Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer

Abstract

Interstitial granulomatous dermatitis (IGD) is a rare dermatosis, histologically characterized by an interstitial granulomatous infiltrate. It is associated with inflammatory arthritis, various medications, and autoimmune conditions. It is also associated with malignancies such as breast, endometrial, lung, and esophageal cancers as well as hematologic malignancies such as lymphoma and myelodysplastic syndrome. Herein we describe a case of IGD associated with prostate cancer, which has not been reported in the literature.

Interstitial Granulomatous Dermatitis and Palisaded Neutrophilic Granulomatous Dermatitis: Retrospective Clinicopathological Analysis of 16 cases

“…In our series, the patient with PNGD was accompanied by autoimmune hepatitis. In literature, other diseases which may accompany were autoimmune disorders such as; rheumatoid arthritis [ 3 , 4 ], systemic lupus erythematosus [ 1 , 3 , 4 , 16 ], autoimmune thyroiditis, primary biliary cirrhosis [ 7 ], malignancies such as hematological or solid cancers [ 14 , 15 ], infections such as HCV and related cryoglobulinemia [ 10 ], coccidiomycosis [ 17 ] or medications [ 4 , 5 ]. In 31.2% of patients, there were no associated autoimmunity or malignancy despite of clinical and laboratory evaluation for an underlying disorder.…”

“…In our study, autoimmunity PNGD was accompanied by autoimmune hepatitis. In literature, other diseases which may accompany were autoimmune disorders such as; rheumatoid arthritis [3,4], systemic lupus erythematosus [1,3,4,16], autoimmune thyroiditis, primary biliary cirrhosis [7], malignancies such as hematological or solid cancers [14,15], infections such as HCV and related cryoglobulinemia [10], coccidiomycosis [17] or medications [4,5] Angiotensin receptor antagonists, thiazide diuretics, calcium channel blockers are thought to be associated with interstitial granulomatous drug reaction [3]. Like mentioned in methods, interstitial granulomatous drug reaction was excluded from the study.…”

Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Behçet's Disease: A Case Report

“…Rarely, neutrophils and eosinophils can be found and vasculitis is generally absent. IGD is associated with various systemic conditions and medications such as antihypertensives, lipid-lowering agents, and anticonvulsants 14 . Considering the overlapping clinical and histopathologic findings and systemic disease associations, IGD and PNGD are thought to exist on the same clinicopathological spectrum while others have considered that IGD has a distinct clinical presentation with associated histopathology 15 16 .…”

“…It might be difficult to differentiate IGD from interstitial granuloma annulare (IGA) which show interstitial granulomatous pattern. In IGA, prominent mucin deposition and focal histiocytic infiltrates are observed 14 . In our case, based on the patient's medical history, she did not take any medications known to be associated with the development of granulomatous dermatitis 14 15 .…”

“…In IGA, prominent mucin deposition and focal histiocytic infiltrates are observed 14 . In our case, based on the patient's medical history, she did not take any medications known to be associated with the development of granulomatous dermatitis 14 15 . The histopathologic features displayed a fully developed lesion of PNGD.…”