COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTINOCICEPTIVA EM MODELO ANIMAL DO ÓLEO ESSENCIAL DE Myrcia rostrata DC. (MYRTACEAE)

Silva, Aline do Nascimento; Bomfim, Horácio Freitas; Magalhães, Acsa Oliveira; Rocha, M. L.; Lucchese, Angélica Maria

doi:10.21577/0100-4042.20170274

Cited by 9 publications

(4 citation statements)

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“…This left 127 records in full text. Among these, two had to be excluded because the text was in Chinese (Li et al, 1991;Chen et al, 2011) and one was excluded because it was written in Spanish (Do Nascimento Silva et al, 2018). After full text screening, 30 studies were included in qualitative analysis: 40 studies were not available in full text and 54 were excluded because they did not meet inclusion criteria because of species used, route of administration, composition, or lack of compliance with animal welfare regulations.…”

Section: Selection Process and Data Collectionmentioning

confidence: 99%

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

et al. 2021

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Background: The demand for essential oils (EOs) has been steadily growing over the years. This is mirrored by a substantial increase in research concerned with EOs also in the field of inflammatory and neuropathic pain. The purpose of this present systematic review and meta-analysis is to investigate the preclinical evidence in favor of the working hypothesis of the analgesic properties of EOs, elucidating whether there is a consistent rational basis for translation into clinical settings.Methods: A literature search has been conducted on databases relevant for medical scientific literature, i.e., PubMed/MEDLINE, Scopus, and Web of Science from database inception until November 2, 2020, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses.Results: The search was conducted in order to answer the following PICOS (participants/population, interventions, comparisons, outcomes, and study design) question: are EOs efficacious in reducing acute nociceptive pain and/or neuropathic pain in mice experimental models? The search retrieved 2,491 records, leaving 954 studies to screen after the removal of duplicates. The title and abstract of all 954 studies were screened, which left 127 records to evaluate in full text. Of these, 30 articles were eligible for inclusion.Conclusion: Most studies (27) assessed the analgesic properties of EOs on acute nociceptive pain models, e.g. the acetic acid writhings test, the formalin test, and the hot plate test. Unfortunately, efficacy in neuropathic pain models, which are a more suitable model for human conditions of chronic pain, had fewer results (only three studies). Moreover, some methodologies raised concerns in terms of the risk of bias. Therefore, EOs with proven efficacy in both types of pain were corroborated by methodologically consistent studies, like the EO of bergamot, which should be studied in clinical trials to enhance the translational impact of preclinical modeling on clinical pain research.

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Section: Selection Process and Data Collectionmentioning

confidence: 99%

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

et al. 2021

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“…A determinação da atividade antinociceptiva em camundongos induzida por óleo essencial de Myrcia Rostrata Dc., espécie pertencente à família Myrtaceae, não apresentou letalidade, nem indícios de toxicidade animal, também não houve perda de peso (Silva et al, 2018).…”

Section: Aspectos éTicosunclassified

Potencial Genotóxico do Extrato Metanólico de Psidium guineense Sw (Araçá verdadeiro) em Células da Mucosa Oral

Silva

Cunha

Medeiros

et al. 2020

RSD

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The present research seeks to perform the analysis of the genotoxic potential of the methanolic extract of the plant Psidium (P.) guineense Sw, popularly known as ‘Araçá Verdadeiro’, against cells in the oral cavity. The donor's oral mucosa cells were exposed ex vivo to the methanolic extract of P. guineense in concentrations (50, 100, 500 and 1000 µg/mL) for 30 minutes, the cell pellet smear was made and subsequent fixation on slides stained with 2% Giemsa. The analysis was done using an optical microscope, the whole experiment carried out in triplicate. The data reveal that even at high concentrations (500 and 1000 µg/mL) of the methanolic extract of P. guineense Sw. Cell toxicity is considered low with a percentage of normal cells (94.5% to 94%) compatible with the negative control. Therefore, the methanolic extract, belonging to the species P. guineense Sw. has the bioactive potential that can be explored through the possible application of this compound as a phytotherapic, however more studies must be performed to better understand the toxicity profile of this product.

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“…Species of this genus demonstrated in vitro inhibitory activity of key diabetes targets, such as α-amylase and α-glucosidase (Oliveira & Pereira, 2015;González et al, 2016;Lima et al, 2018), and in addition some species showed hypoglycemic effects in vivo (Pepato et al, 1993;Miura et al, 2006;Vareda et al, 2014). The genus also has other medicinal properties: Myrcia tomentosa showed antimicrobial activities (Sa et al, 2017), Myrcia rostrata showed antinociceptive effects (Silva et al, 2018), Myrcia bella, Myrcia fallax, and Myrcia guianensis presented cytotoxic and antioxidant properties (Santos et al, 2018). The species Myrcia hatschbachii D. Legrand is a native and endemic tree from Brazil, with confirmed occurrences in the states of the South region and Atlantic Forest domain (BFG, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of α-glucosidase, pancreatic lipase, and antioxidant property of Myrcia hatschbachiiD. Legrand containing gallic and ellagic acids

Gatto¹,

Oliveira²,

Rech³

et al. 2021

BLACPMA

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Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, the aim of this work was to investigate the inhibitory activity of α-glucosidase and pancreatic lipase in the crude extract (EBF) and in the ethyl acetate fraction (FFA) of Myrcia hatschbachii, as well as to identify isolated phenolic compounds and to evaluate the antioxidant property and preliminary in vitro toxicity against Artemia salina. EBF (IC50: 3.21 μg/mL) and FFA (IC50: 1.14 μg/mL) showed inhibitory activity superior to acarbose (IC50: 193.65 μg/mL). In addition, they showed inhibitory effects of pancreatic lipase (IC50: 556.58 μg/mL for EBF and 532.68 μg/mL for FFA), antioxidant potential, absence of preliminary toxicity and presence of gallic andellagic acids in FFA. The relevant results in the inhibition of α-glucosidase and pancreatic lipase motivate new studies for the development of herbal medicines that assist in the treatment of diabetic patients.

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COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTINOCICEPTIVA EM MODELO ANIMAL DO ÓLEO ESSENCIAL DE Myrcia rostrata DC. (MYRTACEAE)

Cited by 9 publications

References 0 publications

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

Potencial Genotóxico do Extrato Metanólico de Psidium guineense Sw (Araçá verdadeiro) em Células da Mucosa Oral

Inhibition of α-glucosidase, pancreatic lipase, and antioxidant property of Myrcia hatschbachiiD. Legrand containing gallic and ellagic acids

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