The COVID-19 Pandemic - A Global Public Health Crisis: A Brief Overview Regarding Pharmacological Interventions

Haque, Mainul

doi:10.1590/pboci.2020.137

Cited by 11 publications

(8 citation statements)

References 83 publications

(92 reference statements)

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“…Coronavirus disease 2019 (COVID-19) has instigated a public health and economic calamity worldwide [1]. It continues to in ict substantial morbidity and mortality despite intervention efforts.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Acceptance of Coronavirus Disease-2019 (COVID-19) Vaccine Among Lebanese Health Care Workers Using Health Belief Model

Abou-Abbas¹,

Berry²,

Youssef

et al. 2021

Preprint

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Background: Since Health care workers (HCWs) are at high occupational risk for COVID-19, they are prioritized for immunization. This study aims to assess the acceptance rate of COVID-19 vaccine among HCWs and to identify its determinants.Methodology: A web-based cross-sectional study was conducted over the period extending from 10 to 31 December 2020 among Lebanese HCWs. The Health Belief Model (HBM) was used as theoretical framework. Descriptive statistics were reported using frequency with percentages for categorical variables. Bivariate and multivariable logistic regression were carried out to identify the factors associated with the acceptance of COVID-19 vaccine. Adjusted odds ratio and their 95% confidence intervals were reported. The level of statistical significance was set at a p-value < 0.05. Results: A total of 1800 HCWs have completed the survey. Around half of them were frontliners aged between (30-49) years old. About two third (67.33%) have received their influenza vaccine this year. The acceptance rate of COVID-19 vaccine among surveyed HCWs was 58%. Being a male (aOR=1.988, 95% CI (1.411-2.801)), working in the frontline (aOR=1.610, 95% CI (1.173-2.209), and having received influenza vaccination this year (aOR=1.378, 95% CI(0.990-1.916))were significantly associated with higher COVID-19 vaccine acceptance. However, living in rural area (aOR=0.606, 95%CI (0.440-0.836)), personal history of COVID-19 (aOR=0.695, 95%CI (0.470-1.029), novelty of vaccine (aOR=0.424, 95% CI (0.255-0.706)), side effects (aOR=0.413, 95%CI (0.234-0.731), reliability of manufacturer (aOR=0.434, 95% CI (0.297-0.633) and vaccine frequency (aOR=0.580, 95% CI (0.403-0.836) were negatively associated with the willingness to take it. Remarkably, limited availability (aOR=2.161, 95% CI(1.461-3.197) and accessibility (aOR=1.680, 95% CI (1.141-2.474) to the vaccine were also positively associated to its uptake. Similarly, HCWs who perceived vaccine benefits were more likely to get vaccinated (aOR=11.048, 95% CI (7.993-15.269)). With regards to cues of action, having reliable and adequate information regarding the vaccine (aOR=1.979, 95% CI (1.361-2.878)), recommendation by health authorities (aOR=1.976, 95% CI(1.343-2.908)) or health facilities (aOR=2.684, 95% CI(1.804-3.994)) were positively linked to vaccine acceptance, whilst recommendation by family members (aOR=0.479, 95% CI(0.283-0.811)) was negatively related to it. Conclusion:Pointing out the factors driving moderate vaccine acceptance among HCWs via targeting messages addressing key concerns would be required to reach higher vaccination rate.

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Section: Introductionmentioning

confidence: 99%

Determinants of Acceptance of Coronavirus Disease-2019 (COVID-19) Vaccine Among Lebanese Health Care Workers Using Health Belief Model

Abou-Abbas¹,

Berry²,

Youssef

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…195,196 Hyperimmune globulin is currently used for post-exposure prophylaxis in the treatment of several viral infections, including hepatitis B (HBV), rabies, tetanus toxin, varicella-zoster, rubella, measles, etc. 30,[197][198][199] The COVID-19 pandemic attracted much new research to develop therapeutic drug options, [200][201][202][203] including CPT 80,88,93,102,113,204 to treat patients as no specific medication is available. Initially, the US FDA approved and served EUA, 80,205 regarding CPT but later amended the earlier policy (September-2-2020).…”

