Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma

Mendaçolli, Paola Jung; Brianezi, Gabrielli; Schmitt, Juliano Vilaverde; Marques, Mariângela Esther Alencar; Miot, Hélio Amante

doi:10.1590/abd1806-4841.20154076

Cited by 10 publications

(12 citation statements)

References 19 publications

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“…The authors suggest that these differences may be linked with the distinct clinical behaviour and growth of each lesions: the superficial and nodular BCC with prominently horizontal growth and lower degree of invasiveness, in contrast to the early and insidious invasiveness of the dermis in SBCC. 17 This histological heterogeneity supports our findings of SBCC with deeper infiltration being diagnosed later than more superficial lesions, which can be detected more easily.…”

Section: Discusionsupporting

confidence: 89%

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

Husein‐ElAhmed¹

2018

An. Bras. Dermatol.

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BackgroundThe behaviour of each basal cell carcinoma is known to be different according to the histological growth pattern. Among these aggressive lesions, sclerodermiform basal cell carcinomas are the most common type. This is a challenging-to-treat lesion due to its deep tissue invasion, rapid growth, risk of metastasis and overall poor prognosis if not diagnosed in early stages.ObjectiveTo investigate if sclerodermiform basal cell carcinomas are diagnosed later compared to non-sclerodermiform basal cell carcinoma Method: All lesions excised from 2000 to 2010 were included. A pathologist classified the lesions in two cohorts: one with specimens of non-aggressive basal cell carcinoma (superficial, nodular and pigmented), and other with sclerodermiform basal cell carcinoma. For each lesion, we collected patient's information from digital medical records regarding: gender, age when first attending the clinic and the tumor location.Results1256 lesions were included, out of which 296 (23.6%) corresponded to sclerodermiform basal cell carcinoma, whereas 960 (76.4%) were non-aggressive subtypes of basal cell carcinoma. The age of diagnosis was: 72.78±12.31 years for sclerodermiform basal cell and 69.26±13.87 years for non-aggressive basal cell carcinoma (P<.0001). Sclerodermiform basal cell carcinomas are diagnosed on average 3.52 years later than non-aggressive basal cell carcinomas. Sclerodermiform basal cell carcinomas were diagnosed 3.40 years and 2.34 years later than non-aggressive basal cell carcinomas in younger and older patients respectively (P=.002 and P=.03, respectively).Study limitationsretrospective design.ConclusionThe diagnostic accuracy and primary clinic conjecture of sclerodermiform basal cell carcinomas is quite low compared to other forms of basal cell carcinoma such as nodular, superficial and pigmented. The dermoscopic vascular patterns, which is the basis for the diagnosis of non-melanocytic nonpigmented skin tumors, may not be particularly useful in identifying sclerodermiform basal cell carcinomas in early stages. As a distinct entity, sclerodermiform basal cell carcinomas show a lack of early diagnosis compared to less-aggressive subtypes of BCC, and thus, more accurate diagnostic tools apart from dermatoscopy are required to reach the goal of early-stage diagnosis of sclerodermiform basal cell carcinomas.

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Section: Discusionsupporting

confidence: 89%

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

Husein‐ElAhmed¹

2018

An. Bras. Dermatol.

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“…Alterations in nuclear morphometry and chromatin texture are used in pathology as criteria for differentiation between healthy tissues and neoplasias 24, 31. In addition, tissues under stress, such as ultraviolet radiation, may also present nuclear alterations, usually related to the intensity of metabolic activity 24, 28. In this study, phenotypically, the genomic damage to the SFC manifested as changes in the shape of the nucleus and heterogeneity of chromatin, correlated among themselves and with progressive changes according to photoexposure and the presence of AKs, supporting the evidence for genomic instability and suggesting that these alterations occur in a simultaneous intranuclear manner.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, morphometry and nuclear texture characteristics have been studied as prognostic factors in many neoplasms 24, 25, 26, 27. Investigations on nuclear morphometry and chromatin heterogeneity have been performed on BCCs; however, there are no studies characterizing such parameters in SFC and correlating them with field activity 28 …”

Section: Introductionmentioning

confidence: 99%

Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects

Miola

Castilho

Schmitt

et al. 2019

Anais Brasileiros de Dermatologia

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BackgroundA skin field cancerization is a cutaneous area with subclinical changes resultant from chronic sun exposure, with a higher predisposition to development of pre-neoplastic and neoplastic lesions. So far, there are no well-defined objective parameters that can indicate their degree of activity.ObjectivesTo describe and compare morphometric aspects and expression of factors related to apoptosis and cell proliferation in actinic keratosis (AK), in both photoexposed and photoprotected epidermis.MethodsA cross-sectional study of patients with actinic keratosis in the forearms, biopsied at two points: the actinic keratosis and the axillary region. The biopsies of the actinic keratosis, perilesional area, and axilla were evaluated through keratinocyte intraepithelial neoplasia (KIN), and immunohistochemistry of p53, survivin, and Ki67. Nuclear morphometry of basal layer cells was performed through digital image analysis: entropy, area, perimeter, Ra, fractal dimension, circularity, color intensity, and largest diameter.ResultsThere were 13 patients included and 38 actinic keratosis biopsied. In morphometry, 1039 nuclei were analyzed, of which 228 represented axillary skin, 396 demonstrated actinic keratosis, and 415 represented the perilesional area to the actinic keratosis. There was a significant difference (p < 0.05) in all variables tested for the topographies evaluated. A significant correlation was identified between nucellar morphometric elements, KIN, proliferation markers, and apoptosis. Joint patterns of p53, Ki67, and KIN discriminated the topographies sampled.Study limitationsThis was a cross-sectional study with a small number of patients.ConclusionsThere are patterns of proliferation, resistance to apoptosis, and different cellular morphometrics between photoprotected skin and photoexposed skin. The joint expression of p53, Ki67, and KIN can characterize skin field cancerization activity.

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“…Dor abdominal 5,7,9,27,29,30,33,34,59,61,69,108,120,122,123,131 Drenagem biliar 13, 15 Fígado 13,14,27,33,37,38,63,69,121,123,127,134…”

Section: Conclusãomentioning

confidence: 99%

Conhecimento Sobre a Prevenção Do Câncer De Pele Entre Trabalhadores Em Exposição Solar Excessiva: Uma Revisão Integrativa

Sucupira¹,

Cardoso²,

Sena³

et al. 2020

Medicina: Elevados Padrões De Desempenho Técnico E Ético

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação. A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma

Cited by 10 publications

References 19 publications

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

Sclerodermiform basal cell carcinoma: how much can we rely on dermatoscopy to differentiate from non-aggressive basal cell carcinomas? Analysis of 1256 cases

Contribution to characterization of skin field cancerization activity: morphometric, chromatin texture, proliferation, and apoptosis aspects

Conhecimento Sobre a Prevenção Do Câncer De Pele Entre Trabalhadores Em Exposição Solar Excessiva: Uma Revisão Integrativa

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