Oral lichen planus and HCV infection

Tenório, Jefferson Rocha; Camargo, Alessandra Rodrigues de; Lemos, Celso Augusto; Ortega, Karem L.

doi:10.4322/acr.2020.210

Cited by 5 publications

(3 citation statements)

References 26 publications

(30 reference statements)

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“…The lesion response indicates the healing and improvement outcome which is as follows: complete response (CR): lack of visible lesion confirmed by clinical evaluation\ and no symptoms by patient-self reported and the remission of all atrophic/erosive lesions regardless of any persisting hyperkeratotic lesions; partial response (PR): at least 20% reduction in size of the lesion but no complete remission of atrophic/erosive areas and symptoms; no response (NR): < 20% reduction in size of the lesion or no changes from the baseline condition [77].…”

Section: Lesion Response Indicesmentioning

confidence: 99%

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Hanna

Dalvi²,

Tomov

et al. 2023

Journal of Biophotonics

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Section: Lesion Response Indicesmentioning

confidence: 99%

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Hanna

Dalvi²,

Tomov

et al. 2023

Journal of Biophotonics

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“…Studies of the oral cavity in chronic liver diseases, in particular HCV, are of great interest to clinicians, since pathological processes developing in the liver usually lead to oral mucosa disorders [ 5 ]. The oral cavity can reflect liver dysfunction in many ways: gingival bleeding, increased vulnerability to bruising, petechiae, oral soreness, cheilitis and crusted perioral rash [ 4 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study

Azatyan

Yessayan

Sargsyan³

et al. 2022

IJERPH

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The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group—e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response.

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“…Other drugs have been implicated such as diuretics, oral hypoglycemic agents, gold salts, penicillamine, beta-blockers, and antiretroviral drugs for the treatment of HIV (10). A possible association between LP and infection with HIV and hepatitis C virus (20)(21) has been suggested, but it could be related to zidovudine or ketoconazole therapy for HIV infection (19) or modern therapy for patients with chronic liver disease that includes interferon-gamma and ribavirin drugs often considered a cause for triggering lichenoid reactions (1). Researchers have found that contact of dental restorative materials with oral tissue may be associated with the development of lichenoid reactions that clinically and histologically resemble to OLP but have an identifiable etiology.…”

Section: Introductionmentioning

confidence: 99%

The Photodynamic Treatment of Oral Lichen Planus: A Literature Review

Azzouzi

Harti

2021

Integr J Med Sci

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Lichen planus (LP) is a chronic, relapsing, non-infectious inflammatory disease affecting the skin and mucous membranes. The exact origin of oral lichen planus (OLP) is not well known. Complete spontaneous healing is rare. The treatment of oral lichen planus is palliative, and there is no curative treatment so far, which is a therapeutic challenge for practitioners. The goals of treatment are the control of pain, signs, and symptoms. Local corticosteroids remain the first-line treatment. In case of failure of drug therapy, other treatments can be considered, such as photodynamic therapy. Material and methods: Our work was carried out using the PubMed, ScienceDirect, and EBSCO search engines to explore the literature on the efficacy of photodynamic therapy in the treatment of lichen planus. Conclusion: Photodynamic therapy appears to have some effect in the treatment of OLP in adult patients. However, further randomized controlled trials with a long follow-up period, standardized PDT parameters, and comparison of PDT efficacy with steroid therapy are warranted to obtain firm conclusions in this regard.

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Oral lichen planus and HCV infection

Cited by 5 publications

References 26 publications

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study

The Photodynamic Treatment of Oral Lichen Planus: A Literature Review

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