COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTINOCICEPTIVA EM MODELO ANIMAL DO ÓLEO ESSENCIAL DE Myrcia rostrata DC. (MYRTACEAE)

Silva, Aline do Nascimento; Bomfim, Horácio Freitas; Magalhães, Acsa Oliveira; Rocha, M. L.; Lucchese, Angélica Maria

doi:10.21577/0100-4042.20170274

Cited by 11 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The microbiocidal action of EO from M. glomerata leaves was evidenced only for S. aureus and C. albicans strains, and the other tested strains showed only bacteriostatic action, except for B. subtilis and S. epidermidis that were not inhibited. A study carried out with EO from M. sylvatica leaves observed a bactericidal effect only for the gram-positive strain S. aureus, which corroborates our study, and bacteriostatic for S. epidermidis and E. faecalis (Silva 2015).…”

Section: )supporting

confidence: 91%

Analysis of the chemical constituents of Myrcia glomerata G.Burton & E.Lucas leaves and assessment of their antimicrobial, antioxidant, and antibiofilm potential against pathogenic microorganisms

Batista,

Bandeira,

Laskoski

et al. 2024

Cad. Pedagógico

View full text Add to dashboard Cite

The Myrtaceae family plays a significant role in the Angiosperm landscape in Brazil, standing out as one of the most relevant. Within this context, the genus Myrcia ranks as the fourth largest, and its plant extracts and essential oils from these species are recognized as a valuable source of plant bioactives. In this context, Myrcia glomerata, popularly known as guamirim, stands out. Despite belonging to the Myrtaceae family, there is a lack of detailed research on its biological activities and chemical composition. The phytochemical investigation of the different plant extracts: ethanolic (EE), methanolic (ME), hexane (HE), acetone (AE), ethyl acetate (EAE) and dichloromethane (DE) revealed the presence of saponins, free steroids, alkaloids, anthocyanins, anthocyanidins, flavones, flavonols, xanthones, chalcones, aurones, flavononols and tannins, leading to the quantification of phenolic compounds (flavonoids, tannins, and alkaloids). The essential oil of the leaves, identified by gas chromatography coupled to mass spectrometry (GC-MS) identified 29 compounds, corresponding to 97.54% of the total area of the essential oil of M. glomerata. The main compounds found were sesquiterpenes, Elemicin (76.85%), Elixene (3.99%), E-caryophyllene (2.25%). EE showed the best antimicrobial potential, with concentrations ranging from 0.39 to 25 mg.mL-1, with Staphylococcus aureus and Proteus mirabilis strains being more susceptible in EE, ME and AE, showing 98.72%, 96.23% and 88.60% antioxidant activity, respectively. As for the antibiofilm potential, ME showed the greatest biomass reduction (90.53%) for Salmonella enterica Typhimurium, with cell viability of 9.02%. These results demonstrate the potential of EE and ME extracts from M. glomerata, representing a possible source of natural bioactives to be used in pharmaceuticals for the control of resistant microorganisms.

show abstract

Section: )supporting

confidence: 91%

Analysis of the chemical constituents of Myrcia glomerata G.Burton & E.Lucas leaves and assessment of their antimicrobial, antioxidant, and antibiofilm potential against pathogenic microorganisms

Batista,

Bandeira,

Laskoski

et al. 2024

Cad. Pedagógico

View full text Add to dashboard Cite

show abstract

“…This left 127 records in full text. Among these, two had to be excluded because the text was in Chinese (Li et al, 1991;Chen et al, 2011) and one was excluded because it was written in Spanish (Do Nascimento Silva et al, 2018). After full text screening, 30 studies were included in qualitative analysis: 40 studies were not available in full text and 54 were excluded because they did not meet inclusion criteria because of species used, route of administration, composition, or lack of compliance with animal welfare regulations.…”

