Preparation and characterization of naftifine-loaded poly(vinyl alcohol)/sodium alginate electrospun nanofibers

Esentürk, İmren; Balkan, Timuçin; Güngör, Sevgi; Saraç, Sezai; Erdal, Meryem Sedef

doi:10.1590/s2175-97902019000318440

Cited by 2 publications

(2 citation statements)

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“…The fiber layers produced from the PVA/gelatin and PVA/alginate blends were investigated so as to determine the time required to crosslink the gelling component, i.e., the gelatin and the alginate, which resulted in the selection of 4 h of crosslinking. As found in this and other studies [37,38], a longer time in glutaraldehyde vapor leads to crosslinking of PVA. In our study, a longer crosslinking time led to the growth of the PVA and the formation of a polymer film.…”

Section: Discussionsupporting

confidence: 87%

“…It is clear from Figure 2 that the longer fiber layer crosslinking time led to the formation of films in both cases. Thus, in order to preserve the fibrous structures of the materials, they were both crosslinked for 4 h. This is in contrast to previous publications [37,38], where alginate was crosslinked for 24 h. In the case of nanofibers, therefore, a shorter crosslinking time is sufficient. It is clear from Figure 2 that the longer fiber layer crosslinking time led to the formation of films in both cases.…”

Section: Fiber Layer Crosslinkingmentioning

confidence: 98%

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Preparation of a Hydrogel Nanofiber Wound Dressing

et al. 2021

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The study addressed the production of a hydrogel nanofiber skin cover and included the fabrication of hydrogel nanofibers from a blend of polyvinyl alcohol and alginate. The resulting fibrous layer was then crosslinked with glutaraldehyde, and, after 4 h of crosslinking, although the gelling component, i.e., the alginate, crosslinked, the polyvinyl alcohol failed to do so. The experiment included the comparison of the strength and ductility of the layers before and after crosslinking. It was determined that the fibrous layer following crosslinking evinced enhanced mechanical properties, which acted to facilitate the handling of the material during its application. The subsequent testing procedure proved that the fibrous layer was not cytotoxic. The study further led to the production of a modified hydrogel nanofiber layer that combined polyvinyl alcohol with alginate and albumin. The investigation of the fibrous layers produced determined that following contact with water the polyvinyl alcohol dissolved leading to the release of the albumin accompanied by the swelling of the alginate and the formation of a hydrogel.

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Section: Discussionsupporting

confidence: 87%

Section: Fiber Layer Crosslinkingmentioning

confidence: 98%