2019
DOI: 10.1016/j.abd.2019.03.003 View full text |Buy / Rent full text
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Abstract: BackgroundA skin field cancerization is a cutaneous area with subclinical changes resultant from chronic sun exposure, with a higher predisposition to development of pre-neoplastic and neoplastic lesions. So far, there are no well-defined objective parameters that can indicate their degree of activity.ObjectivesTo describe and compare morphometric aspects and expression of factors related to apoptosis and cell proliferation in actinic keratosis (AK), in both photoexposed and photoprotected epidermis.MethodsA c… Show more

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“…Similar to our epidermal thickness analysis, we developed automated pipelines for detecting and segmenting cells that were positive for these molecular targets (Supplemental Figure 2). It is well established that an increase in the proliferation of keratinocytes (Ki67+) in the cancer field, particularly in regions that are distal from the dermal-epidermal junction (DEJ), correlates with an increased risk of developing keratosis 44 . Figure 5a shows representative Ki67 immunostaining of a cancer field section taken from a vehicle control animal.…”
Section: Resultsmentioning
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“…Similar to our epidermal thickness analysis, we developed automated pipelines for detecting and segmenting cells that were positive for these molecular targets (Supplemental Figure 2). It is well established that an increase in the proliferation of keratinocytes (Ki67+) in the cancer field, particularly in regions that are distal from the dermal-epidermal junction (DEJ), correlates with an increased risk of developing keratosis 44 . Figure 5a shows representative Ki67 immunostaining of a cancer field section taken from a vehicle control animal.…”
Section: Resultsmentioning
“…Riihila et al demonstrated in their study the importance of complement components C1r and C1s in cutaneous squamous cell carcinomas in terms of progression. This highlights the importance of targeted novel treatments for cSCCs [ 43 ]. Roper et al showed that PD-L1 expression is usually observed in cSCC primary tumors and in TILs (tumor-infiltrating lymphocytes).…”
Section: Discussionmentioning
“…For assessing the impact of and to establish the research directions for squamous cell carcinomas, we used the scientometric method [ 3 , 4 ]. A set of instructions was defined based on the keywords from the 76 articles we assessed [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , …”
Section: Methodsmentioning