Topical imiquimod-induced linear IgA bullous dermatosis

Abstract

A 68-year-old woman was referred to the unit of dermatology for a large basal cell carcinoma on the chin. She was treated with imiquimod cream 5%, and 4 weeks after she developed isolated and grouped tense serum-filled vesicles and bullae on lips, nose, scalp, ankles and lumbar area, and then expanded to the whole body. Histological examination was consistent with a subepidermal bullous dermatosis. Moreover, direct immunofluorescence showed linear deposition of IgA at the basement membrane zone supporting the diagnosis of linear IgA bullous dermatosis (LABD). Dapsone 50 mg/day was administered, and the lesions gradually improved within some weeks, and no new lesions appeared. The temporal relationship between the application of the drug and the development of the disease indicates a role of this topical agent in triggering LABD.

A propósito de un caso: enfermedad IgA lineal de la infancia

“…Es una enfermedad de presentación rara con discreto predominio por el sexo femenino. Su etiopatogenia no está aclarada, ha sido asociada a fármacos 4,5 como Vancomicina, Litio, Fenitoína, Trimetoprim-Sulfametoxazol, Furosemida, Diclofenaco, Captopril… Cabe destacar que en la mayoría de pacientes con dermatosis IgA inducida por fármacos coexistían otras enfermedades (neoplasias, dia-A propósito de un caso: enfermedad IgA lineal de la infancia CASO CLÍNICO Imágenes 1 y 2. Lesiones ampollosas con característica imagen en collar de perlas.…”