Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran

Akhlaghi, Boshra; Firouzabadi, Negar; Foroughinia, Farzaneh; Nikparvar, Marzieh; Dehghani, Pouyan

doi:10.1186/s12872-023-03155-5

Cited by 4 publications

(4 citation statements)

References 51 publications

(58 reference statements)

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“…The rs731236 polymorphism is associated with increased CAD risk in Pakistani and Croatian populations [ 56 , 57 ]. At the same time, researchers from Spain and South Iran reported no correlation between this polymorphic variant and susceptibility to CAD development [ 58 , 59 ]. Contradictory data have been obtained for the rs1544410 polymorphism— the A allele may have both risky [ 60 ] and protective effects [ 59 ] in relation to CAD development.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, researchers from Spain and South Iran reported no correlation between this polymorphic variant and susceptibility to CAD development [ 58 , 59 ]. Contradictory data have been obtained for the rs1544410 polymorphism— the A allele may have both risky [ 60 ] and protective effects [ 59 ] in relation to CAD development. In the Spanish population, the rs1544410 polymorphism is not associated with the risk of CAD [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to the latest meta-analysis, the polymorphic variants rs2225870, rs1544410 and rs731236 are characterized by risk of CAD development, but the role of the rs7975232 polymorphism is ambiguous [ 62 , 63 ]. The role of genetic polymorphism in the VDR gene in CAD severity has been studied in only one article—the authors reported no associations between the rs1544410 and rs731236 polymorphisms with the severity of this disease [ 59 ]. In our research, we have found no associations of the rs2225870 and rs731236 polymorphisms with CAD severity, but registered significantly lower serum level of 1.25-dihydroxy vitamin D in the high-risk CAD patients with the A/A-A/G genotypes of the rs2225870 polymorphism.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

Ponasenko,

Sinitskaya,

Sinitsky

et al. 2023

Biomedicines

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Coronary artery disease (CAD) remains one of the leading causes of cardiovascular morbidity and mortality worldwide. The maintenance of endothelial homeostasis and vitamin D metabolism play an important role in CAD pathogenesis. This study aimed to determine the association of endothelial homeostasis and vitamin D metabolism gene polymorphism with CAD severity. A total of 224 low-risk patients (SYNTAX score ≤ 31) and 36 high-risk patients (SYNTAX score > 31) were recruited for this study. The serum level of E-, L- and P-selectins; endothelin; eNOS; 25OH; and 1.25-dihydroxy vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA). Polymorphic variants in SELE, SELP, SELPLG, END1, NOS3, VDR and GC were analyzed using a polymerase chain reaction (PCR). We found no differences in the serum levels of the studied markers between high- and low-risk patients. Three polymorphic variants associated with CAD severity were discovered: END1 rs3087459, END1 rs5370 and GC rs2298849 in the log-additive model. Moreover, we discovered a significantly decreased serum level of 1.25-dihydroxy vitamin D in high-risk CAD patients with the A/A–A/G genotypes of the rs2228570 polymorphism of the VDR gene, the A/A genotype of the rs7041 polymorphism of the GC gene and the A/A genotype of the rs2298849 polymorphism of the GC gene.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

Ponasenko,

Sinitskaya,

Sinitsky

et al. 2023

Biomedicines

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“…The intronic SNPs rs1544410 (G>A) and rs7975232 (A>C), also named BsmI and ApaI, respectively, from the associated restriction enzyme, have been significantly related to low HDL cholesterol and low vitamin D. Homozygotes for the mutated A allele of BsmI resulted in an increased risk of CAD [139]. In other populations, BsmI but not TaqI significantly correlates with the incidence of CAD [140]. Other authors found no relationship between ApaI or TaqI and CAD, while a significant association was reported for another SNP, rs2228570, also known as FokI (A>T,C,G on exon 2) [141].…”

