Adult linear IgA bullous dermatosis: report of three cases

Machado, Taila Yuri Siqueira; Enokihara, Mílvia Maria Simões e Silva; Iida, Tatiana Miyuki; Porro, Adriana María

doi:10.1590/abd1806-4841.20187304

Cited by 9 publications

(16 citation statements)

References 12 publications

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“…The most characteristic clinical features of LABD are polycyclic, grouped blisters with rosette configuration 5. Both humoral and cellular immune responses are probably involved in the pathogenesis of this disease.…”

Section: Discussionmentioning

confidence: 99%

Topical imiquimod-induced linear IgA bullous dermatosis

et al. 2019

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A 68-year-old woman was referred to the unit of dermatology for a large basal cell carcinoma on the chin. She was treated with imiquimod cream 5%, and 4 weeks after she developed isolated and grouped tense serum-filled vesicles and bullae on lips, nose, scalp, ankles and lumbar area, and then expanded to the whole body. Histological examination was consistent with a subepidermal bullous dermatosis. Moreover, direct immunofluorescence showed linear deposition of IgA at the basement membrane zone supporting the diagnosis of linear IgA bullous dermatosis (LABD). Dapsone 50 mg/day was administered, and the lesions gradually improved within some weeks, and no new lesions appeared. The temporal relationship between the application of the drug and the development of the disease indicates a role of this topical agent in triggering LABD.

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Section: Discussionmentioning

confidence: 99%

Topical imiquimod-induced linear IgA bullous dermatosis

et al. 2019

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“…The latter are generally tense and may have an annular or arcuate configuration or rosette pattern or bead-like appearance when new bullous lesions arise at the periphery of previous lesions. 46,62,63 This clinical characteristic occurs more frequently in children than in adults. 64…”

Section: Linear Iga Bullous Dermatosismentioning

confidence: 99%

“…The disease can affect the flexor surfaces of limbs and chest, as in bullous pemphigoid, or the extensor regions of the limbs, as in dermatitis herpetiformis. 46,62 Urticated papules, similar to urticaria, and excoriated papulonodular lesions may also be seen, such as in prurigo. 63,65…”

Section: Linear Iga Bullous Dermatosismentioning

confidence: 99%

“…In some patients, LABD is not adequately controlled by these medications or dapsone alone, but the combination with corticosteroids and immunosuppressants, or both, such as azathioprine, mycophenolate mofetil, cyclosporine, cyclophosphamide, and topical tacrolimus may be necessary, mainly due to the side effects of dapsone, which limits its daily dose. 48,57,62,72 There are reports of the benefits of colchicine. 73,74…”

Section: Linear Iga Bullous Dermatosismentioning

confidence: 99%

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Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis - Brazilian Society of Dermatology

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Dimatos

Porro

et al. 2019

An. Bras. Dermatol.

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Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors’ experience, aiming at the treatment orientation of these diseases in Brazil. Dermatitis herpetiformis is a cutaneous manifestation of celiac disease, and can be controlled with a gluten-free diet and dapsone. On the other hand, linear IgA bullous dermatosis arises spontaneously or is triggered by drugs, and can be controlled with dapsone, but often requires the association of systemic corticosteroids and eventually immunosuppressants.

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“…The lower abdomen, genital area, buttocks and thighs are frequently affected. 3,4 In A-LABD, the distinctive annular or 'string of pearls' clustering is less common, 5,6 and clinical presentation is diverse and can mimic bullous pemphigoid, dermatitis herpetiformis and mucous membranes pemphigoid. A-LABD is more commonly triggered by drugs 7 and has a chronic, non-remitting course in comparison with CBDC, children usually have a better response to therapy, with definite remission after 3-6 years.…”

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confidence: 99%