Chemical Characteristics and Biological Activities of Annona squamosa Fruit Pod and Seed Extracts

Adesanwo, Julius K.; Akinloye, Akinola A.; Otemuyiwa, Israel Olusegun; Akinpelu, David A.

doi:10.14218/jerp.2020.00019

Cited by 6 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained IC 50 values are in good agreement with those obtained for a different part of A. squamosa 40 . The IC 50 is lower than the 1.33 mg.mL -1 reported for seed oil 41 . In addition, the results showed that it outperforms EO from the leaf of its peers A. muricata (244.8 μg.mL -1 ) 42 .…”

Section: Dpph Assaycontrasting

confidence: 55%

Storage Effect on the Gc-MS Profiling and Antioxidant Activities of Essential Oils From Leaves of Annona Squamosa L.

et al. 2022

View full text Add to dashboard Cite

Aim and objective: Medicinal plants, their biological activities, and their phytochemical contents are important for finding safe and potent new compounds for therapeutic use. In order to investigate the chemical contents and to evaluate the storage effect on the antioxidant activity of Lebanese Annona squamosa (AS) leaf essential oil, the current study was undertaken. Methods: Shade-dried leaves of AS were taken from Batroun (Lebanon), and the essential oil (EO) was extracted by hydrodistillation. The gas chromatography-mass spectrometry (GC-MS) technique was used to analyze the composition of the EO. Concerning the antioxidant activity, two different methods namely radical scavenging activity (DPPH test) and ferric reducing antioxidant power (FRAP) were used. Results: A total of 21 compounds were identified. The majority of the identified compounds belong to sesquiterpenoids. β-elemene (11.39 -14.14 %) and β-carophyllene (10.15 – 15.56 %) were the most abundant components. On the other hand, the storage of the plant materials containing the EOs or the EOs themselves leads to a loss in the volatile compounds, which is reflected in the bioactivity as shown in the results of the antioxidants assays. The EOs demonstrated antioxidant activities with IC50 lower than 9 μg.mL-1. DPPH test and FRAP test exhibited a strong positive correlation (r=0.99). Conclusion: The obtained results suggest that EO extracts from AS have an antioxidant to protect people. Thus, the EO of fresh samples of AS can have interesting applications in versatile areas such as the pharmaceutical and food industries. Peer Review History: Received: 27 April 2022; Revised: 11 June; Accepted: 29 June, Available online: 15 July 2022 Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com Similar Articles: GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS

show abstract

Section: Dpph Assaycontrasting

confidence: 55%

Storage Effect on the Gc-MS Profiling and Antioxidant Activities of Essential Oils From Leaves of Annona Squamosa L.

et al. 2022

View full text Add to dashboard Cite

show abstract

“…They included 36 acetogenins identified for the first time in A. muricata (Figure S1) and six identified for the first time from the genus Annona (Figure S2). The other 106 acetogenins were previously detected in this plant [1,6,[11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Characterization Of the Phytochemical Constituentsmentioning

confidence: 80%

LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of Annona muricata

Abdallah,

Al-Saleem,

Abdel-Mageed

et al. 2023

Molecules

View full text Add to dashboard Cite

Annona muricate is a tropical plant that is well-known for its edible fruit of therapeutic interest. LCMS/MS analyses were applied to identify phytoconstituents of the ethanolic extract of the whole fruits and the aqueous extract of the edible fruit part, in addition to the investigation of their anticancer properties against Ehrlich ascites carcinoma (EAC) in male albino mice. LCMS/MS analyses resulted in the identification of 388 components, representing a wide array of classes of compounds, including acetogenins as the major constituents, alkaloids, flavonoids, and phenolics. Among them, four compounds were tentatively characterized as new compounds (1–4), including an acid derivative, protocatechuic-coumaroyl-quinic acid (1), and three flavonoid derivatives, dihydromyricetin galloyl hexoside (2), apigenin gallate (3), and dihydromyricetin hexouronic acid hexoside (4). Induction with EAC cells resulted in abnormalities in the gene expression of pro-apoptotic genes (Bax and caspase-3) and anti-apoptotic gene (Bcl-2) in the tumor mass. Moreover, microscopic, histopathological, and immune-histochemical examinations of the tumor mass and liver tissues exhibited extensive growth of malignant Ehrlich carcinoma cells and marked hydropic degeneration of hepatocytes and infiltration by tumor cells to liver tissue with marked inflammatory reaction. These abnormalities were markedly ameliorated aftertreatment of EAC mice with A. muricata extracts.

show abstract

In Silico Analysis of the Annona Squamosa L. Seed (Custard Apple) Derived Phytocompounds Against Neurological Disorders

Mondal,

Islam,

Saha

et al. 2024

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

View full text Add to dashboard Cite

Chemical Characteristics and Biological Activities of Annona squamosa Fruit Pod and Seed Extracts

Cited by 6 publications

References 26 publications

Storage Effect on the Gc-MS Profiling and Antioxidant Activities of Essential Oils From Leaves of Annona Squamosa L.

Storage Effect on the Gc-MS Profiling and Antioxidant Activities of Essential Oils From Leaves of Annona Squamosa L.

LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of Annona muricata

In Silico Analysis of the Annona Squamosa L. Seed (Custard Apple) Derived Phytocompounds Against Neurological Disorders

Contact Info

Product

Resources

About