Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis

Veronez, Isis Suga; Dantas, Fernando Luiz Teixeira; Valente, Neusa Yuriko Sakai; Kakizaki, Priscila; Yasuda, T; Cunha, Thais do Amaral Carneiro

doi:10.1590/abd1806-4841.20153263

Cited by 16 publications

(29 citation statements)

References 8 publications

(12 reference statements)

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“…Close differentials to IGD include Palisaded Neutrophilic and Granulomatous Dermatitis (PNGD), Granuloma annulare (GA); others are rheumatoid nodules, rheumatoid vasculitis, Lichen planus, erythema multiforme, erythema elevatum diutinum, erythema chronicum migrans, early inflammatory stage of morphea and interstitial granulomatous drug eruption. 2,5 Table 2 describes the differentiating features between IGD, PNGD, and GA. 2,6 There is no specific therapy for interstitial granulomatous dermatitis. In case if it is drug induced, withholding the offending drug may result in resolution of the skin lesions.…”

Section: Discussionmentioning

confidence: 99%

“…It may also manifest as erythematous and violaceous papules, patches, nodules, plaques, annular lesions, and at different body sites. 2,3 It is described to be associated with many auto immune disorders, drugs and malignancies. In this case report we describe a 67-yearold gentleman, a known case of Rheumatoid arthritis (RA), strongly seropositive for RA Factor and Anti-CCP.…”

Section: Introductionmentioning

confidence: 99%

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Interstitial granulomatous dermatitis: a rare case report of dermatological manifestation of rheumatoid arthritis

Chandrasekaran

Alex

2020

Int J Res Med Sci

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Interstitial granulomatous dermatitis (IGD), a rare dermatological disorder was first described by Ackerman et al, in the year 1993. It is characterized by a heterogeneous clinical spectrum and a specific histopathological pattern. It has been described in association with a number of auto-immune disorders, drugs, fungal infections, and malignancies. It may manifest as papules, patches, plaques, nodules, annular lesions, or less frequently, as described classically, as indurated linear subcutaneous cords. This case is being reported as interstitial granulomatous dermatitis is rare dermatological manifestation of rheumatoid arthritis and presentation as large ulcerated skin lesions is further extremely rare. In this case report we describe a 67-year-old gentleman with Seropositive Rheumatoid arthritis. He presented to our hospital with complaints of multiple well defined skin lesions with pus discharge over lower limbs, trunk and upper limbs. Biopsies from left upper limb and abdomen showed focal necrobiosis with surrounding granulomatous inflammation with rare perivascular granulomas. He was subsequently diagnosed to have interstitial granulomatous dermatitis based on histopathological examination. Interstitial granulomatous dermatitis has been described to be associated with a number of autoimmune conditions and drugs. It is very important for clinicians to have knowledge about this rare skin condition as it may be heralding presentation of a serious underlying condition like lymphoproliferative disorders or solid organ malignancies. There is no specific treatment and causative disease has to be diagnosed and targeted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interstitial granulomatous dermatitis: a rare case report of dermatological manifestation of rheumatoid arthritis

Chandrasekaran

Alex

2020

Int J Res Med Sci

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“…Its prognosis is favorable with two-thirds of patients experiencing spontaneous remission after 3 months to 3 years23456.…”

Section: Discussionmentioning

confidence: 99%

“…Histological feature of IGD is interstitial infiltrate of histiocytes in the reticular dermis. IGD is associated with various systemic conditions, such as arthritis, autoimmune disease, connective tissue disease, and internal malignancy 2 3 4 5 6 . We describe a rare case of IGD associated with prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer

et al. 2017

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Interstitial granulomatous dermatitis (IGD) is a rare dermatosis, histologically characterized by an interstitial granulomatous infiltrate. It is associated with inflammatory arthritis, various medications, and autoimmune conditions. It is also associated with malignancies such as breast, endometrial, lung, and esophageal cancers as well as hematologic malignancies such as lymphoma and myelodysplastic syndrome. Herein we describe a case of IGD associated with prostate cancer, which has not been reported in the literature.

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“…3-5 In this patient's case, joint involvement was investigated, thus excluding, initially, the diagnosis of autoimmune disease and drugs as causal factors.…”

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confidence: 99%