&lt;p&gt;Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic&lt;/p&gt;

Samad, Nandeeta; Sodunke, Temitayo Eniola; Banna, Hasan Al; Sapkota, Ashmita; Fatema, Aneeka Nawar; Iskandar, Katia; Jahan, Dilshad; Hardcastle, Timothy Craig; Nusrat, Tanzina; Chowdhury, Tajkera Sultana; Haque, Mainul

doi:10.2147/rmhp.s281388

Cited by 17 publications

(15 citation statements)

References 231 publications

(358 reference statements)

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“…Other investigational treatments for COVID-19 involve convalescent plasma (CP) from previously infected and recovered patients. 171 Duan et al (2020), administering CP from donors with a high level of SARS-CoV-2 antibodies early in the disease, found this effective in boosting immunity among ten COVID-19 patients enrolled in the clinical trial. 172 In addition, CP produced faster recovery among 49 COVID-19 patients in a retrospective observational study.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications

Abubakar¹,

Sani²,

Godman³

et al. 2020

IDR

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Section: Resultsmentioning

confidence: 99%

Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications

Abubakar¹,

Sani²,

Godman³

et al. 2020

IDR

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“…318 Besides Taiwan, Hong Kong, and Singapore have also heavily invested in the PHC after the SARS epidemic. 332 These Asian nations equally controlled and manage COVID-19 much better than other countries of the globe. 333 Japan established a universal health care system back in 1961.…”

Section: Primary Health Care In the Management Of The Global Pandemicmentioning

confidence: 99%

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Samad¹,

Sodunke²,

Abubakar³

et al. 2021

JIR

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The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for COVID-19 management. Also, there is an urgent need to discover effective medicines, prevention, and control methods because of the harsh death toll from this novel coronavirus infection. Acute respiratory tract infections, significantly lower respiratory tract infections, and pneumonia are the primary cause of millions of deaths worldwide. The role of micronutrients, including trace elements, boosted the human immune system and was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, and folate; microelement including zinc, iron, selenium, magnesium, and copper; omega-3 fatty acids as eicosapentaenoic acid and docosahexaenoic acid plays essential physiological roles in promoting the immune system. Furthermore, zinc is an indispensable microelement essential for a thorough enzymatic physiological process. It also helps regulate gene-transcription such as DNA replication, RNA transcription, cell division, and cell activation in the human biological system. Subsequently, zinc, together with natural scavenger cells and neutrophils, are also involved in developing cells responsible for regulating nonspecific immunity. The modern food habit often promotes zinc deficiency; as such, quite a few COVID-19 patients presented to hospitals were frequently diagnosed as zinc deficient. Earlier studies documented that zinc deficiency predisposes patients to a viral infection such as herpes simplex, common cold, hepatitis C, severe acute respiratory syndrome coronavirus (SARS-CoV-1), the human immunodeficiency virus (HIV) because of reducing antiviral immunity. This manuscript aimed to discuss the various roles played by zinc in the management of COVID-19 infection.

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“…One children had severe symptoms, but after therapy, the child showed milder symptoms. Luigi Concetti performed a similar therapy in 1900 on two children affected with diphtheria in Rome, Italy [6,32]. After that, CP therapy was used for treating many diseases like MERS, Ebola, SARS etc.…”

Section: History Of Convalescent Plasmamentioning

confidence: 99%

Convalescent Plasma: An Evidence-Based Old Therapy to Treat Novel Coronavirus Patients

Shubham¹,

Devi²,

Sarkar³

et al. 2022

Biotechnology to Combat COVID-19

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Novel Coronavirus (nCoV-2019) is a highly infectious viral outbreak that has so far infected more than 110 million people worldwide. Fast viral transmission and high infection rates have severely affected the entire population, especially the old aged and comorbid individuals leaving significantly less time to find some effective treatment strategy. In these challenging times, convalescent plasma (CP) therapy came as a ray of hope to save humankind. It is a form of passive immunization that has been used to treat various infectious diseases since 1890, including the 1918 Spanish flu, 2002/03 SARS-CoV, 2009 H1N1, 2012 MERS-CoV, and 2014 Ebola outbreak. The transfusion includes administration of CP containing a high value of neutralizing antibodies against the virus in hospitalized patients. This chapter summarizes the potential outcome of CP therapy in the treatment of nCoV-2019 patients.

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<p>Convalescent Plasma Therapy for Management of COVID-19: Perspectives and Deployment in the Current Global Pandemic</p>

Cited by 17 publications

References 231 publications

Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications

Systematic Review on the Therapeutic Options for COVID-19: Clinical Evidence of Drug Efficacy and Implications

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Convalescent Plasma: An Evidence-Based Old Therapy to Treat Novel Coronavirus Patients

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