Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats

Abstract

In this study, the antimicrobial and antioxidant activities of root methanolic extracts of Glycyrrhiza glabra var. glandulifera (Waldst. & Kit.) Boiss. (Fabaceae) were investigated. Plant samples were collected from different habitats in the East Mediterranean part of Turkey. The plant extracts were evaluated for antimicrobial activities against nine bacterial and two yeast strains using discdiffusion and minimum inhibitory concentration methods. The antioxidant activity was determined by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The antimicrobial assays indicated that the plant root extracts were more effective against Gram-positive bacteria than against Gramnegative ones. In addition, the extracts had higher antimicrobial effect against Candida species than against bacteria. The extracts showed good antioxidant activity, with a median inhibitory concentration (IC 50 ) in the range of 588 § 0.86 mg/mL to 2190 § 1.73 mg/mL. Results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and biological activity in the natural licorice populations of. This study also supported the traditional use of licorice and as well as suggested that it may also be its beneficial role in the treatment of other infections. The obtained results indicated that different environmental conditions in each habitat might affect the contents of chemical compounds and the biological activity in the natural licorice populations.

Ecological variability of the phenolic compounds of Olea europaea L. leaves from natural habitats and cultivated conditions

“…The factors that may influence the content, quality and quantity of these active substances mainly rest upon the type of plant habitat, the predominance of certain abiotic factors in the habitat, the season of the year as well as upon the presence or absence of unfavourable conditions in which the plant grows [6][7][8][9]. All plant organs contain flavonoids; however, their quantity varies depending on the plant species or ecological and genetic factors [10][11][12][13][14][15].…”

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

“…Glycyrrhizin inhibits free radical reactions mediated by iron, free iron in hemoglobin, and carbonyl formation in hemoglobin that are manifested in diabetes. Hydromethanolic G. glabra root extract has been reported to have numerous polyphenolic compounds that revealed marked antioxidant efficacy in vitro and in vivo [51,52]. For instance, licochalcones B and D demonstrated their potential antioxidant efficacy by preventing microsomal lipid peroxidation and, thus, inhibiting red blood cells from oxidative hemolytic effects.…”

Evaluation of Liquorice (Glycyrrhiza glabra) for Enhancing Shelf-Life of Ghee against Oxidative Deterioration

“…Extraction and identification of natural antioxidants from liquorice (Glycyrrhiza glabra) was done by El-sherif et al, (2011) and found that liquorice extract (ethanolic) contained 353.93 mg per 100g (gallic acid). The DPPH-radical-scavenging activity of the methanolic extracts of licorice from different habitats determined by Karahan et al, (2016). The IC 50 values of the extracts were found to be between 588±0.86 µg/ml and 2190±1.73 µg/ml.…”

“…Liquorice is useful in conventional and naturopathic medicine for both mouth ulcers and peptic ulcers. It is also useful to treat cough, bronchitis, ulceration of urinary tract and anaemia (Rajurkar and Hande, 2011;Karahan et al, 2016). Some limited work is reported for utilization of their extracts prepared in organic solvents in ghee (Patel et al, 2013).…”

“…More than 300 flavonoids have been isolated from Glycyrrhizin species. These flavonoids belong to various types, including flavanones or flavanols, chalcones, isoflavans, isoflavenes, flavones or flavonols, isoflavones and isoflavanones (Karahan et al, 2016). Flavonoid rich fractions include eliquirtin, isoliquertin liquiritigenin and rhamnoliquirilin and five new flavonoids-glucoliquiritinapioside, prenyllicoflavone A, shinflavanone, shinpterocarpinand 1-methoxyphaseolin 3,4 isolated from dried roots (Visavadiya et al, 2009).…”