Giant cell tumor of tendon sheath: A report of 216 cases

Abstract

Background In this article on giant cell tumor of tendon sheath (GCTTS), we intend to summarize and analyze the clinical and pathological features of GCTTS hoping to improve clinical management and patient treatment. Methods The study retrospectively reviewed 216 patients of GCTTS, registered at the Affiliated Hospital of Southwest Medical University from January 2010 to December 2020. These cases were diagnosed by surgical excision. The clinicopathological features and the prognosis were reviewed in the light of the current literature. Results Of these 216 GCTTS patients, 72 were males (33.3%) and 144 females (66.7%), with a ratio male‐to‐female of 1:2. The patients' age ranged from 5 to 82, the average being 41.5 years at diagnosis. A total of 96 cases (44.4%) occurred in the hand region, followed by 35 cases (16.2%) in the knee, 32 cases (14.8%) in the foot, 25 cases (11.6%) in the ankle, 12 cases (5.6%) in the wrist, 12 cases (5.6%) in the leg, 2 cases (0.9%) in the head, 1 case (0.5%) in the forearm, and 1 case (0.5%) inside and outside the spinal channel. Histopathology mainly revealed large synovial‐like monocytes, small monocytes, and osteoclast‐like giant cells. Conclusion Our results confirm that GCTTS predominantly occurs in the hands of young women. Complete surgical resection with long‐term follow‐up is the preferred management.

Locally Invasive Pigmented Villonodular Synovitis of the Wrist Treated by Arthroscopic Resection and Bone Grafting

“…Only two cases complained of tenderness likely due to proximity to a digital nerve. This corresponds to another large case cohort study 6 of 216 patients with a male:female ratio of 1:2 with all of them having slow growing painless masses. For our patient, the escalating pain was likely due to progressive mass effect of the tumor onto the joint capsule and erosion of the scaphoid and radiocarpal joint.…”

“…[14][15][16] Surgical excision is deemed to be the treatment of choice as this tumor is not known to resolve spontaneously. 6 Table 1 is a literature review of two large cohort studies showing the treatment of PVNS located in the wrist, none of which were performed via arthroscopy. A large cohort study showed most of such recurrences occurring within 4 years of the index surgery, with a mean time of 25 months.…”

“…Although benign, it is locally aggressive with a high recurrence rate (7%–44%) 14–16 . Surgical excision is deemed to be the treatment of choice as this tumor is not known to resolve spontaneously 6 . Table 1 is a literature review of two large cohort studies showing the treatment of PVNS located in the wrist, none of which were performed via arthroscopy.…”

“…Conceptualization: L.B., Writing -Original Draft: R.L, X.S.G, Writing-Review & Editing: R.L, L.B, Visualization: R.L, Study Supervision: L.B. Data not available No recurrence at average 54 months f/u (37-72 months) Huang 6 12 Open surgical excision (12) Data not available Data not available…”

Sonographic features of diffuse giant cell tumor of the tendon sheath in the shoulder: A case report

“…3 GCTTS is rare in children and has a higher predilection in women than in men. 4 The typical clinical presentation is an asymptomatic, slow-growing mass that may be painful in some cases.…”