Giant cell tumors of the tendon sheath in the left hallux

Kondo, Rogério Nabor; Pavezzi, Priscila Daiane; Crespigio, Jefferson; Okamura, Hélio

doi:10.1590/abd1806-4841.20165769

Cited by 3 publications

(5 citation statements)

References 6 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The etiology and pathogenesis of GCTTSs are still unclear, but might be related to trauma, inflammatory response, lipid metabolism, hyperplastic changes, chromosomal abnormalities, and other factors 15–18 . The increased activity of the epidermal growth factor and platelet‐derived growth factor may also contribute to the respective synovitis 19–21 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Giant cell tumor of tendon sheath: A report of 216 cases

Huang

Li²,

Wang

et al. 2022

J Cutan Pathol

View full text Add to dashboard Cite

Background In this article on giant cell tumor of tendon sheath (GCTTS), we intend to summarize and analyze the clinical and pathological features of GCTTS hoping to improve clinical management and patient treatment. Methods The study retrospectively reviewed 216 patients of GCTTS, registered at the Affiliated Hospital of Southwest Medical University from January 2010 to December 2020. These cases were diagnosed by surgical excision. The clinicopathological features and the prognosis were reviewed in the light of the current literature. Results Of these 216 GCTTS patients, 72 were males (33.3%) and 144 females (66.7%), with a ratio male‐to‐female of 1:2. The patients' age ranged from 5 to 82, the average being 41.5 years at diagnosis. A total of 96 cases (44.4%) occurred in the hand region, followed by 35 cases (16.2%) in the knee, 32 cases (14.8%) in the foot, 25 cases (11.6%) in the ankle, 12 cases (5.6%) in the wrist, 12 cases (5.6%) in the leg, 2 cases (0.9%) in the head, 1 case (0.5%) in the forearm, and 1 case (0.5%) inside and outside the spinal channel. Histopathology mainly revealed large synovial‐like monocytes, small monocytes, and osteoclast‐like giant cells. Conclusion Our results confirm that GCTTS predominantly occurs in the hands of young women. Complete surgical resection with long‐term follow‐up is the preferred management.

show abstract

Section: Discussionmentioning

confidence: 99%

“…PathogenesisThe etiology and pathogenesis of GCTTSs are still unclear, but might be related to trauma, inflammatory response, lipid metabolism, hyperplastic changes, chromosomal abnormalities, and other factors [15][16][17][18]. F I G U R E 1 Histopathological and cytopathological features of GCTTS.…”

mentioning

confidence: 99%

Giant cell tumor of tendon sheath: A report of 216 cases

Huang

Li²,

Wang

et al. 2022

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…At present, the specific etiology of the disease is unclear and may be related to trauma, metabolic abnormalities, or related factors. 6,7 In this study, one child had a history of trauma, but whether there is an association warrants further study. Previous studies have found that TGCT is a type of tumor associated with the overexpression of colony-stimulating factor-1 (CSF-1); 8 it is most commonly caused by the t(1;2) translocation, which fuses the CSF-1 gene on chromosome 1 with the type VI collagen promoter gene on chromosome 2 (resulting in the VI collagen α3-CSF-1 fusion gene).…”

Section: Discussionmentioning

confidence: 88%

Localized tenosynovial giant cell tumor in children

Xia

Sun

et al. 2023

Journal of Children's Orthopaedics

View full text Add to dashboard Cite

Background: To investigate the clinical characteristics and surgical efficacy of localized tenosynovial giant cell tumors in children. Methods: The clinical data, surgery, and follow-up results of 17 children with localized tenosynovial giant cell tumors who visited our hospital from 2011 to 2021 were collected for statistical analysis. Results: The median patient age was 7 years and 8 months, and the ratio of males to females was 1.43 (10/7). The predilection of disease was similar in hands and feet, and the common presenting symptom was mass. One patient experienced recurrence after surgery, and one child had postoperative functional limitations. Conclusion: Extremities are common sites of localized tenosynovial giant cell tumors in children. Complete surgical resection helps reduce the recurrence rate. Level of evidence: Level III

show abstract

“…[ 7 , 12 ] GCT-TS is also termed tenosynovial giant cell tumor, pigmented nodular tenosynovitis, xanthogranuloma, benign synovioma, and fibrous xanthoma of synovium. [ 2 , 13 , 14 ] The GCT-TS is a benign but locally aggressive tumor that arises from the synovial membrane of joints, tendon sheaths, and bursae. [ 14 ] Although any joint can be affected, involvement of the TMJ was reported very rarely.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 , 13 , 14 ] The GCT-TS is a benign but locally aggressive tumor that arises from the synovial membrane of joints, tendon sheaths, and bursae. [ 14 ] Although any joint can be affected, involvement of the TMJ was reported very rarely. [ 11 ] The present study added 2 rare cases to the growing body of literature characterizing the clinical features and treatment of GCT-TS in the TMJ already including approximately 80 and 30 cases in the English- and Chinese-language literature, respectively, to our knowledge, enhancing the understanding about this rare disease.…”

Section: Discussionmentioning

confidence: 99%

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

HONG¹,

Wang²,

Lin³

et al. 2018

Medicine

View full text Add to dashboard Cite

Rationale:Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare.Patient concerns:We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital.Diagnosis:Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5.8 × 3.8 × 4.6 cm for case 1 and 4.2 × 3.2 × 4.3 cm for case 2, respectively. Magnetic resonance imaging (MRI) findings showed a mass of 6.1 × 4.0 × 5.1 cm and 5.3 × 3.6 × 3.3 cm, respectively. Postoperative pathological examination revealed the diffuse multinucleated giant cells accompanied with synovial cells in the diffuse arrangement. Immunohistochemical examination showed CD68 (+), Vim (+), S-100 (-) and 2% of Ki-67 proliferation index. These characteristics are in line with the diagnosis of the diffuse GCT-TS in the TMJ.Interventions:Both cases underwent the gross total resection followed by radiation therapy.Outcomes:Two patients experienced no recurrence after follow-up of 1 to 2 year(s).Lessons:Diffuse GCT-TS in the TMJ is very rare. Clinicians should keep in mind the possibility of the GCT-TS when aggressive lesions involve the TMJ and adjacent bone destruction was found. Careful pre- and postoperative examinations and complete resection are the factors that lead to its optimal treatment, significantly reducing its recurrence rate.

show abstract

Giant cell tumors of the tendon sheath in the left hallux

Cited by 3 publications

References 6 publications

Giant cell tumor of tendon sheath: A report of 216 cases

Giant cell tumor of tendon sheath: A report of 216 cases

Localized tenosynovial giant cell tumor in children

Diffuse giant cell tumors of the tendon sheath in temporomandibular joint

Contact Info

Product

Resources

About