Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

Khorshidi, Hamid Reza; Kasraianfard, Amir; Derakhshanfar, A; Rahimi, Siavash; Sharifi, Ali; Makarchian, Hamid Reza; Ghorbanpoor, Manoochehr; Javadi, Seyed Mohammad Reza

doi:10.1590/s0102-865020170080000004

Cited by 10 publications

(5 citation statements)

References 28 publications

(23 reference statements)

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“…We successfully designed a study to determine whether the material can be used for this purpose. There have been experimental works focusing on utilization of different locoregional types of protection in the site of intestinal anastomosis [9][10][11][12][13][14][15][16] , yet no use of nanofibrous scaffolds has been described so far.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been modified and improved repeatedly throughout the history of modern surgery, the mentioned anastomotic leakage as well as other kinds of complications have not been eradicated completely so far (though their frequency has been lowered noticeably). Various sealing techniques and materials were tested both experimentally and clinically including fibrin patches, fibrin glue, collagen patches, hyaluronic acid derivatives and many others [9][10][11][12][13][14][15][16] as a local barrier protection, while other experiments included systemic administration of various substances 17,18 . The anastomotic leakage occurs in different severity, prolonging the patientsʹ stay in the hospital.…”

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confidence: 99%

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Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model

Rosendorf

Horakova

Klíčová

et al. 2020

Sci Rep

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Anastomotic leakage is a severe complication in gastrointestinal surgery. It is often a reason for reoperation together with intestinal passage blockage due to formation of peritoneal adhesions. Different materials as local prevention of these complications have been studied, none of which are nowadays routinely used in clinical practice. Nanofabrics created proved to promote healing with their structure similar to extracellular matrix. We decided to study their impact on anastomotic healing and formation of peritoneal adhesions. We performed an experiment on 24 piglets. We constructed 3 hand sutured end-to-end anastomoses on the small intestine of each pig. We covered the anastomoses with a sheet of polycaprolactone nanomaterial in the first experimental group, with a sheet of copolymer of polylactic acid with polycaprolactone in the second one and no fortifying material was used in the Control group. The animals were sacrificed after 3 weeks of observation. Clinical, biochemical and macroscopic signs of anastomotic leakage or intestinal obstruction were monitored, the quality of the scar tissue was assessed histologically, and a newly developed scoring system was employed to evaluate the presence of adhesions. The material is easy to manipulate with. There was no mortality or major morbidity in our groups. No statistical difference was found inbetween the groups in the matter of level of peritoneal adhesions or the quality of the anastomoses. We created a new adhesion scoring system. The material appears to be safe however needs to be studied further to prove itsʹ positive effects.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model

Rosendorf

Horakova

Klíčová

et al. 2020

Sci Rep

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“…The colour of the scar was compared to the surrounding skin and subdivided into those of the same colour, those hyperpigmented, and those that were hypopigmented. Grading of adhesions was done intraoperatively, using the modified Nair'/s classification, [14] thus classified into the categories of no adhesion, filmy, moderate, or cohesive adhesions.…”

Section: Methodsmentioning

confidence: 99%

Skin markers and the prediction of intraabdominal adhesion during second Cesarean delivery

2019

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Objectives: The aim of the present study has been to examine skin scar characteristics and striae gravidarum, considering the reliability of each for predicting adhesions in repeat Caesarean sections. Material and methods: A cross-sectional study was done over a period of two years. One hundred pregnant women were invited to participate in the study. Preoperatively, abdominal scar features (according to the scar's appearance) and stria gravidarum were both recorded. Then, at the time of surgery, intraabdominal adhesions were graded according to the modified Nair's classification. Results: Among the skin markers, abdominal scar width (p = 0.001), depressed scar (p = 0.002) and striae colour grading (p = 0.0183) were found to have significant associations with intraabdominal adhesions; yet all were of low validity. Conclusions: Despite growing interest in the use of skin markers in the prediction of intraabdominal adhesions at the time of repeat CS, the present study demonstrates that these markers may not be reliable.

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“…For example, the studies by Khorshidi et al . 24 and Horii et al . 25 showed that sodium hyaluronan and thermally cross-linked gelatine film have significant effects in preventing adhesion formation.…”

Section: Discussionmentioning

confidence: 91%

A rabbit model for assessing symblepharon after alkali burn of the superior conjunctival sac

Kang

Liu³

et al. 2019

Sci Rep

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Symblepharon due to chemical burns affects ocular surface health, and there are currently no satisfactory treatments. To improve our understanding of symblepharon, an appropriate animal model is urgently needed. We established a rabbit model of superior conjunctival sac alkaline burn to evaluate symblepharon severity. Alkali burns were induced in rabbits by contacting the superior conjunctival sac with 2 N NaOH-soaked semicircle filter paper (10 mm diameter) for 60 s, 90 s or 120 s. Clinical and histological features were examined, symblepharon severity was evaluated via conjunctival sac depth (grade I - IV) and volume measurements (grade a-d) post-injury at 4 weeks. With increasing alkali burn duration, corneal perforation and symblepharon severity increased. The 60 s group manifested a sub-conjunctiva scar. The 90 s group featured localized adhesion. The 120 s group was characterized by extensive scar hyperplasia and adhesion. The rabbit model exhibited stable and reliable symblepharon following an alkali burn of the superior conjunctival sac. For further research, 90 s is a suitable duration for conjunctival sac burn. The volume measured using conjunctival sac casting was considered when developing a successful evaluation system for symblepharon severity.

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Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

Cited by 10 publications

References 28 publications

Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model

Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model

Skin markers and the prediction of intraabdominal adhesion during second Cesarean delivery

A rabbit model for assessing symblepharon after alkali burn of the superior conjunctival sac

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