Section: Geneticsmentioning

confidence: 99%

Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes

Nardin,

Verdoia,

Nardin

et al. 2024

Biomedicines

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Vitamin D is rightly recognized as an essential key factor in the regulation of calcium and phosphate homeostasis, affecting primary adequate bone mineralization. In the last decades, a more complex and wider role of vitamin D has been postulated and demonstrated. Cardiovascular diseases have been found to be strongly related to vitamin D levels, especially to its deficiency. Pre-clinical studies have suggested a direct role of vitamin D in the regulation of several pathophysiological pathways, such as endothelial dysfunction and platelet aggregation; moreover, observational data have confirmed the relationship with different conditions, including coronary artery disease, heart failure, and hypertension. Despite the significant evidence available so far, most clinical trials have failed to prove any positive impact of vitamin D supplements on cardiovascular outcomes. This discrepancy indicates the need for further information and knowledge about vitamin D metabolism and its effect on the cardiovascular system, in order to identify those patients who would benefit from vitamin D supplementation.

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The relationship between cardiovascular pathology and impaired glucose metabolism with vitamin D deficiency (literature review and own data)

Goncharova

Imanova

2023

Mìžnarodnij endokrinologìčnij žurnal

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Background. Vitamin D plays a significant role in many processes in the human body, which diversifies the symptoms of its insufficiency, so it is not always possible to diagnose its deficiency in a timely manner. At the same time, according to a number of clinical studies, an inverse relationship has been proven between a reduced level of vitamin D and mortality from all causes and cardiovascular diseases, the course of diabetes mellitus (DM), hypertension, chronic kidney disease, atherosclerosis, coronary heart disease; and the mechanisms of the influence of vitamin D deficiency on various metabolic processes have been revealed. The development and progression of cardiovascular diseases and vascular complications of DM are currently the main causes of disability and mortality of patients. All this substantiates the need to control and monitor the vitamin D supply in patients with this comorbid pathology. Aim of the study is to investigate the presence and severity of vitamin D deficiency in patients with type 2 DM and the presence of concomitant cardiac pathology. Materials and methods. Main group included 31 patients (17 men and 14 women aged 51.51 ± 1.73 years, with duration of DM of 8.59 ± 1.70 years) who were treated in the endocrinology clinic from October 2022 to May 2023. The comparison group consisted of 27 patients with type 2 DM who stayed in this clinic in 2020–2021. Serum level of 25-hydroxycholecalciferol (25(OH)D) was studied using the enzyme-linked immunosorbent assay. The level of vitamin D less than 20–30 ng/ml was considered as its insufficiency, and the level below 20 ng/ml as deficiency. Statistical processing was carried out using Microsoft Excel and Statistica 6.0. Results. In the main group, cardiac pathology manifested itself by the presence of hypertension detected in all patients (stage I — 6 cases; stage II — 21 and stage IІI — 4); coronary heart disease and cardiosclerosis — in 7 patients; heart failure of the first or second degree — in all individuals. All patients in the main group were vitamin D deficient or insufficient: 15 had a deficiency (12.96 ± 1.06 ng/ml), and 16 had an insufficiency (23.68 ± 0.72 ng/ml). In contrast to the comparison group, patients from the main group had a significantly lower average level of vitamin D (18.49 ± 1.16 ng/ml vs 28.98 ± 1.02 ng/ml, p < 0.001). Taking into account a decrease in the level of vitamin D supply of patients, including those with comorbid pathology examined in 2022–2023, which is obviously associated with a long stay in shelters and a stressful situation caused by the state of war, and its impact on the course of cardiovascular diseases and diabetes, it is necessary to pay more attention to the detection and timely appropriate correction of vitamin D deficiency. Conclusions. In patients with type 2 diabetes and comorbid cardiovascular pathology, there is a decrease in the level of vitamin D supply. During the war in Ukraine, there is a probable deepening of vitamin D deficiency. The negative impact of vitamin D deficiency on the course of diabetes and cardiovascular pathology justifies the need to monitor vitamin D supply in such patients.

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Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran

Cited by 4 publications

References 51 publications

The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes

The relationship between cardiovascular pathology and impaired glucose metabolism with vitamin D deficiency (literature review and own data)

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