A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy

Karimi, Maryam; Karimian, Khashayar; Heli, H.

doi:10.1590/s2175-97902020000118973

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…Besides, the high stability to this system could be attributed to the nanometric size of the droplets generated. 96 , 97 As expected, the spherical morphology visualized by TEM confirmed nanodroplets in a uniform distribution as previously presented by DLS results. Considering the character of a self-nanoemulsifying drug delivery system, particle size and its homogeneity is very critical, once it will impact factors such as drug release profile, cellular uptake and biodistribution.…”

Section: Discussionsupporting

confidence: 87%

Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm

Pereira,

Melo,

de Campos

et al. 2024

IJN

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Section: Discussionsupporting

confidence: 87%

Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm

Pereira,

Melo,

de Campos

et al. 2024

IJN

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“…Measuring the viscosity of nanoemulsion with a digital viscometer (Brookfield viscometer) verifies the kind of emulsion. Larger viscosity indicates that the emulsion is w/o, whereas lower viscosity indicates that the emulsion is o/w [32].…”

Section: Viscosity Measurementmentioning

confidence: 99%

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Rodriques¹,

Prajapati²

2022

Pharmacophore

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The purpose of this research was to develop and evaluate the Nanoemulsion of Dolutegravir sodium. Nanoemulsion was made by the high-shear homogenization method. Materials and method: Oleic acid was used as the oil phase, Tween 80, and Acconon MC8-2 EP/NF (Smix; 1:1) were utilized as surfactant and co-surfactant respectively while distilled water was employed as an aqueous phase. The formulations were evaluated based on globule size, zeta potential, pH, viscosity, percentage transmittance, centrifugation, dye test, dilutability test, and Fourier transform spectroscopy. Furthermore, in vitro drug release studies and stability studies were also conducted. NE1 has shown the least particle size of 96.71 nm, viscosity of 86.4 cp, and maximum drug release of 97.55 % CDR in 45 hrs compared with pure drug (32.98% CDR in 45 hrs). The stability study confirmed no changes in formulations at 1 month at 40 0 ± 2 0 C and 75% ± 5%. The findings suggest that nanoemulsions might be an effective vehicle for the oral administration of Dolutegravir sodium for the treatment of HIV.

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“…Targeted, photothermal, photodynamic, sonodynamic, radiation-chemo, and stem cell therapy are among the new routes of cancer treatment. Nanomedicine has introduced novel treatment approaches and represented solutions for challenges in cancer medicine [2][3][4][5][6][7][8][9].…”

mentioning

confidence: 99%

“…In chemotherapy, most of the traditional drugs have had problems such as toxicity, poor aqueous solubility, and low permeability that limit their therapeutic efficiency. Nanotechnological-based drug delivery systems can resolve the main problem issues of the current drugs through introducing different types of nanosystems as drug delivery vehicles [3,[9][10][11][12]. In this regard, nano-niosomes, as self-assemble delivering systems for either hydrophilic or hydrophobic agents, are successful in pharmacology and pharmaceutics studies due to biodegradability, biocompatibility, bioavailability, low cost, stability, and diversity of suitable surfactants for their fabrication [13].…”

mentioning

confidence: 99%

Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines

2024

J Biomed Phys Eng

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Background: Docetaxel (DXL) is an antineoplastic agent for cancer treatment, the therapeutic efficiency of which is limited due to low solubility, hydrophobicity, and tissue specificity. Objective: In this study, nano-niosomes were introduced for improving therapeutic index of DXL. Material and Methods: In this experimental study, two nano-niosomes were synthesized using Span 20® and Span 80® and a thin film hydration method with DXL loading (DXL-Span20 and DXL-Span80). Characterization, in-vitro cytotoxicity and bioavailability of the nano-niosomes was also evaluated via in-vivo experiments. Results: DXL-Span20 and DXL-Span80 have vesicles size in a range of 84-90 nm and negative zeta potentials. DXL entrapment efficiencies were obtained as 69.6 and 74.0% for DXL-Span20 and DXL-Span80, respectively; with an in-vitro sustained release patterns. Cytotoxicity assays were performed against MDA-MB-231, Calu-6, and AsPC-1 cell lines, and the results indicated that DXL loading into nano-niosomes led to decrement in values of half-maximal inhibitory concentration (IC50) at least 2.5 times and at most 6.5 times, compared to free DXL. Moreover, the rat blood bioavailability of DXL after intraperitoneal administration and the pharmacokinetic parameters indicated higher DXL plasma level and the higher effectiveness of DXL-Span80 compared to DXL-Span20. Conclusion: Carrying DXL by the nano-niosomes led to enhanced cytotoxicity (and lower IC50 values) and higher efficacy with enhanced pharmacokinetic parameters.

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A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy

Cited by 12 publications

References 27 publications

Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm

Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Lipophilic Extract of Viscum album subsp. austriacum (Wiesb.) Vollm

Formulation and Evaluation of Dolutegravir Sodium Nanoemulsion for the Treatment of HIV

Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines

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