Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that
usually has an excellent prognosis in childhood; however, its control is more
difficult in adults. It presents heterogeneous clinical manifestations and is
frequently confused with other bullous diseases such as bullous pemphigoid and
Duhring’s dermatitis herpetiformis. Dermatologists’ awareness of this disease
contributes to early diagnosis and appropriate treatment. We thus report three
cases of linear immunoglobulin A dermatosis in adults.
Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike
other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely
associated with malignant neoplasms. The majority of squamous cell carcinoma
develop in linear or multiple epidermal nevus and rarely in solitary epidermal
nevus. In general, the prognosis is favorable. We report a case of
well-differentiated invasive squamous cell carcinoma arising from a multiple
verrucous epidermal nevus. Although there is no consensus on prophylactic
removal of epidermal nevus, its removal and biopsy should be considered if
changes occur.
OBJECTIVES: This study aims to analyze data on the epidemiology, treatment and course of bullous pemphigoid in 50 patients and compare findings to the data already available in the literature. METHODS: Data were collected retrospectively through medical records and analyzed statistically. A review of the literature was conducted using articles indexed in the MEDLINE (via PubMed) database. RESULTS: The mean age at diagnosis was 71.1 years. Comorbidities were observed in almost all cases, and the association between bullous pemphigoid and neurological diseases was present in 18% of patients, in agreement with recent data in the literature. CONCLUSION: Care of comorbidities, especially neurological diseases, which increase the mortality of patients with bullous pemphigoid, is thus essential.
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