Dermoscopy pathology correlation in melanoma

Russo, Teresa; Piccolo, Vincenzo; Ferrara, Gerardo; Agozzino, Marina; Alfano, Roberto; Longo, Caterina; Argenziano, Giuseppe

doi:10.1111/1346-8138.13629

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…Dermoscopy enables the clinician to examine plural diagnostic features in different skin lesions, which are normally impossible to detect with the naked eye. As a vastly researched technique it is known to have a high specificity of ≈ 65-90% and sensitivity evaluated as ≈ 65-90% [9][10][11] if performed by a well-experienced clinician [7,12].…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic features in different dermatopathological stages of cutaneous melanomas

Podolec¹,

Bronikowska²,

Pirowska³

et al. 2020

pdia

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Introduction: Due to the rising incidence of cutaneous melanoma there is a great need for the development of new diagnostic techniques as well as the improvement of those that are already well known, such as dermoscopy. Since early detection and a proper technique for excising the tumor are crucial for patients' survival, early staging of the tumor is very important. Aim: To investigate whether there is a significant difference between the presence of selected dermoscopic features compared to the location on the skin and pathology results: Breslow's depth, mitotic index and ulceration. Material and methods: We examined videodermoscopic images of cutaneous melanomas in 81 patients and compared their features with the histological results such as Breslow's depth, mitotic index and ulceration. In the study, we divided and compared the tumors in groups: in situ and invasive, ≤ 1.0 mm and > 1.0 mm thick on the Breslow scale. Results: In the study we observed statistically significantly higher prevalence of pseudopods (30.5%) and multicomponent pattern (69.5%) in invasive melanomas in comparison to in situ melanomas (9.1% and 36.4% respectively). White regression structures were more commonly described in invasive melanomas thicker than 1.0 mm on Breslow's scale. Atypical blood vessels and nodules were more specific to invasive melanomas with ulcerations and mitotic index ≥ 1. The atypical pigment network was more specific for thin invasive melanomas. Conclusions: Presence of pseudopods, a multicomponent pattern, white regression structures, atypical blood vessels and nodules on dermoscopy suggest invasive (high stage) melanoma.

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Section: Introductionmentioning

confidence: 99%

Dermoscopic features in different dermatopathological stages of cutaneous melanomas

Podolec¹,

Bronikowska²,

Pirowska³

et al. 2020

pdia

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“…Melanoma, one of the most aggressive and treatment-resistant type of skin cancer, develops from melanocytes, specialized pigmented cells that reside underneath the epidermis 1 . Current treatment strategies for melanoma patients include surgical resection, chemotherapy and radiation therapy 2 .…”

Section: Introductionmentioning

confidence: 99%

Down-regulation of GADD45A enhances chemosensitivity in melanoma

Liu

Jiang

Mao

et al. 2018

Sci Rep

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Melanoma is a malignant skin cancer with considerable drug resistance. Increased expression of DNA repair genes have been reported in melanoma, and this contributes to chemotherapy resistance. GADD45A is involved in DNA repair, cell cycle arrest and apoptosis in response to physiologic or environmental stresses. In this study, we investigated the role of GADD45A in chemotherapy response. Firstly, the mRNA expression of profiled DNA repair genes in cisplatin-treated melanoma cells was detected by RT2 profilerTM PCR array. We found the expression of GADD45A upregulated in a dose- and time- dependent manner. In addition, suppression of GADD45A sensitized melanoma cells to cisplatin and enhanced cisplatin-induced DNA damage. Flow cytometry revealed that downregulating GADD45A released cells from cisplatin-induced G2/M arrest and increased apoptosis. By using a MEK inhibitor, GADD45A was shown to be regulated by MAPK-ERK pathway following cisplatin treatment. Thus, the induction of GADD45A might play important roles in chemotherapy response in human melanoma cancer and could serve as a novel molecular target for melanoma therapy.

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“…Corresponding to these distinctive dermoscopic findings, histopathologically, in ALM in situ, solitary arranged melanocytes are mainly observed in the epidermal rete ridges underlying the surface ridges (Fig. 13c), [54][55][56] while, in acral nevus, nests of melanocytes are mainly detected in the rete ridges underlying the surface sulci (Fig. 13d).…”

Section: Biologic Significance Of the Dermoscopic Parallel Ridge Pattmentioning

confidence: 90%

Histogenesis of cutaneous malignant melanoma: The vast majority do not develop from melanocytic nevus but arise de novo as melanoma in situ

Saida

2019

The Journal of Dermatology

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It has been considered that most cutaneous malignant melanomas arise from pre‐existing melanocytic nevus. Many clinical and histopathological studies seem to support this concept. Dysplastic nevus originally proposed by Clark's group is a key entity of the intermediate lesion between benign nevus and melanoma. The latest edition of the WHO Classification of Skin Tumours (2018) has excluded Clark nevus (dysplastic nevus of mild atypia) from dysplastic nevus, the latter being now classified into the low‐ and high‐grade by the degrees of nuclear atypia. The World Health Organization classification regards dysplastic nevus of both grades as the intermediate lesion between common acquired nevus and the radial growth‐phase melanoma. An extensive genetic study recently performed by Bastian's group indicated the existence of intermediate lesions between nevus and melanoma. In spite of these findings, some investigators doubt the concept of the intermediate lesions including dysplastic nevus and insist that the majority of melanomas arise de novo as melanoma in situ, not in association with a preceding nevus. The concept of de novo genesis of melanoma may be supported by a recent meta‐analysis study revealing that 71% of melanomas likely arose de novo and 29% from pre‐existing nevus. In this review article, from the viewpoint of de novo genesis of melanoma, the author critically discusses the relevant findings of melanoma genesis and proposes a new framework to interpret the morphological and genetic data alternatively. Clarification of the oncogenic process of melanoma has great impact not only on clinical dermatology but also on basic oncology.

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Dermoscopy pathology correlation in melanoma

Cited by 27 publications

References 25 publications

Dermoscopic features in different dermatopathological stages of cutaneous melanomas

Dermoscopic features in different dermatopathological stages of cutaneous melanomas

Down-regulation of GADD45A enhances chemosensitivity in melanoma

Histogenesis of cutaneous malignant melanoma: The vast majority do not develop from melanocytic nevus but arise de novo as melanoma in situ

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