IRIDOIDES, TRITERPENOS E OUTROS CONSTITUINTES DAS CASCAS DO CAULE E FLORES DE Tabebuia caraiba BIGNONIACEAE

Abstract

D (4), 7-O-E-p-coumaroyljiofuranaldehyde (5), three known iridoids, including one iridoid glucoside, jioglutin D (1), rehmaglutin D (6), 6-O-E-p-coumaroylcatalpol (7). From the flowers were obtained six triterpenes, betulinic acid (8), olean-12-en-3-one (9), β-amyrin (10), oleanolic acid (11), ursolic acid (12), 3-O-E-p-coumaroylursolic acid (13), 2α-hydroxyursolic acid (14), 6β,19α-dihydroxyursolic acid (15), and one phenylethanoid, tyrosol (16), in addition to β-sitosterol, β-sitosterol-3-O-β-D-glucopyranoside and β-sitosterol-3-O-β-D-(6´-O-acyl)-glucopyranoside and E-p-coumaric acid. The structures of the isolated compounds were established on the basis of 1D and 2D NMR spectroscopic techniques. The chemical profile of the trunk bark of the plant was determined by HPLC/DAD/HRESIMS and did not present a good correlation with the phytochemical study. It did not detect most of the isolated substances and allowed to propose the presence of some non-isolated compounds.

Characterization of Promising Cytotoxic Metabolites from Tabebuia guayacan Hemsl.: Computational Prediction and In Vitro Testing

“…The isolated compounds were identified using a variety of spectroscopic methods, including: UV, HRMS, 1 H-NMR, and DEPT-Q NMR analyses as well as Co-TLC with authentic samples, and data comparison with the published literature. The isolated compounds were identified as; β-sitosterol ( 1 ) [ 22 ], ursolic acid ( 2 ) [ 23 , 24 ], corosolic acid ( 3 ) [ 25 ], 3- O - trans-p -coumaroylcrosolic acid ( 4 ) [ 23 , 26 ], 3,6,19 trihydroxy-ursolic acid ( 5 ) [ 27 ], β-sitosterol 3- O -β-glucoside ( 6 ) [ 28 ], quercetin ( 7 ) [ 29 ], luteolin ( 8 ) [ 30 ], quercetin-3- O -glucoside ( 9 ) [ 31 ], quercetin 3- O - β -xyloside ( 10 ) [ 32 , 33 ],4-hydroxybenzoic acid ( 11 ) [ 34 ], 4-methoxy benzoic acid ( 12 ) [ 34 ], 3,4-dihydroxybenzoic acid ( 13 ) [ 35 ], p -coumaric acid ( 14 ) [ 36 ], rutin ( 15 ) [ 37 ], and luteolin-7- O -β-glucoside ( 16 ) [ 38 ].…”

SKRINING FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN TIGA JENIS TABEBUYA (Tabebuia spp.)

“…Hasil penelitian esktrak daun T. roseo-alba positif mengandung metabolit sekunder terpenoid sesuai dengan penelitian sebelumnya. Ekstrak bunga T. rosea mengandung metabolit sekunder hepakosan yang tergolong fitokimia steroid dan terpenoid (Madhumitha et al, 2015), ekstrak kulit batang dan bunga T. caraiba mengandung metabolit sekunder asam oleanolik dan betulin yang tergolong fitokimia steroid dan terpenoid (Soares et al, 2006;Soares et al, 2020). Terpenoid merupakan metabolit sekunder terbesar dan paling beragam secara struktural yang berasal dari sumber alam (Isah et al, 2019), sedangkan steroid adalah golongan metabolit sekunder yang berasal dari kolestrol dan memiliki fungsi biologis yang beragam (Rahman et al, 2017).…”