An overview of mycotoxins, their pathogenic effects, foods where they are found and their diagnostic biomarkers

Silva, João Victor Batista da; Oliveira, Carlos Augusto Fernandes de; Ramalho, Leandra Náira Zambelli

doi:10.1590/fst.48520

Cited by 12 publications

(11 citation statements)

References 101 publications

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“…Spôsobujú nielen zdravotné problémy ľudí, ale často bývajú príčinou ekonomických strát v chovoch zvierat. Mykotoxíny sú skrytou hrozbou, pretože sa môžu nachádzať v krmovinách, krmivách, v produktoch živočíšneho a rastlinného pôvodu, a tiež v potravinách 1 . Konzumácia krmív a potravín kontaminovaných mykotoxínmi môže negatívne ovplyvniť zdravotný stav zvierat a ľudí.…”

Section: úVodunclassified

“…Aflatoxíny sú nízkomolekulárne látky s molekulovou hmotnosťou v rozsahu 299 až 346 g mol -1 (obr. [1][2][3][4]. Toxikologicky najvýznamnejší je alfatoxín B 1 (C 17 H 12 O 6 ) s molekulovu hmotnosťou 312,3 a chemickým názvom (6aR-cis)-2,3,6a,9a-tetrahydro-4--metoxy-cyklopenta[c]furo[3´2´:4,5]furo [2,3-h][1]benzopyran-1,11-dión.…”

Section: Najvýznamnejšie Sekundárne Metabolity Rodu Aspergillusunclassified

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The Most Important Secondary Metabolites of the Genus Aspergillus

2022

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The presence of Aspergillus mycotoxins has been confirmed in various feed and food. They represent a hidden threat that cannot be completely prevented. In animal husbandry, they impair their productive health and, in human nutrition, they can cause acute or chronic health complications. This article provides an overview of the most important secondary metabolites of the genus Aspergillus in terms of their occurrence, toxicity and physico-chemical properties.

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Section: úVodunclassified

Section: Najvýznamnejšie Sekundárne Metabolity Rodu Aspergillusunclassified

The Most Important Secondary Metabolites of the Genus Aspergillus

2022

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“…José (2013) (2020) verificaram contagens de 4,5 UFC/g e 3,95 x 10 UFC/g de bolores e leveduras em amostras vendidas estabelecimentos comerciais da cidade de Querétaro -México e Zhenjiang-China, respectivamente. A presença expressiva de fungos é preocupante pois, muitas espécies de fungos podem sintetizar micotoxinas com potencial para causar danos à saúde humana (Silva et al, 2021).…”

Section: Análise Microbiológicaunclassified

Análise físico-química e microbiológica de tomates cereja (Solanum lycopersicum var. cesariforme) comercializados em empórios de Manaus-AM

Dantas

Maia

Moreno

et al. 2021

RSD

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A produção e o consumo de tomate cereja (Solanum lycopersicum var. cesariforme) vêm crescendo devido as suas propriedades nutricionais e potencial gastronômico. Entretanto, há poucos dados reportando as características intrínsecas e a qualidade sanitária de tomates cereja comercializados em estados da região Norte do Brasil. O objetivo deste trabalho foi avaliar as propriedades físico-químicas e a qualidade microbiológica de tomates cereja comercializados em empórios da cidade de Manaus-AM. Um quantitativo de 10 amostras de tomate cereja foi adquirido em empórios das Zonas Oeste (ZO) e Centro Sul (ZCS) de Manaus. Esses frutos foram avaliados quanto as suas propriedades físico-químicas (umidade, pH, sólidos solúveis totais expressos em ºBrix, acidez titulável expressa em ácido cítrico e ratio) e qualidade microbiológica (contagens de bolores e leveduras, Escherichia coli e avaliação da presença de Salmonella sp.) A média do teor de umidade foi de 94,74% e pH variou de 5,44 (ZO4) a 4,87 (ZCS1). O conteúdo significativo de sólidos solúveis totais (7,60 °Brix) foi verificado na amostra ZCS. A acidez em ácido cítrico foi, em média, de 0,39%. Os valores de ratio variaram de 26,67 (ZO4) a 8,28 (ZO1). Na avaliação da qualidade sanitária, foram verificadas contagens 2x102 UFC/g a 5 x 103 UFC/g para bolores e leveduras, mas não foi observada contaminação por E. coli e Salmonella sp. Os tomates cereja comercializados na cidade de Manaus podem ser fontes de fungos produtores de toxinas e, portanto, a qualidade microbiológica desses frutos deve ser monitorada para evitar danos à saúde do consumidor.

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“…The main pollution sources of ZEN are grains, including major crops such as corn, wheat, and sorghum, as well as milk and spices [ 6 , 7 , 8 ]. ZEN contaminates 25% of the world’s food [ 9 ] and many countries have limited the content of ZEN in variety of crops and food [ 10 ]. For examples, the maximum residue limits for ZEN in corn are 60 [ 11 ] and 20 μg/kg [ 12 ] in China and EU, respectively.…”

Section: Introductionmentioning

confidence: 99%

Evanescent Wave Optical-Fiber Aptasensor for Rapid Detection of Zearalenone in Corn with Unprecedented Sensitivity

et al. 2022

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Zearalenone (ZEN) is a common mycotoxin pollutant found in agricultural products. Aptamers are attractive recognition biomolecules for the development of mycotoxin biosensors. Even though numerous aptasensors have been reported for the detection of ZEN in recent years, many of them suffer from problems including low sensitivity, low specificity, tedious experimental steps, high-cost, and difficulty of automation. We report here the first evanescent wave optical-fiber aptasensor for the detection of ZEN with unprecedented sensitivity, high specificity, low cost, and easy of automation. In our aptasensor, a 40-nt ZEN-specific aptamer (8Z31) is covalently immobilized on the fiber. The 17-nt fluorophore Cy5.5-labeled complementary DNA strand and ZEN competitively bind with the aptamer immobilized on the fiber, enabling the signal-off fluorescent detection of ZEN. The coating of Tween 80 enhanced both the sensitivity and the reproducibility of the aptasensor. The sensor was able to detect ZEN spiked-in the corn flour extract with a semilog linear detection range of 10 pM-10 nM and a limit of detection (LOD, S/N = 3) of 18.4 ± 4.0 pM (equivalent to 29.3 ± 6.4 ng/kg). The LOD is more than 1000-fold lower than the maximum ZEN residue limits set by China (60 μg/kg) and EU (20 μg/kg). The sensor also has extremely high specificity and showed negligible cross-reactivity to other common mycotoxins. In addition, the sensor was able to be regenerated for 28 times, further decreasing its cost. Our sensor holds great potential for practical applications according to its multiple compelling features.

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An overview of mycotoxins, their pathogenic effects, foods where they are found and their diagnostic biomarkers

Cited by 12 publications

References 101 publications

The Most Important Secondary Metabolites of the Genus Aspergillus

The Most Important Secondary Metabolites of the Genus Aspergillus

Análise físico-química e microbiológica de tomates cereja (Solanum lycopersicum var. cesariforme) comercializados em empórios de Manaus-AM

Evanescent Wave Optical-Fiber Aptasensor for Rapid Detection of Zearalenone in Corn with Unprecedented Sensitivity

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