Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide

Kumar, L. Shiva; Kollur, Shiva Prasad; Revanasiddappa, H. D.

doi:10.5155/eurjchem.2.3.394-403.232

Cited by 43 publications

(11 citation statements)

References 45 publications

(41 reference statements)

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“…[24,25] The powdered root samples were dissolved to a concentration of 1000 mg/mL in ethanol. Solutions of different concentrations (1000, 500, 250, 125 and 62.5 mg/mL) were prepared by the serial dilution technique.…”

Section: Determination Of Free-radical-scavenging Activitymentioning

confidence: 99%

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Karahan

Avşar

Özyiğit

et al. 2016

Biotechnology & Biotechnological Equipment

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In this study, the antimicrobial and antioxidant activities of root methanolic extracts of Glycyrrhiza glabra var. glandulifera (Waldst. & Kit.) Boiss. (Fabaceae) were investigated. Plant samples were collected from different habitats in the East Mediterranean part of Turkey. The plant extracts were evaluated for antimicrobial activities against nine bacterial and two yeast strains using discdiffusion and minimum inhibitory concentration methods. The antioxidant activity was determined by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The antimicrobial assays indicated that the plant root extracts were more effective against Gram-positive bacteria than against Gramnegative ones. In addition, the extracts had higher antimicrobial effect against Candida species than against bacteria. The extracts showed good antioxidant activity, with a median inhibitory concentration (IC 50 ) in the range of 588 § 0.86 mg/mL to 2190 § 1.73 mg/mL. Results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and biological activity in the natural licorice populations of. This study also supported the traditional use of licorice and as well as suggested that it may also be its beneficial role in the treatment of other infections. The obtained results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and the biological activity in the natural licorice populations.

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Section: Determination Of Free-radical-scavenging Activitymentioning

confidence: 99%

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Karahan

Avşar

Özyiğit

et al. 2016

Biotechnology & Biotechnological Equipment

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“…The stock solution of CT-DNA was prepared in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7, which gave 260 / 280 nm of ca. 1.8-1.9, indicating that the DNA was sufficiently devoid of protein [36], and the concentration of DNA was determined from its absorption intensity at 260 nm ( 260 = 6600 M −1 cm −1 ) [37]. All the stock solutions were stored at 4 ∘ C and used within four days.…”

Section: Dna-binding Experimentsmentioning

confidence: 99%

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Savithri

Kumar

Vivek³

et al. 2018

International Journal of Spectroscopy

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A bidentate (N- and O-) imine-based ligand(L1)and its metal complexes of types [CuII(L1)2](C1), [CuII(L1)(Phen)](C2), [CoIII(L1)2](C3), and [CoIII(L1)(Phen)](C4)(L1= 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes.In vitrobioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively byKbandKsvvalues which revealed a higher binding affinity for C2and C4as compared to C1and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

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“…The experimental results showed that these complexes could cause the cleavage of DNA. The different DNA cleavage efficiency of these complexes may be due to the different binding affinity of the complexes to DNA[74,75].To investigate the mechanism involved in DNA cleavage in the presence of MPA, complexes (1-3) were incubated in the presence of different reactive oxygen scavengers like DMSO, KI, sodium azide and L-histidine(Fig. 10 a-c).…”

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confidence: 99%

Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

Thamilarasan

Sengottuvelan

Sudha

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide

Cited by 43 publications

References 45 publications

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

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