Essential Oils from Croton Species: Chemical Composition, in vitro and in silico Antileishmanial Evaluation, Antioxidant and Cytotoxicity Activities

Morais, Selene Maia de; Cossolosso, Danyelle S.; Silva, Antonio A. S.; Moraes, Manoel Odoríco de; Teixeira, Maria Jânia; Campello, C.C.; Bonilla, Oriel Herrera; Paula, Valdir Ferreira de; Vila-Nova, Nadja Soares

doi:10.21577/0103-5053.20190155

Cited by 15 publications

(13 citation statements)

References 26 publications

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“…The antioxidant activity of the EO from C. ferrugineus showed SC 50 values of 901 ± 20 for ABTS and >1000 for DPPH assays. Morais et al [ 26 ] reported a moderate antioxidant activity of the EO from four C. species, expressed as SC 50 in μg/mL, C. argyrophylloides 12.55 ± 0.43, C. jacobinensis 22.11 ± 3.24, C. nepetifolius 24.96 ± 6.87, and C. sincorensis 80.59 ± 18.98. Rossi et al [ 27 ] reported lower SC 50 for the EO from C. lechleri .…”

Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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Croton ferrugineus Kunth is an endemic species of Ecuador used in traditional medicine both for wound healing and as an antiseptic. In this study, fresh Croton ferrugineus leaves were collected and subjected to hydrodistillation for extraction of the essential oil. The chemical composition of the essential oil was determined by gas chromatography equipped with a flame ionization detector and gas chromatography coupled to a mass spectrometer using a non-polar and a polar chromatographic column. The antibacterial activity was assayed against three Gram-positive bacteria, one Gram-negative bacterium and one dermatophyte fungus. The radical scavenging properties of the essential oil was evaluated by means of DPPH and ABTS assays. The chemical analysis allowed us to identify thirty-five compounds representing more than 99.95% of the total composition. Aliphatic sesquiterpene hydrocarbon trans-caryophyllene was the main constituent with 20.47 ± 1.25%. Other main compounds were myrcene (11.47 ± 1.56%), β-phellandrene (10.55 ± 0.02%), germacrene D (7.60 ± 0.60%), and α-humulene (5.49 ± 0.38%). The essential oil from Croton ferrugineus presented moderate activity against Candida albicans (ATCC 10231) with an MIC of 1000 μg/mL, a scavenging capacity SC50 of 901 ± 20 µg/mL with the ABTS method, and very strong antiglucosidase activity with an IC50 of 146 ± 20 µg/mL.

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Section: Discussionmentioning

confidence: 99%

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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“…Globulol is also found in varying concentrations in EOs of various plants that belong to different families such as Myrtaceae, including Eucalyptus spp., with a rate of 5.3% extracted from the leaves and white kunzea ( Kunzea ambigua (Sm.) Druce) by 11.2% from leaf oil; the family of Asteraceae, including Vassoura ( Baccharis dracunculifolia DC), with a rate of 2.5–14.5% from leaf oil; the family of Cyperaceae such as Piri-piri ( Cyperus articulatus L.) by 3.2–4.6% from rhizomes oil; and the family of Valerianaceae, e.g., Valerian ( Valeriana officinalis L.) at a rate of 2.1% from root oil [ 38 , 50 , 51 ].…”

Section: Natural Sources Of Essential Oilsmentioning

confidence: 99%

“…Spathulenol is a viscous colorless tricyclic sesquiterpene alcohol with antileishmanial impacts (C 15 H 24 O: 1aR, 4aR, 7S, 7aR, 7bR)–1, 1, 7-Trimethy l-4-methylidene-1a, 2, 3, 4a, 5, 6, 7a, 7b-octahydrocyclopropa -h- azulen-7-ol) that is a major constituent of EOs extracted from the fresh leaves of croton species ( C. argyrophylloides , C. jacobinensis , and C. sincorensis ) at 42.54%, 15.41%, and 9.58%, respectively [ 51 ]. It occurs as the main component in the oil originating from the male and female specimen leaves of B. semiserrata DC, achieving 50.75 and 42.65%, respectively [ 52 ].…”

