Characteristics of glucose oxidase immobilized on Magnetic Chitosan Nanoparticles

Afjeh, Maryam Ein Ali; Pourahmad, Rezvan; Akbari‐adergani, Behrouz; Azin, Mehrdad

doi:10.1590/fst.32618

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Breast cancer (BC) is the most common malignancy and one of the leading causes of cancer death among women worldwide (Mavaddat et al, 2019). Potential risk factors for BC include high body mass index, older age, family history, long menstrual periods, use of oral contraceptives, and exposure to radiation (Lee et al, 2019;Morra et al, 2019;Ein Ali Afjeh et al, 2020;Hossen et al, 2021). The vast majority of breast tumors are originated from glandular epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of breast-conserving surgery and modified radical mastectomy on quality of life of early breast cancer patients

Liu

Luo

2022

Food Sci. Technol

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We aimed to explore the clinical efficacy of breast-conserving surgery and modified radical mastectomy on the quality of life (QoL) in patients with early breast cancer. A total of 100 patients treated with breast-conserving surgery (BCS) were recruited in the BCS group, and 100 patients treated with modified radical mastectomy (MRM) in the MRM group. Our results showed that patients had significantly shorter operation time and hospital stay, smaller incisions, and less intraoperative blood loss in the BCS group than in the MRM group. The total complication rate was significantly lower in the BCS. The rate of good-toexcellent aesthetic outcomes in the BCS group was significantly. At one year and three years after surgery, the QoL in the BCS group was significantly higher than that in the MRM group (P<0.0001). In conclusion, BCS is as effective as MRM in early breast cancer, but confers better perioperative and aesthetic outcomes, higher QoL, and lower postoperative complication rate.

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Section: Introductionmentioning

confidence: 99%

Effect of breast-conserving surgery and modified radical mastectomy on quality of life of early breast cancer patients

Liu

Luo

2022

Food Sci. Technol

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“…In addition, the situation of mental health in medical workers in China can also not be optimistic and the rate of suicides of doctors was dramatically increased in recent years. Moreover, food have significant effect on the health of medical workers (Yildiz et al, 2021;Hossen et al, 2021;Ein Ali Afjeh et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The implications of organizational environment questionnaire for the assessment of occupational injury among medical workers

et al. 2022

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Organization environment has significant influence on occupational health among medical workers. In current study, based on previous established questionnaires, we constructed a new questionnaire to evaluate the effects of organizational environment on occupational injury of medical workers. In a large-scale of investigation, a total of 2350 medical workers from 54 hospitals in Zhuhai city, China, were surveyed by the new questionnaire, and 2111 (91.2%) questionnaires were used for final analysis. The average score of organization environment of medical workers questionnaire was 91.33 ± 21.95. We found that as compared with the average levels, medical workers have higher incidences of behavioral symptoms such as depressed mood, obsessional thinking, and anxiety and so on. We also demonstrated the questionnaire scores correlated with the incidence of occupational disease, occupational injuries and the scores of SCL-90, implying its potential application to objectively measure the conditions of medial safety of medical workers in China. In all, we concluded that organizational environment has important implications on the assessment of occupational health of medical workers.

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“…The PDA is used as a detector at a wavelength of 276 nm. The concentration of insulin in the injected sample was determined by the developed method with the regression coefficient (r 2 = 0.99)[24]. The amount of GOx was determined by subtracting the insulin concentration from the total amount of protein.…”

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confidence: 99%

Oral Glucose-Responsive Nanocarrier System for Management of Diabetes

et al. 2022

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Background:The regulation of postprandial blood glucose concentration in a diabetic person is a toilsome task by the conventional approaches. The continuous monitoring and subcutaneous injection of insulin are always imperative for diabetes management. To overcome the hurdle associated with the conventional system, a glucose-responsive nanoparticle (NP)-based approach was developed for oral insulin administration. The objective of the work is the formulation and characterization of a nanocarrier-based bio-responsive, self-regulated oral insulin drug delivery system. Methods:The mannose ligand-conjugated NPs were prepared by the inotropic gelation method in which insulin and glucose oxidase enclosed alginate nanocarrier cross-linked by tripolyphosphate. The prepared NPs were filled into the enteric-coated capsule and their release profile was determined at different pH and glucose concentrations. NPs were characterized by size distribution, % drug entrapment, enzyme activity, and in vivo and in vitro drug release studies. Results:The average size, surface potential, % drug entrapment of optimized NPs were 245.52 ± 3.37 nm, 22.12 ± 2.13, and 76.15±1.3%, respectively. The release of insulin from optimized NPs (GOx-ALG-MCNPs) (98.56±0.06%) occurs only at higher sugar concentrations (≥ 400 mg/dL) and prevents the release at low sugar concentrations (< 100 mg/dL). The enteric capsule shell protected the formulation to the gastric environment upon oral administration and directed them into the intestine. Mucoadhesion characteristics of NPs prolonged intestinal retention to make them available for cellular uptake. Glucose sensitivity and glucose-dependent effect on different pH environments study revealed that NPs released the drug only at higher concentrations of sugar solution while inhibiting the release at normal and lower sugar concentrations. Besides, compared to other prepared formulations, the GOx-ALG-MCNPs displayed controlled insulin release in response to glucose concentration.Conclusions: An important finding of GOx-ALG-MCNPs is autoregulating, glucose-responsive behavior imparting a significantly controlled lowering of blood glucose in an animal model. The findings reveal that the developed glucose-responsive NPs may prove to be a potential strategy for oral insulin delivery.

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Characteristics of glucose oxidase immobilized on Magnetic Chitosan Nanoparticles

Cited by 8 publications

References 32 publications

Effect of breast-conserving surgery and modified radical mastectomy on quality of life of early breast cancer patients

Effect of breast-conserving surgery and modified radical mastectomy on quality of life of early breast cancer patients

The implications of organizational environment questionnaire for the assessment of occupational injury among medical workers

Oral Glucose-Responsive Nanocarrier System for Management of Diabetes

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