Section: Discussionmentioning

confidence: 99%

“…[220][221][222] Moreover, no specific anti-COVID-19 therapy is presently available for its management. 115,162,203,223,224 Therefore, COVID-19 remains a significant threat to mankind. Given the gravity of the situation, CPT appears as an evolving defensive treatment option for near-fatal cases of COVID-19.…”

Section: Recommendationsmentioning

confidence: 99%

<p>Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic</p>

Samad¹,

Sodunke²,

Banna³

et al. 2020

RMHP

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The world is striving against the severe crisis of the COVID-19 pandemic. Healthcare professionals are struggling to treat their patients based on nonspecific therapies. Amidst this uncertainty, convalescent plasma therapy (CPT) has appeared to be an interim adjuvant therapy for severely ill patients of COVID-19 until long-term clinical trial treatment options are available. Considering the transfusion-related hazards, especially lung injuries and microbial transmission, where sensitivity is not ensured, rigorous trials should be conducted to determine this therapy's efficacy. Moreover, the ratio of recovered cases to plasma donors is not satisfying, which questioning this therapy's availability and accessibility. Although some countries are making the treatment free, the attributable cost mandates a justification for its suitability and sustainability. Our article aimed to review the published facts and findings of CPT's effectiveness in lowering the mortality rate of COVID-19. This pandemic showed that healthcare systems worldwide need core reform. A unified global collaboration must align and coordinate to face the current pandemic and enhance world readiness for future outbreaks based on health equity and equality.

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“…22 Over recent years, the socioeconomic, environmental, and ecological impact of infectious diseases has increasingly affected the huge mobile global population, which is encountering both new infections (such as COVID- 19) and battling the worldwide epidemic of multidrug-resistant existing infectious diseases. [23][24][25][26][27][28][29][30][31][32][33] Currently, almost all pathogenic microorganisms have developed some antimicrobial resistance, and few new antimicrobials are being developed and brought to market.…”

Section: Introductionmentioning

confidence: 99%

<p>Strategies to Prevent Healthcare-Associated Infections: A Narrative Overview</p>

Haque¹,

McKimm²,

Sartelli³

et al. 2020

RMHP

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Healthcare-associated infections (HCAIs) are a major source of morbidity and mortality and are the second most prevalent cause of death. Furthermore, it has been reported that for every one-hundred patients admitted to hospital, seven patients in high-income economies and ten in emerging and low-income economies acquire at least one type of HCAI. Currently, almost all pathogenic microorganisms have developed antimicrobial resistance, and few new antimicrobials are being developed and brought to market. The literature search for this narrative review was performed by searching bibliographic databases (including Google Scholar and PubMed) using the search terms: "Strategies," "Prevention," and "Healthcare-Associated Infections," followed by snowballing references cited by critical articles. We found that although hand hygiene is a centuries-old concept, it is still the primary strategy used around the world to prevent HCAIs. It forms one of a bundle of approaches used to clean and maintain a safe hospital environment and to stop the transmission of contagious and infectious microorganisms, including multidrug-resistant microbes. Finally, antibiotic stewardship also has a crucial role in reducing the impact of HCAIs through conserving currently available antimicrobials.

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The COVID-19 Pandemic - A Global Public Health Crisis: A Brief Overview Regarding Pharmacological Interventions

Abstract: How to cite this article: Haque M. The COVID-19 pandemic-a global public health crisis: a brief overview regarding pharmacological interventions. Pesqui Bras Odontopediatria Clín Integr. 2020; 20(supp1):e0146.

Cited by 11 publications

References 83 publications

Determinants of Acceptance of Coronavirus Disease-2019 (COVID-19) Vaccine Among Lebanese Health Care Workers Using Health Belief Model

Determinants of Acceptance of Coronavirus Disease-2019 (COVID-19) Vaccine Among Lebanese Health Care Workers Using Health Belief Model

<p>Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic</p>

<p>Strategies to Prevent Healthcare-Associated Infections: A Narrative Overview</p>

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