Vitamin D and Cardiovascular Risk: Which Implications in Children?

Savastio, Silvia; Pozzi, Erica; Tagliaferri, Francesco; Degrandi, Roberta; Cinquatti, Roberta; Rabbone, Ivana; Bona, Gianni

doi:10.3390/ijms21103536

Cited by 17 publications

(13 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some of the mechanisms by which vitamin D provides cardioprotective action could be due to foam cell growth prevention, which could lead to rapid relaxation of cardiac myocytes after calcium efflux and nitric oxide release [ 42 ]. In support of our results, low vitamin D levels are associated with an increased risk of cardiovascular disease (CVD) and mortality in people with elevated lipid levels [ 43 ]. It was also observed that vitamin D inhibited the intracellular NF- κ B pathway and in vitro renin synthesis and attenuated the progression of coronary artery disease [ 44 – 48 ].…”

Section: Discussionsupporting

confidence: 68%

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Alsamghan

Alsaleem

Alzahrani

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Background. Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. Methodology. A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique. Result. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092–4.05) indicating a higher risk for the development of ASCVD among those patients. Conclusion. Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.

show abstract

Section: Discussionsupporting

confidence: 68%

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Alsamghan

Alsaleem

Alzahrani

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…If the association proves to be causal, optimizing vitamin D status through supplementation in the pediatric population could slow the rising BP prevalence in this population group. In light of the widespread vitamin D deficiency, and the various health benefits of this vitamin on the musculoskeletal [ 137 ], immune [ 138 ], neurological [ 139 ], and cardiovascular [ 140 ] systems, optimizing vitamin D status in the pediatric population remain needed.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies

et al. 2021

View full text Add to dashboard Cite

Background Childhood hypertension is a growing public health problem. Simultaneously, hypovitaminosis D is widespread in this population and could be associated with hypertension. This study systematically reviewed the literature on the relationship between vitamin D status and blood pressure (BP) in children and adolescents. Methods Following the PRISMA guidelines, PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, and ClinicalTrials.gov and the gray literature without language or time restrictions were searched. We included observational studies, assessed their risk of bias, and extracted data on population characteristics, vitamin D status and BP measurements, and the association between the two variables. A narrative analysis of the studies was performed. Results In total, 85 studies were included. Prospective cohort studies showed no association between vitamin D and BP, and generally, they were flawed. Also, the majority of non-prospective cohort studies (cross-sectional, retrospective, case-control) did not report an association between vitamin D and BP. They were mostly flawed regarding BP measurement and adjusting to potential confounders. Conclusion The results on the relationship between vitamin D status and BP in children and adolescents varied between the studies, and mainly pointed towards lack of association.

show abstract

“…In children with obesity and hepatic steatosis, vitamin D levels were significantly lower than in children with obesity without hepatic steatosis [ 85 ]. Some studies have shown an association between vitamin D deficiency and a higher risk of cardiovascular disease and mortality, which indicates the need for its supplementation [ 86 ].…”

Section: Evaluation and Possible Interventions In Obesity-related Cardiovascular Risk Factors In Childrenmentioning

confidence: 99%

Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions

Močnik

Varda

2021

Metabolites

View full text Add to dashboard Cite

The increasing burden of obesity plays an essential role in increased cardiovascular morbidity and mortality. The effects of obesity on the cardiovascular system have also been demonstrated in childhood, where prevention is even more important. Obesity is associated with hormonal changes and vascular dysfunction, which eventually lead to hypertension, hyperinsulinemia, chronic kidney disease, dyslipidemia and cardiac dysfunction—all associated with increased cardiovascular risk, leading to potential cardiovascular events in early adulthood. Several preventive strategies are being implemented to reduce the cardiovascular burden in children. This paper presents a comprehensive review of obesity-associated cardiovascular morbidity with the preventive diagnostic workup at our hospital and possible interventions in children.

show abstract

Vitamin D and Cardiovascular Risk: Which Implications in Children?

Cited by 17 publications

References 83 publications

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies

Cardiovascular Risk Factors in Children with Obesity, Preventive Diagnostics and Possible Interventions

Contact Info

Product

Resources

About