No abstract

The aim of the present study was to evaluate, in vitro, the photoprotective activity of the ethanolic extract of Rhaphiodon (R.) echinus. The experiment was carried out with different concentrations of the natural product (50, 100, 500 and 1000 μg / mL). Through scans with the aid of an spectrophotometer, in the ranges (290 to 320 nm) with 5 nm intervals. The data were submitted to Mansur et al. (1986) equation. According to the results obtained, only the two highest concentrations (500 μg / mL and 1000 μg / mL) showed considerable photoprotection values and above the minimum protection factor of 6 (SPF), being 23.65 and 25.00 respectively. Thus, the photoprotective activity of the ethanol extract, in vitro, of R. echinusdemonstra uma importante característica bioativa. Além disso, o resultado ainda sugere um possível uso dessa planta em formulações fitocosméticas, uma vez que o uso de plantas como fotoprotetores é uma das alternativas acessíveis.

The SARS-CoV-2 infection started in Wuhan / China in December 2019, spreading rapidly across Europe, the United States and Latin America, becoming a pandemic. COVID-19 is an acute disease with symptoms similar to those of a cold and can evolve to symptoms similar to severe pneumonia, its transmission happens through close contact, through droplets of saliva or particles that contain the virus. The present work aims to carry out an integrative literature review containing the main information about the impact of COVID-19 on the health of newborns and pregnant women. In order to develop it, a narrative review of the scientific literature was carried out, through an electronic search in the MEDLINE, SciELO, PubMed and LILACS databases. The WHO has advocated social isolation, however prenatal care should not be suspended during the pandemic period, noting the importance of taking care of yourself and the baby during pregnancy. Preventive measures, especially hygiene, must be adopted during all baby care. Some studies suggest that SARS-CoV-2 transmission from mother to child during pregnancy is unlikely, but that after birth, a newborn can become infected when exposed to an infected person. In addition, there have been some reported adversities, such as premature birth in babies born to mothers who tested positive for SARS-CoV-2. It can be concluded that more studies are needed to elucidate the characteristics of Sars-Cov-2 infection, especially in newborns, while the ideal is to maintain confidence in science and follow the recommendations recommended by WHO.

The present work aims to evaluate the Minimum Inhibitory Concentration of Adherence (MICA) of the essential oils of Eucalyptus globulus and Eucalyptus citriodora against the bacterium Klebsiella pneumoniae. It was performed the determination of the Minimum Inhibitory Concentration of Adherence (MICA) using the inclined tube technique, in the presence of 5% sucrose. After 24 hours, the reading was performed through visual observation of the bacterium's adherence to the tube walls. It was observed that the essential oil of Eucalyptus globulus showed a good antiadherent efficiency to the strain of Klebsiella pneumoniae, showing biofilm inhibition at a concentration of 1:8 similar to the 0.12% chlorhexidine digluconate control. Eucalyptus citriodora oil did not inhibit biofilm formation in any of the tested concentrations. It was concluded that only the essential oil belonging to the Eucalyptus globulus species, showed antiadherent action against the strain of Klebsiella pneumoniae, which can be used as an alternative method to combat biofilms produced by K. pneumoniae.

Neste artigo, um estudo sintético assistido por irradiação de micro-ondas para produzir 2-indolizina-carbonitrila e 2-indolizina-carboxilato de metila em bons a altos rendimentos (70 e 81%) em uma etapa a partir de adutos de Morita-Baylis-Hillman (AMBH) é apresentado. Estes compostos foram subsequentemente transformados em altos rendimentos (94-100%) em três derivados 2-indolizínicos. Os cinco compostos sintetizados foram idealizados in silico objetivando potenciais atividades seletivas como moduladores de canais iônicos. Estas atividades foram sugeridas pelos valores de pontuação usando o programa quimioinformático Molinspiration. In this work, a microwave-assisted synthesis study by microwave irradiation to produce indolizine-2-carbonitrile and indolizine-2-carboxylate in good to high yields (70 and 81%, respectively) in one step from Morita-Baylis-Hillman adducts (MBHA) is presented. These compounds were subsequently transformed to high yields (94 to 100%, respectively) in three 2-indolizine derivatives. The five synthesized compounds were designed in silico aiming to present potential selective activities as ion channel modulators. These activities were suggested by the score values using Molinspiration Cheminformatics program.