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Objective: To evaluate the effect of beinaglutide on weight loss and plasma protein patterns of inflammation/obesity relevant cytokines and biomarkers. Materials and methods: This study involved 36 adult patients with a body mass index (BMI) of ≥ 24 kg/m 2 and T2DM. Beinaglutide was administered for three months. Changes in body weight, fasting plasma glucose (FPG) level, 2 h postprandial plasma glucose (2h-PG) level, glycosylated hemoglobin (HbA1c) level, BMI and visceral and subcutaneous fat areas were measured at baseline and after three months of treatment. In addition, relevant inflammation/obesity cytokines and biomarkers were measured. Results: After three months, beinaglutide treatment led to significant changes, including in body weight, BMI, FPG level, HbA1c level, visceral and subcutaneous fat areas. In addition, serpin E1, leptin, C-reaction protein (CRP) and tumor necrosis factor-α (TNF-α) also decreased significantly. The plasma protein concentrations of CRP (Log2 transformed) were found to be positively correlated with the percentage of weight loss (R = 0.514 and p -value = 0.021). Conclusion: Beinaglutide treatment resulted in weight loss, plasma glucose control and anti-inflammatory effects in patients with T2DM and overweight/ obesity.

Background: This case report describes a rare and unfortunate incident involving a 14-month-old child who was exposed to mercury. The purpose of this case report is to share the unique and typical image findings of residual mercury in a foreign body, which can aid clinicians in identifying similar cases and providing effective treatment. Case presentation: A 14-month-old child presented with mercury residue in their body, following its discovery in the child's bed. Urine tests showed elevated levels of mercury, and X-rays revealed a large amount of mercury in the child's upper arms and lungs. The patient underwent timely surgical treatment, and while they are currently recovering, they still require ongoing medication and additional treatments. Conclusions: Pediatric exposure to toxic substances such as mercury can have significant consequences for young patients. Early recognition and prompt intervention can prevent significant morbidity and mortality associated with toxicity. Clinicians should be aware of the risks and potential complications associated with heavy metal exposure and take appropriate measures to protect susceptible populations. In addition, sharing image data of unique and typical cases can aid clinicians in identifying similar cases and providing effective treatment.

Background: To investigate the clinical characteristics and surgical efficacy of localized tenosynovial giant cell tumors in children. Methods: The clinical data, surgery, and follow-up results of 17 children with localized tenosynovial giant cell tumors who visited our hospital from 2011 to 2021 were collected for statistical analysis. Results: The median patient age was 7 years and 8 months, and the ratio of males to females was 1.43 (10/7). The predilection of disease was similar in hands and feet, and the common presenting symptom was mass. One patient experienced recurrence after surgery, and one child had postoperative functional limitations. Conclusion: Extremities are common sites of localized tenosynovial giant cell tumors in children. Complete surgical resection helps reduce the recurrence rate. Level of evidence: Level III