at RT. TEM micrographs have confirmed that particles are in the nanorange, matching the results from the XRD report. The SAED pattern gives information on the polycrystalline nature of hematite nanoparticles. TG-DSC characterization revealed phase transition, decomposition, and weight loss information. Frequency-dependent electrical properties were studied. Here, we report what the present studies have revealed: that hematite nanopowder prepared from the green route is environmentally friendly, takes a short time to prepare, is an economical and promising candidate material for electromagnetic devices and ferromagnet manufacturing, and is a photocatalyst in water treatment applications without adding additives (H2O2).
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