Perfil das anomalias congênitas em nascidos vivos de Tangará da Serra, Mato Grosso, 2006-2016*

Silva, Juliana Herrero da; Terças, Ana Cláudia Pereira; Pinheiro, Laura Castelo Branco; França, Giovanny Vinícius Araújo de; Atanaka, Marina; Schüler‐Faccini, Lavínia

doi:10.5123/s1679-49742018000300017

Cited by 12 publications

(13 citation statements)

References 8 publications

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“…Congenital anomalies are developmental disorders of embryonic origin, and may be structural, functional or metabolic changes in the fetus present at birth or that manifest after several years [1][2][3][4]. Inherited or acquired, their causes may be associated with genetic, environmental, physical, chemical, biological factors, or multifactorial when they are due to more than one of these factors [1,2,5]. In the majority of cases, the etiology of the congenital anomalies remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Those of genetic origin have been investigated more and the chromosomes and malformations with Mendelian inheritance have been covered [1,6]. Those dependent on environmental factors or gene-environment interactions are more difficult to recognize because cases caused by teratogens are still poorly studied, especially in developing countries such as Brazil [1,2,6]. Some studies in Brazil show that the estimated frequency of congenital anomalies is 2% to 3% of live births [2,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Those dependent on environmental factors or gene-environment interactions are more difficult to recognize because cases caused by teratogens are still poorly studied, especially in developing countries such as Brazil [1,2,6]. Some studies in Brazil show that the estimated frequency of congenital anomalies is 2% to 3% of live births [2,[6][7][8]. In developing countries, such as Brazil, there is little research on the prevalence of these congenital malformations.…”

Section: Introductionmentioning

confidence: 99%

“…As of 1999, a field was included in the NLB, coded according to Chapter XVII of the 10th Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10), which allowed the notification of congenital anomalies, making it possible, when duly completed, to evaluate their frequency and the nature of the events. The aim of this was to develop reliable health and surveillance indicators, in order to facilitate the planning of health D DAVID PUBLISHING policies, especially for children, which made SINASC an important tool for monitoring congenital anomalies in Brazil [1,2,[6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…The registration of information in the hospital can be hampered by inadequate throughput, especially when different people collect and complete the NLB data. Therefore, it is recommended that the NLB be completed prior to the moment of discharge of the mother and by a single person [2]. However, there are studies that affirm that the NLB is completed by more than one member of staff 7 .Failure to correctly enter the data may occur due to a lack of training of the staff responsible or failure to perceive the importance of the correct completion [8].…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Congenital Anomalies in the State of Amazonas-Brazil for the Period 2008 to 2017

Souza¹,

Fantin²

2019

JPP

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There are few studies on the frequency of congenital anomalies in Brazil, particularly in the state of Amazonas. Therefore, the aim of this study was to investigate the number of live births with congenital anomalies in Amazonas, in the period 2008-2017, based on the Live Birth Information System (SINASC), as well as to discuss the relevance of the professionals being trained for the correct completion of the notice of live birth. In the study period, of the 773,313 live births in Amazonas, 4,593 were diagnosed with some type of congenital anomaly, according to DATASUS. This corresponds to a prevalence of 5.9 cases per 1,000 live births. The most frequent cases were congenital deformities of the musculoskeletal system, with 23% of the reports, congenital deformity of the feet, with 16%, and other congenital malformations, with 15% of the registrations. The need for investments in the training and qualification of professionals was observed, so that they can act, in a qualified way, in the cycle of diagnosis, registration and support for families, since they have not been trained to deal with this new reality. The importance is emphasized of continuing the research in the field of genetic diseases in Amazonas, in order to assist the individuals and families affected, as well as supporting the decisions related to the planning and implementation of public policies directed toward the issue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequency of Congenital Anomalies in the State of Amazonas-Brazil for the Period 2008 to 2017

Souza¹,

Fantin²

2019

JPP

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Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

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High prevalence of gastroschisis in Brazilian triple side border: A socioenvironmental spatial analysis

2021

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This research investigated the spatial association between socioenvironmental factors and gastroschisis in Brazilian triple side border. A geographic analysis for gastroschisis prevalence was performed considering census sector units using Global Moran Index, Local Indicator of Spatial Association Analysis and Getis Ord statistics. Sociodemographic factors included rate of adolescent and parturients over 35 years; population with no income and above 5 minimum wages; rate of late prenatal; and proximity to power transmission lines. Logistic regression models were applied to verify the association between socio-environmental factors and prevalence of gastroschisis. No global spatial correlation was observed in the distribution of gastroschisis (Moran´s I = 0.006; p = 0.319). However, multiple logistic regression showed census sectors with positive cases had higher probability to power transmission lines proximity (OR 3,47; CI 95% 1,11–10,79; p = 0,031). Yet, spatial scan statistic showed low risk for gastroschisis in southern city region (OR = 0; p = 0.035) in opposite to power transmission lines location. The study design does not allow us to attest the causality between power transmission lines and gastroschisis but these findings support the potential exposure risk of pregnant to electromagnetic fields.

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Perfil das anomalias congênitas em nascidos vivos de Tangará da Serra, Mato Grosso, 2006-2016*

Cited by 12 publications

References 8 publications

Frequency of Congenital Anomalies in the State of Amazonas-Brazil for the Period 2008 to 2017

Frequency of Congenital Anomalies in the State of Amazonas-Brazil for the Period 2008 to 2017

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

High prevalence of gastroschisis in Brazilian triple side border: A socioenvironmental spatial analysis

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