Influence of oophorectomy on glycemia and lipidogram

Teixeira, Renan Kleber Costa; Feijó, Daniel Haber; Valente, Antônia Regiane Pereira Duarte; Carvalho, Luan Teles Ferreira de; Granhen, Hícaro Donato; Petroianu, Andy; Botelho, Nara Macedo

doi:10.1590/s0102-865020180050000003

Cited by 4 publications

(3 citation statements)

References 15 publications

(17 reference statements)

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“…n for each group is in the column skeletal muscle of male mice predominate the estrogen receptor beta, that reduces the expression of the GLUT4 (Barros et al, 2006(Barros et al, , 2009. Different studies in female rats submitted to ovariectomy found that they have insulin resistance and glucose intolerance (Faulds et al, 2012;Kleber Costa Teixeira et al, 2018;Saengsirisuwan et al, 2009). Here, we show for the first time that glucose curve during GTT in 18-month-old female rats is similar to younger counterparts (Figure 2b,c).…”

Section: Discussionsupporting

confidence: 58%

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

et al. 2020

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Aging affects the body composition and balance of energy metabolism. Here, we collected in a single work several physiological parameters to show how aging and sex differences can influence energy homeostasis. Body mass index (BMI), Lee index, glucose tolerance, glycemia, and lipidogram in fasting were measured in male and female Wistar rats at the ages of 2, 6, 9, 12, and 18 months. We also measured the lipid profile, free fatty acids, glycerol, glycemia, leptin, adiponectin, insulin, corticosterone (CORT), prolactin (PRL), thyroid stimulated hormone, and triiodothyronine (T3) in 3‐ and 18‐month‐old rats of both sexes, fed ad libitum. Animals were classified as obese beginning at 2 months in males and 6 months in females. Aged male rats showed hyperglycemia and glucose intolerance compared to young males and old females. In the ad libitum condition, the 18‐month males presented higher serum levels of triglycerides, total cholesterol, and free fatty acids than females. The 18‐month‐old females had higher PRL and CORT concentration than males, but insulin and T3 were higher in 18‐month‐old males than females. Our work demonstrated that aging processes on energy metabolism in rats is sex specific, with a better lipid profile and glucose tolerance in aged females.

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Section: Discussionsupporting

confidence: 58%

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

et al. 2020

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“…The ovariectomy itself resulted in an increase in triglyceride levels. The higher triglyceride levels could be associated with the lack of sex hormones such as in menopause 19 . After treating OVX animals with pilocarpine, there was a significant decrease in triglycerides in the 30 min (90.40 ± 21.58 mg/dL) and 90 min (54.60 ± 16.30 mg/dL) of SE onset, compared to CTR-OVX (214.50 ± 43.00 mg/dL) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Sanabria

Bittencourt

Perosa

et al. 2020

Sci Rep

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The Amazon rodent Proechimys guyannensis is widely studied for hosting various pathogens, though rarely getting sick. Previous studies on male Proechimys have revealed an endogenous resistance to epilepsy. Here, we assess in female Proechimys, whether sex hormones and biochemical aspects can interfere with the induction of status epilepticus (SE). The lithium-pilocarpine ramp-up protocol was used to induce SE, and blood sera were collected at 30 and 90 min after SE, alongside brains, for biochemical, western blot and immunohistochemical analyses. Results from non-ovariectomised (NOVX) Proechimys were compared to ovariectomised (OVX) animals. Data from female Wistars were used as a positive control of SE inductions. SE latency was similar in NOVX, OVX, and female Wistars groups. However, the pilocarpine dose required to induce SE in Proechimys was higher (25- to 50-folds more). Despite a higher dose, Proechimys did not show strong SE like Wistars; they only reached stage 2 of the Racine scale. These data suggest that female Proechimys are resistant to SE induction. Glucose and progesterone levels increased at 30 min and returned to normal at 90 min after SE. A relevant fact because in humans and rodents, SE leads to hypoglycaemia after 30 min of SE and does not return to normal levels in a short time, a typical adverse effect of SE. In OVX animals, a decrease in GABAergic receptors within 90 min of SE may suggest that ovariectomy produces changes in the hippocampus, including a certain vulnerability to seizures. We speculate that progesterone and glucose increases form part of the compensatory mechanisms that provide resistance in Proechimys against SE induction.

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“…The level of estrogen also appears to influence the prevalence of MetS. Thus, oophorectomy-induced estrogen depletion in rats induces a worsening of most MetS components (lipids, glucose, HDL, and LDL) [ 272 , 273 ], while in women under 50 years of age, i.e., undergoing menopause, its prevalence increases [ 274 , 275 ]. Furthermore, in women who have suffered hysterectomy (often accompanied by bilateral oophorectomy to prevent subsequent ovarian cancer) an increase in blood glucose level [ 276 ] and hypertension [ 277 ] has been reported.…”

Section: Metabolic Syndromementioning

confidence: 99%

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

et al. 2023

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Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only reflected in differences between men and women, but also between women themselves, depending on the hormonal changes associated with the menopause. The observed sex differences in gut microbiota composition have led to multiple studies highlighting the interaction between steroid hormones and the gut microbiota and its influence on metabolic diseases, ultimately pointing to a new therapy for these diseases based on the manipulation of the gut microbiota. This review aims to shed light on the role of sexual hormones in sex differences in the development and prevalence of metabolic diseases, focusing on obesity, MetS and T2D. We focus also the interaction between sex hormones and the gut microbiota, and in particular the role of microbiota in aspects such as gut barrier integrity, inflammatory status, and the gut–brain axis, given the relevance of these factors in the development of metabolic diseases.

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Influence of oophorectomy on glycemia and lipidogram

Abstract: Oophorectomy was related to dyslipidemia and insulin resistance, mainly after 50th days.

Cited by 4 publications

References 15 publications

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

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