Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated. Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers.
Conclusion:Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.
Nanofibers are frequently encountered in daily life as a modern material with a wide range of applications. The important advantages of production techniques, such as being easy, cost effective, and industrially applicable are important factors in the preference for nanofibers. Nanofibers, which have a broad scope of use in the field of health, are preferred both in drug delivery systems and tissue engineering. Due to the biocompatible materials used in their construction, they are also frequently preferred in ocular applications. The fact that they have a long drug release time as a drug delivery system and have been used in corneal tissue studies, which have been successfully developed in tissue engineering, stand out as important advantages of nanofibers. This review examines nanofibers, their production techniques and general information, nanofiber-based ocular drug delivery systems, and tissue engineering concepts in detail.
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