Penile ulcer as a specific clinical manifestation of Waldenstrom’s macroglobulinemia

Abstract

Waldenstrom’s macroglobulinemia is considered a lymphoma by the World Health Organization. Cutaneous lesions, particularly of a specific type, are rare occurring in 5% of patients. What draws attention in this case is the unusual cutaneous clinical manifestation and its location on the genitals, which has not been described in researched literature, therefore imposing differential diagnosis with other etiologies of genital ulcers.

Extramedullary Waldenström Macroglobulinemia Presenting as a Subcutaneous Penile Mass

“…Nonetheless, the mass can be characterised as neoplastic from the presence of lymphoplasmacytic cells (Figure 3), making this a rare finding due to the particular composition and location of the mass. Penile presentation of WM is extremely rare, with only one case identified by our literature search [3]. Additionally, in the case described by Oliveria et al [3], the lesion was a cutaneous manifestation described as a 4 cm verrucous ulcer.…”

“…Penile presentation of WM is extremely rare, with only one case identified by our literature search [ 3 ]. Additionally, in the case described by Oliveria et al [ 3 ], the lesion was a cutaneous manifestation described as a 4 cm verrucous ulcer. Our patient had a history of WM with recurrence occurring at the base of the penis as a subcutaneous mass.…”

“…The most common type of penile malignancy is squamous cell carcinoma related to human papillomavirus, while metastases, soft tissue sarcomas, and lymphomas are less common causes [ 1 ]. Waldenström macroglobulinemia (WM) of the penis is rare, with only one other case reported in the literature that encompassed cutaneous and systemic manifestations, typical findings in delayed-onset WM [ 3 ]. Here, we report a case of WM relapse that was discovered in an asymptomatic individual after a histopathological workup of an insidious subcutaneous penile mass.…”