Histological subtypes of basal cell carcinoma have biological, evolutionary
and distinct prognostic behavior. The analysis of characteristics of the
nucleus can provide data on their cellular physiology and behavior. The
authors of this study evaluated nuclear morphological parameters and
textural patterns of chromatin from different subtypes of basal cell
carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28).
The parameters were compared between neoplasms' subtypes and with
unaffected adjacent basal epithelium. Nuclear area and diameter of
sclerodermiform neoplasms were superior to the other subtypes. Chromatin's
color intensity and fractal dimension were less intense in superficial
subtypes. Nuclear roundness and chromatin's entropy presented lower values
in tumors than in normal epithelium. There was significant correlation
between morphological and textural variables of normal skin and tumors.
Morphometric elements and textural chromatin's homogeneity of basal cell
carcinomas may be related to evolutionary, biological and behavior
particularities related to each histotype.
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