Extramedullary Waldenström Macroglobulinemia Presenting as a Subcutaneous Penile Mass

Abstract

Primary penile malignancy is a rare occurrence in the United States, with squamous carcinoma being the most common aetiology. Non-squamous penile cancers are scarcely reported in the literature. We present a unique case of a 65-year-old male with a history of Waldenström macroglobulinemia (WM) previously in remission complaining of a painless subcutaneous bump on the base of the penis. Biopsy with histological and immunohistochemical analysis confirmed the recurrence of WM. This novel case illustrates an unusual presentation of the disease after being successfully managed with chemotherapy and immunotherapy in an asymptomatic individual. There is only another reported case in the literature of a patient with a similar presentation. We highlight the clinical features and presentation of this condition, including a consensus for the approach and management of non-Hodgkin's lymphomas of the penis.

Lymphoplasmacytic lymphoma relapse presenting as isolated multifocal subcutaneous adipose tissue infiltrates on 18F-FDG PET/CT

“… 6 There have been only a handful of reports of soft tissue 18 F-FDG PET LPL/WM infiltration in the central nervous system, 8 – 10 lung and pleura, skin, liver, and bowel. 7 There has been a single report of WM infiltration as a subcutaneous mass by Palmer et al 11 However, to the best of our knowledge, we report the first case of the isolated LPL presentation in subcutaneous adipose tissue, as detected on 18 F-FDG PET/CT.…”