Vitamin D Deficiency is not Associated with Higher Levels of SYNTAX Score

Abstract

Objective To evaluate the association between serum vitamin D (vitD) level and SYNTAX (synergy between percutaneous coronary intervention with taxus and cardiac surgery) score (SS). Methods The medical records of consecutive patients, who underwent coronary artery bypass graft surgery, were retrospectively reviewed. The study group consisted of 158 patients. Biochemical, clinical, and echocardiographic parameters and SS were evaluated in all patients. The patients were divided into 2 groups according to SS (≥23= high, <23= low). Results The high SYNTAX score (HSS) group was older and had higher body mass index, C-reactive protein (CRP), low-density lipoprotein, and fasting plasma glucose level than the low SYNTAX score (LSS) group. The HSS group had lower high-density lipoprotein and vitD level than the LSS group. The HSS group had a higher prevalence of diabetes mellitus (DM), hypertension (HT), hyperlipidemia (HL), and current smoking patients than the LSS group. On univariate analysis, age, HT, DM, HL, smoking, CRP, and serum vitD level were associated with HSS. On multivariate analysis, HT, DM, and HL were independent predictors of HSS (odds ratio [OR]: 2.137, 95% confidence interval [CI]: 1.468-2.935, P <0.001; OR: 3.559, 95% CI: 2.763-5.927, P <0.001; OR: 2.631, 95% CI: 1.529-3.438, P <0.001; respectively). Conclusion In our study, we have found out that HT, DM, and HL were independent predictors of HSS. Serum vitD level was not found to be an independent predictor of HSS.

Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review

“…Eight studies ( 1 , 21 – 24 , 26 – 28 ) in our meta-analysis reported postoperative severe events and VitD level. Severe events included postoperative atrial fibrillation (Po-AF) and high SYNTAX score.…”

“…However, 15 articles were excluded by reading the complete articles due to: article type ( n = 1); absence of measurement of VitD levels at required time points or the outcomes described in the criteria of inclusion ( n = 13); not using the standard definition of VitD deficiency ( n = 1). Ultimately, 16 reports ( 1 , 2 , 18 – 31 ) were included in the meta-analysis ( Figure 1 ). No reports from China met the inclusion criteria.…”

“…The characteristics of the involved patients in all included studies are presented in Table 1 . The sixteen published reports ( 1 , 2 , 18 – 31 ) enrolled a total of 1,785 patients (children and adults) from 10 countries. Five studies ( 2 , 18 , 19 , 25 , 31 ) focused on children with congenital heart disease and 11 studies ( 1 , 20 – 24 , 26 – 30 ) were on adults, of which seven studies ( 1 , 22 – 24 , 26 – 28 ) reported patients undergoing coronary artery bypass surgery (CABG).…”

“…The sixteen published reports ( 1 , 2 , 18 – 31 ) enrolled a total of 1,785 patients (children and adults) from 10 countries. Five studies ( 2 , 18 , 19 , 25 , 31 ) focused on children with congenital heart disease and 11 studies ( 1 , 20 – 24 , 26 – 30 ) were on adults, of which seven studies ( 1 , 22 – 24 , 26 – 28 ) reported patients undergoing coronary artery bypass surgery (CABG). Eleven studies ( 1 , 2 , 18 , 19 , 21 , 23 – 26 , 29 , 31 ) reported a detailed method used to measure the serum concentration of VitD and 10 studies ( 1 , 2 , 18 – 20 , 25 , 26 , 28 , 30 , 31 ) reported a clear definition of VitD deficiency as 25-(OH) VitD <20 ng/ml or <50 nmol/L.…”

“…Vitamin D (VitD) has well-established roles in calcium absorption and bone mineralization ( 1 ). Exposure to sunlight and dietary intake are essential to ensure an adequate store of VitD, which functions mainly in the intestine, kidney, and bone ( 2 ).…”