Anti-Cancer and Anti-Proliferation Activity of Ethyl Asetat Extract From Ant Nest (Myrmecodia pendans) in Burkitt’s Lymphoma Cancer Cells

Achmad, Mahmud; Horax, Sherly; Ramadhany, Sri; Rieuwpassa, Irene Edith; Sari, Melyanti; Handayani, Hendrastuti; Singgih, Marhamah F.; Sugiharto, Sumintarti

doi:10.4034/pboci.2019.191.29

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Many assays have been used to evaluate the toxicity activities of Myrmecodia species that associated with the potential of anticancer activity. Some crude extracts and compounds showed the inhibitory activity against various in vitro cancer cell lines (Table 2) [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]. Besides, Suharyanto and Purwono reported that M. pendens had effective anticancer activity in vivo model series.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

Dirgantara

Insanu

Fidrianny

2022

Open Access Maced J Med Sci

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BACKGROUND: The Myrmecodia genus belongs to the Rubiaceae family, which has the characteristic of an epiphytic plant. This genus spread from Malaysia, through the Philippines, Sumatra, Borneo, Java, New Guinea (Papua), Cape York to the Solomon Islands and Pacific region. It has been empirically proven to treat gout, inflammation, muscle pain relief, strengthen the body’s immunity, and cancer treatment. AIM: This article reviewed the scientific work about the Myrmecodia genus concerning their traditional uses, phytochemical compounds, and pharmacological activities of Myrmecodia. METHODS: The sources were from the scientific literature online database, including Science Direct, PubMed, and Google Scholar between 1978 and 2021. Furthermore, 112 articles were collected, while 61 full-text were assessed for eligibility. RESULTS: The Myrmecodia extract has many pharmacological activities, namely antioxidant, antibacterial, cytotoxic, and anticancer. CONCLUSION: Moreover, this review may be used as scientific literature for the next investigations on the genus Myrmecodia, especially regarding pharmacological properties such as in vitro and in vivo studies and isolation of the active compounds.

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Section: Cytotoxic Activitymentioning

confidence: 99%

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

Dirgantara

Insanu

Fidrianny

2022

Open Access Maced J Med Sci

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“…Burkitt's lymphoma is among most common cancers worldwide (Al-Attar et al, 1979;Achmad et al, 2019). Like all cancers, conventional treatment for lymphomas with immunotherapy and chemotherapy often lack efficacy due to the development of cancer resistance to the compounds.…”

Section: Introductionmentioning

confidence: 99%

Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

Albaayit

Khan

Abdullah

2021

Natural Volatiles and Essential Oils

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Zerumbone (ZER), a natural compound has been extracted from Zingiber zerumbet with known pharmacological activities. The aim was to determine the anti-human Burkitt's lymphoma (Raji) cell effect of ZER. The 3-(4,5-dimethylthiazol-2-yl)-2,5,diphenyltetrazolium bromide (MTT) assay was used to determine cytotoxic effect while the Annexin-V-fluorescein isothiocyanate/propidium iodide-PI flow cytometric assays was used to determine apoptotic effect of ZER on the human Burkitt's lymphoma (Raji) cell (ATCC CCL-86) cell line. The expressions of Bax, Bcl-2, and c-Myc genes were determined via real-time PCR. ZER suppressed the proliferation of Raji cells with a 48 h IC50 value of 5.1 μg/mL. Treated Raji cells also underwent late apoptosis especially after treatment with 100 μg/mL ZER. The apoptotic effect of ZER is associated with increase in Bax and decrease in Bcl-2 and c-Myc gene expressions. These results suggest that ZER inhibited the proliferation of Raji cells through the modification of apoptosis-related gene expressions. Therefore, ZER has potential as a candidate for the treatment of Burkitt's lymphoma.

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RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT’S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)

Achmad

Ramadhany

2019

J. Phys.: Conf. Ser.

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Introduction: Burkitt’s lymphoma (LB) is a tumor with high malignancy and rapid cell growth and originates from B-cell lymphoma. LB is usually found in children in endemic areas with dengue fever and HIV-AIDS with low socioeconomic levels. Objective: This research aims to analyze resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkiit’s lymphoma using flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans). Material and Methods: The study was conducted in a pure laboratory experimental method using burkitt’s lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: Resistivity of protein expression of protein kinase-B (Akt), transcription factor of nuclear factor-kappa B (NF-κB), and apoptosis induction (Caspace -3,-9) showed increased protein expression was significantly obstacles and prove that the ethyl acetate fraction flavonoid inhibits translocation and activation of transcription pathway NF-κB and growth factors that induces the phosphorylation of Akt signal transduction pathway, and apoptosis induction (Caspace -3,-9). Conclusion: Flavonoid fraction of ethyl acetate from ant nest (Myrmecodia pendans) resistivity of protein kinase-B (Akt), NF-κB transduction obstacles, and apoptosis induction (Caspace -3, -9) as anti-proliferation and anti-cancer of burkitt’s lymphoma.

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Anti-Cancer and Anti-Proliferation Activity of Ethyl Asetat Extract From Ant Nest (Myrmecodia pendans) in Burkitt’s Lymphoma Cancer Cells

Cited by 3 publications

References 5 publications

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

RESISTIVITY OF PROTEIN KINASE-B (AKT), NF-κB TRANSDUCTION OBSTACLES, AND APOPTOSIS INDUCTION (CASPACE -3, -9) AS ANTI-PROLIFERATION AND ANTI-CANCER OF BURKITT’S LYMPHOMA USING FLAVONOID FRACTION OF ETHYL ACETATE FROM ANT NEST (MYRMECODIA PENDANS)

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