Reflectance confocal microscopy of cutaneous melanoma. Correlation with dermoscopy and histopathology

Rstom, Sílvia Arroyo; Libório, Lorena Silva; Paschoal, Francisco Macedo

doi:10.1590/abd1806-4841.20153774

Cited by 7 publications

(9 citation statements)

References 10 publications

(12 reference statements)

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“…The nose region presents a greater thickness of these tissues, guaranteeing greater sustentation and, therefore, would not be a region with characteristics favorable for the formation of large pores (Contet-Audonneau et al, 1999; Pellacani and Seidenari, 1999). The greater amount of large pores in the malar region may also be related to structural factors, since the results obtained in the present study (Figure 4) and data reported in the literature, show that the epidermis has lower thickness in this region, which may favor larger pores (Murakami et al, 2006; Andrade et al, 2015). In addition, Kim et al (2011), evaluated the correlation of different parameters with the presence of pores and observed the relationship between a higher number of pores and lower skin elasticity, showing that a firmer and more structured skin may be related to a lower tendency of pore appearance.…”

Section: Resultssupporting

confidence: 62%

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

2019

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Excessively oily skin leads to clinical signs that cause discomfort to patients, such as excessive shine, enlarged pores, acne, and an imbalance of the hydrolipidic layer. In this context, a constant demand for the research and development of products that prevent these features, has been noted in the field of cosmetics and dermatology. Thus, the objective of this study is to evaluate the cutaneous characteristics of oily skin due an excessive production of sebum through biophysical and skin imaging techniques. 19 participants with different skin types were selected and the following parameters were evaluated: pore count, determination of the number of sebaceous glands and amount of sebum in infundibulum, determination of cutaneous microrelief, count of comedones, evaluation of epidermis thickness, characterization of the cellular, and comedone size and its characteristics. These evaluations were done through biophysical and skin imaging techniques. The obtained results showed that different regions of the face presented different characteristics related to oiliness, quantity, and the appearance of pores and comedones. The malar region had a lower epidermis thickness and a larger number of large pores. Moreover, in this region excessive sebum production, which can be related to pores, not comedones, was noted. The nose region presented higher sebum content in the infundibulum and lower active sebaceous glands, showing a higher activity of sebaceous production in this region. The chin region presented a positive correlation between the sebum content, roughness parameter and the number of pores and comedones. As different skin properties are related and influence the appearance of undesirable clinical signs, we identified the need for a multifactorial approach for the effective treatment of oily skin. The rational development of multifunctional cosmetic products that promote the control of oily skin, that regulate the keratinization process, improve the microrelief and leads to a better epidermis and dermis structure, will not only improve oily skin conditions but will also allow for the reduction or disappearance of clinical signs that result from excessive oiliness, all of which causes concern and results in a relentless search for cosmetic and dermatological products that address the unaesthetic nature of these conditions.

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Section: Resultssupporting

confidence: 62%

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

2019

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“…In a recent study by Pellacani et al ., a series of dermoscopic features in 202 melanocytic lesions have been evaluated and correlated with their histopathological and confocal microscopic findings . In 2014, Rstom et al ., described the correlation between some dermoscopic findings and histopathological ones in melanoma using the reflectance confocal microscopy (RCM) evaluation …”

Section: Introductionmentioning

confidence: 99%

“…9 In 2014, Rstom et al, described the correlation between some dermoscopic findings and histopathological ones in melanoma using the reflectance confocal microscopy (RCM) evaluation. 10 Nowadays, in vivo RCMby producing horizontal images like dermoscopyis most likely the best method to link dermoscopic to histopathological findings, even more if associated with the punch technique.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopy pathology correlation in melanoma

Russo

Piccolo

Ferrara

et al. 2017

The Journal of Dermatology

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“…230 On the other hand, studies in human skin show that photolyase topical application induces dimer reversion and leads to immunoprotection. 231,232 The possibility of incorporating photolyase into a sunscreen and therefore repair DNA photodamage is exciting; in the words of Stege et al 'Exogenous application of photolyase differs from conventional photoprotection through its ability to remove damage that has already occurred. This enzyme therapy approach could thus be ideally combined as an after-sun strategy with conventional sunscreens to provide photoprotection and repair at the same time'.…”

Section: Photolyasementioning

confidence: 99%

Enzymes for dermatological use

Nascimento,

Torres‐Obreque,

Oliveira

et al. 2024

Experimental Dermatology

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Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti‐ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.

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Reflectance confocal microscopy of cutaneous melanoma. Correlation with dermoscopy and histopathology

Cited by 7 publications

References 10 publications

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

Use of Advanced Imaging Techniques for the Characterization of Oily Skin

Dermoscopy pathology correlation in melanoma

Enzymes for dermatological use

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