Metabolic syndrome in children

Sinaiko, Alan R.

doi:10.2223/jped.2214

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…In addition, some cardiovascular risk markers representative of MS, such as hypertension, impaired fasting glucose, and T2DM, are rare in children (23,30), a finding confirmed in the present case series.…”

Section: Discussionsupporting

confidence: 85%

Leptin as a predictor of metabolic syndrome in prepubertal children

Madeira

Bordallo

Rodrigues

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Leptin has been suggested as a potential biomarker of cardiovascular risk. This paper aims to ascertain, based on a sample of prepubertal children, which serum leptin value best suited to identify metabolic syndrome (MS). Subjects and methods: This observational, cross-sectional study recruited children from the outpatient pediatrics clinic, with the purpose of validating serum leptin level cutoffs to identify MS. All obese and overweight children who met eligibility criteria were included in the study, as was a sample of normal-weight children. The sample underwent clinical assessment and blood fasting glucose, lipid profile, insulin, and leptin were measured. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. The association between MS and leptin was assessed using logistic models to predict MS. Results: A total of 65 normal weight, 46 overweight, and 164 obese children were analyzed (160 boys, 115 girls; age: 93.7 ± 17.8 months). The most appropriate leptin cutoff was 13.4 ng/mL (sensitivity 67.6%; specificity 68.9%; accuracy 72.1%). The logistic model indicated that leptin levels above 13.4 ng/dL were significantly associated with MS and that, for every 1 ng/dL increase in leptin levels, the odds of MS increase by 3% (p = 0.002; OR 1.03; 95% CI 1.01-1.05). Conclusions: Leptin may be a useful biomarker of cardiovascular risk in prepubertal children, with an optimal cutoff of 13.4 ng/mL. Identification of potential new risk markers for cardiovascular disease in children could contribute to the development of preventive strategies.Arch Endocrinol Metab. 2017;61(1):7-13

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Section: Discussionsupporting

confidence: 85%

Leptin as a predictor of metabolic syndrome in prepubertal children

Madeira

Bordallo

Rodrigues

et al. 2017

Arch. Endocrinol. Metab.

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“…Childhood obesity is a global public health problem that affects children in underdeveloped and developing countries, and is increasing at a rapid rate, especially in developing economies 30,31 . Currently, there is an ongoing debate about the anthropometric measurements that should be used to diagnose MetS in children 32,33,34 . Thus, this study contributes to this discussion and presents two different WC measurements as strong MetS predictors.…”

Section: Discussionmentioning

confidence: 99%

Waist circumference percentile curves as a screening tool to predict cardiovascular risk factors and metabolic syndrome risk in Brazilian children

et al. 2018

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The goals of this study were to develop reference values for waist circumference (WC) in Brazilian children between 6-10 years old and to evaluate the WC performance in predicting cardiovascular risk factors and metabolic syndrome (MetS) in children. This is a population-based epidemiological cross-sectional study, in which 1,397 children participated, with a 6-10 years old probability sampling and from public and private schools in the city of Uberaba, Minas Gerais State, Brazil. WC was measured at the waist narrowest point (WC1) and at the umbilicus level (WC2). Blood samples and blood pressure were collected to determine the MetS diagnosis. There was a significant effect of age (p = 0.001), anatomical point (WC1 vs. WC2, p = 0.001) and sex-anatomical point interaction (p = 0.016) for WC. Smoothed sex- and age-specific 5th, 10th, 25th, 50th, 75th, 90th and 95th percentile curves of WC1 and WC2 were designed by the LMS method. WC was accurate to predict MetS, for all ages [area under the ROC curve (AUC) > 0.79 and p < 0.05], regardless of sex. This study presented percentile curves for WC at two anatomical points in a representative sample of Brazilian children. Furthermore, WC was shown to be a strong predictor of cardiovascular risk factors and MetS in children.

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“…3 No México, de acordo com a Pesquisa Nacional de Saúde e Nutrição de 2012 (Ensanut), a prevalência combinada de sobrepeso e obesidade foi de 34,4% em crianças em idade escolar (cinco-11 anos) e 35% em adolescentes (12 e 19 anos); 4 essas prevalências estão ligeiramente acima das relatadas em 2006. 6,7 Da mesma forma, estão associados ao início precoce de diabetes mellitus e de processos ateroscleróticos que predispõem jovens a doenças cardiovasculares. 6,7 Da mesma forma, estão associados ao início precoce de diabetes mellitus e de processos ateroscleróticos que predispõem jovens a doenças cardiovasculares.…”

Section: Introductionunclassified

Leisure‐time physical activity and cardiometabolic risk among children and adolescents

Cárdenas‐Cárdenas

Burguete-García

Estrada-Velasco

et al. 2015

Jornal de Pediatria (Versão em Português)

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Objective: To assess the effect of Leisure-time physical activity (LTPA) on cardiometabolic risk by nutritional status in Mexican children and adolescents. Methods: This was a cross-sectional study conducted with 1,309 participants aged between 5 and 17 years. Nutritional status was classified according to the BMI Z-score by age and gender. A previously validated questionnaire was used to evaluate LTPA; a cardiometabolic risk score was calculated. Multiple linear regression analysis was performed to assess the effect of LTPA on cardiometabolic risk. Results: After adjusting for risk factors, mild LTPA were positively associated with cardiometabolic risk score (␤ Mild vs. Intense LTPA : 0.68; 95% CI: 0.18 to 1.18; p for trend = 0.007). This association became stronger when estimated for overweight (␤ Mild vs. Intense LTPA : 1.24; 95% CI: 0.24 to 2.24; p for trend = 0.015) and obese participants (␤ Mild vs. Intense LTPA : 1.02; 95% CI: 0.07 to 1.97; p for trend = 0.045). Conclusion: Mild LTPA was positively associated with cardiometabolic risk in overweight and obese children and adolescents. Given the emerging childhood obesity epidemic in Mexico, these results may be useful in the design of strategies and programs to increase physical activity levels in order to achieve better health. M, et al. Leisure-time physical activity and cardiometabolic risk among children and adolescents. J Pediatr (Rio J). 2015;91:136---42.

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Metabolic syndrome in children

Cited by 14 publications

References 20 publications

Leptin as a predictor of metabolic syndrome in prepubertal children

Leptin as a predictor of metabolic syndrome in prepubertal children

Waist circumference percentile curves as a screening tool to predict cardiovascular risk factors and metabolic syndrome risk in Brazilian children

Leisure‐time physical activity and cardiometabolic risk among children and adolescents

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