Section: Selection Process and Data Collectionmentioning

confidence: 99%

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

et al. 2021

View full text Add to dashboard Cite

Background: The demand for essential oils (EOs) has been steadily growing over the years. This is mirrored by a substantial increase in research concerned with EOs also in the field of inflammatory and neuropathic pain. The purpose of this present systematic review and meta-analysis is to investigate the preclinical evidence in favor of the working hypothesis of the analgesic properties of EOs, elucidating whether there is a consistent rational basis for translation into clinical settings.Methods: A literature search has been conducted on databases relevant for medical scientific literature, i.e., PubMed/MEDLINE, Scopus, and Web of Science from database inception until November 2, 2020, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses.Results: The search was conducted in order to answer the following PICOS (participants/population, interventions, comparisons, outcomes, and study design) question: are EOs efficacious in reducing acute nociceptive pain and/or neuropathic pain in mice experimental models? The search retrieved 2,491 records, leaving 954 studies to screen after the removal of duplicates. The title and abstract of all 954 studies were screened, which left 127 records to evaluate in full text. Of these, 30 articles were eligible for inclusion.Conclusion: Most studies (27) assessed the analgesic properties of EOs on acute nociceptive pain models, e.g. the acetic acid writhings test, the formalin test, and the hot plate test. Unfortunately, efficacy in neuropathic pain models, which are a more suitable model for human conditions of chronic pain, had fewer results (only three studies). Moreover, some methodologies raised concerns in terms of the risk of bias. Therefore, EOs with proven efficacy in both types of pain were corroborated by methodologically consistent studies, like the EO of bergamot, which should be studied in clinical trials to enhance the translational impact of preclinical modeling on clinical pain research.

show abstract

“…A determinação da atividade antinociceptiva em camundongos induzida por óleo essencial de Myrcia Rostrata Dc., espécie pertencente à família Myrtaceae, não apresentou letalidade, nem indícios de toxicidade animal, também não houve perda de peso (Silva et al, 2018).…”

Section: Aspectos éTicosunclassified

Potencial Genotóxico do Extrato Metanólico de Psidium guineense Sw (Araçá verdadeiro) em Células da Mucosa Oral

Silva

Cunha

Medeiros

et al. 2020

RSD

View full text Add to dashboard Cite

The present research seeks to perform the analysis of the genotoxic potential of the methanolic extract of the plant Psidium (P.) guineense Sw, popularly known as ‘Araçá Verdadeiro’, against cells in the oral cavity. The donor's oral mucosa cells were exposed ex vivo to the methanolic extract of P. guineense in concentrations (50, 100, 500 and 1000 µg/mL) for 30 minutes, the cell pellet smear was made and subsequent fixation on slides stained with 2% Giemsa. The analysis was done using an optical microscope, the whole experiment carried out in triplicate. The data reveal that even at high concentrations (500 and 1000 µg/mL) of the methanolic extract of P. guineense Sw. Cell toxicity is considered low with a percentage of normal cells (94.5% to 94%) compatible with the negative control. Therefore, the methanolic extract, belonging to the species P. guineense Sw. has the bioactive potential that can be explored through the possible application of this compound as a phytotherapic, however more studies must be performed to better understand the toxicity profile of this product.

show abstract

COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTINOCICEPTIVA EM MODELO ANIMAL DO ÓLEO ESSENCIAL DE Myrcia rostrata DC. (MYRTACEAE)

Cited by 11 publications

References 0 publications

Analysis of the chemical constituents of Myrcia glomerata G.Burton & E.Lucas leaves and assessment of their antimicrobial, antioxidant, and antibiofilm potential against pathogenic microorganisms

Analysis of the chemical constituents of Myrcia glomerata G.Burton & E.Lucas leaves and assessment of their antimicrobial, antioxidant, and antibiofilm potential against pathogenic microorganisms

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

Potencial Genotóxico do Extrato Metanólico de Psidium guineense Sw (Araçá verdadeiro) em Células da Mucosa Oral

Contact Info

Product

Resources

About