The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions

Özevren, Hüseyin; Deveci, Engin; Tuncer, Mehmet Cudi

doi:10.1590/s0102-865020200040000006

Cited by 3 publications

(6 citation statements)

References 39 publications

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“…It is necessary to emphasize that the approach of bone defects for study of bone healing may be heterogeneous 15 . However, the trauma in order to obtain surgical bed or on craniotomy approach may provide injuries, such as traumatic brain injury, as well as disruption of the blood-brain barrier integrity and the neurovascular unit, culminating in vascular leakage, edema, hemorrhage, hypoxia and neuronal death 16 . According to this premise, Özevren et al 16,17 demonstrated traumatic brain injury when cortical is injured or removed.…”

Section: Discussionmentioning

confidence: 99%

“…However, the trauma in order to obtain surgical bed or on craniotomy approach may provide injuries, such as traumatic brain injury, as well as disruption of the blood-brain barrier integrity and the neurovascular unit, culminating in vascular leakage, edema, hemorrhage, hypoxia and neuronal death 16 . According to this premise, Özevren et al 16,17 demonstrated traumatic brain injury when cortical is injured or removed. The authors described a variety of pathological factors, such as oxidative stress, the inflammatory response, and apoptosis, as well as enlarged Micrographs A, B, C, D and E demonstrate the pattern of distribution of immunoexpression of OC (brownish color) in the ABG, ABG + PC, ABG + PPP, PPP and control groups, respectively, two weeks after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…According to this premise, Özevren et al . 16 , 17 demonstrated traumatic brain injury when cortical is injured or removed. The authors described a variety of pathological factors, such as oxidative stress, the inflammatory response, and apoptosis, as well as enlarged blood vessels, bleeding and swelling after traumatic injury in the brain and choroid plexus.…”

Section: Discussionmentioning

confidence: 99%

“…Although many studies have demonstrated a positive effect of PC on osteoneogenesis, others studies revealed deleterious results 19 . The lack of unanimous results about the effect of PC on bone regeneration is attributed to variations in the PC preparations that could alter the platelet quality and/or quantity, which would result in differences in the regenerative potential of PC [14][15][16][17][18][19][20][21][22] . The PC production method used in this study has proven to be able to concentrate large amounts of platelets (upward of 6× concentration), differing from many authors who proposed the hypothesis that intermediate concentrations of platelets could optimize the repair, with maximum stimulation effects generated with approximate concentrations of 2.5×, unlike what would occur with higher concentrations 9,23 .…”

Section: Figure 4 -mentioning

confidence: 99%

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Platelet-concentrated and platelet poor-plasma promote different pattern on immunohistochemical expression of TGF-β1, however they impairs the osteoneogensis in calvarial defects treated with autograft due suppression of osteocalcin

et al. 2021

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Herein we evaluated the effects of platelet concentrate (PC) and platelet-poor plasma (PPP) on bone repair using noncritical defects in the calvaria of rabbits and compared them to the presence of TGF-β1 and osteocalcin on reparative sites. Methods: Five noncritical defects of 8.7 mm in diameter were created on the calvaria of 15 animals. Each defect was treated differently, using autograft (ABG), ABG associated with PC (ABG + PC), ABG with PPP (ABG + PPP), isolated PPP, and blood clot (control). The animals were submitted to euthanasia on the second, fourth and sixth week post-surgery. Results: The defects that received ABG+PC or PPP demonstrated lower bone formation when compared to specimens that received ABG in the same period. These results coincided to significant higher immunopositivity for TGF-β1 for specimens that received PC, and lower presence of cytokine in the group PPP. However, either higher or lower presence of TGF-β1 were also correlated to lower presence of osteocalcin. Likewise, these results were similar to findings in specimens treated only with PPP when compared to control. Conclusion: PC and PPP were not effective when applied in association with ABG. Similarly, isolated use of PPP was not beneficial in optimizing the bone repair.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figure 4 -mentioning

confidence: 99%

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Platelet-concentrated and platelet poor-plasma promote different pattern on immunohistochemical expression of TGF-β1, however they impairs the osteoneogensis in calvarial defects treated with autograft due suppression of osteocalcin

et al. 2021

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“…Pure RA-containing products are also available commercially. The diverse biological functions of phenolic compounds like RA can provide various health benefits (Özevren et al 2020 ). RA acts as a powerful anti-oxidant agent mitigating oxidative damage, which could reduce the induction of ROS production via the enhancement of anti-oxidant defense enzymes (Khamse et al 2020 ).…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid

et al. 2022

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Rosmarinic acid (RA) is a natural antioxidant with neuroprotective properties; however, its preventive and therapeutic use is limited due to its slight solubility and poor permeability. This study aimed to improve RA physicochemical properties by systems formation with cyclodextrins (CDs): hydroxypropyl-α-CD (HP-α-CD), HP-β-CD, and HP-γ-CD, which were prepared by the solvent evaporation (s.e.) method. The interactions between components were determined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Fourier Transform infrared spectroscopy (FTIR). The sites of interaction between RA and CDs were suggested as a result of in silico studies focused on assessing the interaction between molecules. The impact of amorphous systems formation on water solubility, dissolution rate, gastrointestinal (GIT) permeability, and biological activity was studied. RA solubility was increased from 5.869 mg/mL to 113.027 mg/mL, 179.840 mg/mL, and 194.354 mg/mL by systems formation with HP-α-CD, HP-β-CD, and HP-γ-CD, respectively. During apparent solubility studies, the systems provided an acceleration of RA dissolution. Poor RA GIT permeability at pH 4.5 and 5.8, determined by parallel artificial membrane permeability assay (PAMPA system), was increased; RA–HP-γ-CD s.e. indicated the greatest improvement (at pH 4.5 from Papp 6.901 × 10−7 cm/s to 1.085 × 10−6 cm/s and at pH 5.8 from 5.019 × 10−7 cm/s to 9.680 × 10−7 cm/s). Antioxidant activity, which was determined by DPPH, ABTS, CUPRAC, and FRAP methods, was ameliorated by systems; the greatest results were obtained for RA–HP-γ-CD s.e. The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was increased from 36.876% for AChE and 13.68% for BChE to a maximum inhibition of the enzyme (plateau), and enabled reaching IC50 values for both enzymes by all systems. CDs are efficient excipients for improving RA physicochemical and biological properties. HP-γ-CD was the greatest one with potential for future food or dietary supplement applications.

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The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions

Cited by 3 publications

References 39 publications

Platelet-concentrated and platelet poor-plasma promote different pattern on immunohistochemical expression of TGF-β1, however they impairs the osteoneogensis in calvarial defects treated with autograft due suppression of osteocalcin

Platelet-concentrated and platelet poor-plasma promote different pattern on immunohistochemical expression of TGF-β1, however they impairs the osteoneogensis in calvarial defects treated with autograft due suppression of osteocalcin

Biomedical features and therapeutic potential of rosmarinic acid

Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid

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