Effect of one time high dose “stoss therapy” of vitamin D on glucose homeostasis in high risk obese adolescents

Brar, Preneet Cheema; Contreras, Mauricio; Fan, Xiaozhou; Visavachaipan, Nipapat

doi:10.20945/2359-3997000000024

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…In the past two decades, numerous observational studies suggested vitamin D deficiency was a risk factor for obesity, T2D, insulin resistance and metabolic syndrome, while hypothesising that re-establishing vitamin D adequacy could lead to the improvement of these conditions. However, there is a lack of conclusive evidence from randomized control clinical trials to support that optimization of 25OHD levels is able to prevent these metabolic disorders (174), has beneficial effects on glucose homeostasis (175) or results in a lower incidence of cardiovascular events (176). Therefore, vitamin D supplementation with the sole purpose of promoting weight loss, decreasing the risk of obesityrelated co-morbidities or improve ongoing metabolic conditions cannot be recommended.…”

Section: Reasoningmentioning

confidence: 99%

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Pasquali

Casanueva

Haluzı́k

et al. 2020

European Journal of Endocrinology

100

127

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Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are currently no data showing that more sophisticated methods are more useful to guide the endocrine work-up in obesity. An increased BMI leads to a number of hormonal changes. Additionally, concomitant hormonal diseases can be present in obesity and have to be properly diagnosed – which in turn might be more difficult due to alterations caused by body fatness itself. The present European Society of Endocrinology Clinical Guideline on the Endocrine Work-up in Obesity acknowledges the increased prevalence of many endocrine conditions in obesity. It is recommended to test all patients with obesity for thyroid function, given the high prevalence of hypothyroidism in obesity. For hypercortisolism, male hypogonadism and female gonadal dysfunction, hormonal testing is only recommended if case of clinical suspicion of an underlying endocrine disorder. The guideline underlines that weight loss in obesity should be emphasized as key to restoration of hormonal imbalances and that treatment and that the effect of treating endocrine disorders on weight loss is only modest.

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Section: Reasoningmentioning

confidence: 99%

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Pasquali

Casanueva

Haluzı́k

et al. 2020

European Journal of Endocrinology

100

127

View full text Add to dashboard Cite

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“…As discussed previously, there is evidence of association between low levels of vitamin D and cardiovascular risk factors in children, which may lead to cardiovascular diseases in adulthood. Therefore, in recent years new randomized controlled studies examining effects of vitamin D supplementation on cardiovascular outcomes in children and adolescents have been performed [74][75][76][77][78][79][80][81][82][83][84].…”

Section: The Impact Of Vitamin D Supplementationmentioning

confidence: 99%

“…In the last five years, six RCTs focused on obese nondiabetic adolescents (11-17 years) [79][80][81][82][83][84]. Shah et al [80] failed both to increase 25OHD levels and to alter markers of inflammation and cardiovascular risk in a group of obese adolescents through a vitamin D supplementation of 150,000 IU every 3 months.…”

Section: The Impact Of Vitamin D Supplementationmentioning

confidence: 99%

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Vitamin D and Cardiovascular Risk: Which Implications in Children?

Savastio

Pozzi

Tagliaferri

et al. 2020

IJMS

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Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

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“…On the other hand, Brar et al [15] used a high dose of VD in obese adolescent and did not find improvement on insulin secretion and sensitivity, and concluded that this supplementation did not appear to produce benefits on the homeostasis of the glucose on obese adolescents. Savastano et al [32] and Gul et al [33] found a negative correlation between VD levels and fasting glycemia.…”

Section: Discussionmentioning

confidence: 98%

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

Haber¹,

Quesada²,

Lopes³

et al. 2018

JDM

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The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are particularly significant in adolescents since it influences several aspects of growth, development, and puberty. During this phase of life, both girls and boys develop reproductive aspects, and secondary sexual characteristics and the adequate nutritional status appear to be the prerequisite for normal pubertal development. Due to the importance of VD in adolescents, the objective of this study was to investigate the association of the levels of this vitamin with glycemic, lipid, and anthropometric profile and sexual maturation stages of adolescents. Anthropometric (weight and height) and biochemical (fasting glycemia, total cholesterol, HDL-c, LDL-c, and triglycerides) data and VD levels were collected in 67 adolescents. 66% of the adolescents showed VD sufficiency, 28% insufficiency, and 6% showed the deficiency. There was a significant difference in VD levels between the stages of sexual maturation for boys and girls. Overweight patients had lower serum VD levels. The correlation analysis indicated a positive correlation between VD and fasting glycemia and HDL-c, but with no significant difference. A negative correlation was observed between VD and cholesterol, LDL-c and triglycerides, but also with no significant difference. Once VD is crucial for bone health, and as it seems it is necessary to the homeostasis of glycemia, lipids, and body weight, we suggest that more studies should be conducted to confirm the precise role of this vitamin in the promotion and maintenance of health in this population. How to cite this paper: Haber, J.

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Effect of one time high dose “stoss therapy” of vitamin D on glucose homeostasis in high risk obese adolescents

Cited by 8 publications

References 34 publications

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

Vitamin D and Cardiovascular Risk: Which Implications in Children?

Association of Vitamin D Levels with the Metabolic Profile and Sexual Maturation Stage of Adolescents

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