Section: Natural Sources Of Essential Oilsmentioning

confidence: 99%

Exploring the Roles of Dietary Herbal Essential Oils in Aquaculture: A Review

Dawood

Basuini

Yılmaz

et al. 2022

Animals

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The aquaculture sector is one of the main activities contributing to food security for humanity around the globe. However, aquatic animals are susceptible to several farming stressors involved in deteriorated growth performance, reduced productivity, and eventually high mortality rates. In some countries still, antibiotics and chemotherapies are comprehensively applied to control biotic stressors. Aside from the apparent benefits, the continuous usage of antibiotics develops bacterial resistance, deteriorates bacterial populations, and accumulates these compounds in the aquatic environment. Alternatively, environmentally friendly additives were used to avoid the direct and indirect impacts on the aquatic ecosystem and human health. In aquaculture, medicinal herbs and extracts are extensively used and approved for their growth-promoting, anti-inflammatory, and antioxidative properties. Herbal essential oils contain many bioactive components with powerful antibacterial, antioxidative, and immunostimulant potentials, suggesting their application for aquatic animals. Essential oils can be provided via diet and can benefit aquatic animals by improving their well-being and health status. The use of essential oils in aquafeed has been studied in a variety of aquatic animals to determine their beneficial roles and optimum doses. The outputs illustrated that herbal essential oils are exciting alternatives to antibiotics with prominent growth promotion, antioxidative, and immunostimulant roles. Herein, we reviewed the beneficial roles of essential oils in aquaculture. This review also aims to describe trends in herbal essential oils use, mainly in commercial fish species, and to analyze different factors that affect essential oils’ efficacy on the growth performance, antioxidative, and immune responses of finfish species.

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“…23 It is an anesthetic and a vasodilator agent, possessing antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. 24 Selene et al 25 reported that spathulenol was identified as a major constituent in the essential oils of four Croton species, which displayed good antioxidant activity. According to them, spathulenol was active against the enzyme Leishmania infantum trypanothione reductase, showing…”

Section: Dcm Fraction Of a Squamosa Fruit Podmentioning

confidence: 99%

Chemical Characteristics and Biological Activities of Annona squamosa Fruit Pod and Seed Extracts

Adesanwo¹,

Akinloye²,

Otemuyiwa³

et al. 2020

Journal of Exploratory Research in Pharmacology

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Background and objectives: Annona squamosa (A. squamosa) is a medicinal plant, used in ethnomedicinal treatment of various ailments. However, there is a dearth of information on the chemical constituents of this plant's fruit pod and chemical parameters of the seed oil. The objectives of this study were, therefore, to determine the chemical characteristics and biological activities of extracts of the fruit pod and seed oil of A. squamosa.Methods: Crude methanol extract of the dried and pulverized fruit pod were partitioned using n-hexane and dichloromethane (DCM), the fractions concentrated in-vacuo to yield n-hexane and DCM fractions of the fruit pod. The n-hexane extract of the dried ground seed was concentrated in vacuo to afford the seed oil. The fractions and the seed oil were subjected to gas chromatography-mass spectroscopy (GC-MS) analysis. The seed oil was characterized for chemical properties using standard methods. The seed oil, crude methanol extract of seed pod and fractions were assayed for antibacterial properties using both Gram-positive and Gram-negative bacteria. The seed oil was also examined for antioxidant activity. Results:The results from chemical analyses of the seed oil indicated that acid value, iodine value, saponification value and total phenol were 1.91 (as % oleic acid), 109.8 g I 2 /kg, 204.8 g KOH/kg and 36.2 mg gallic acid equivalent (GAE)/kg, respectively. GC-MS analysis revealed the presence of 14, 8 and 15 compounds in n-hexane and DCM fractions of the fruit pod and seed oil, respectively. Of the compounds identified, octadec-9-enoic acid, 9,10-dehydroisolongifolene and androsterone were the most abundant. The extracts displayed broad spectrum antibacterial activity against the 13 bacterial strains tested, except for Bacillus polymyxa, Enterococcus faecalis and Bacillus cereus, which were resistant to the n-hexane and DCM fractions of the fruit pod. Conclusions:The findings in this study indicated that the extracts and oil of A. squamosa contain bioactive compounds which have antibacterial and antioxidant properties, and the oil could be applied both as industrial and edible oil.

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Essential Oils from Croton Species: Chemical Composition, in vitro and in silico Antileishmanial Evaluation, Antioxidant and Cytotoxicity Activities

Cited by 15 publications

References 26 publications

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Exploring the Roles of Dietary Herbal Essential Oils in Aquaculture: A Review

Chemical Characteristics and Biological Activities of Annona squamosa Fruit Pod and Seed Extracts

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