Comorbidities and cardiovascular risk factors in patients with psoriasis

Baeta, Isabela Guimarães Ribeiro; Bittencourt, Flávia Vasques; Goulart, Eugênio Marcos Andrade

doi:10.1590/abd1806-4841.20142874

Cited by 42 publications

(46 citation statements)

References 37 publications

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“…The prevalence of MetS in the present study was 50.0%. A single center study carried out by Baeta et al . in the southeastern region of Brazil ( n = 190 patients with PsO) observed a 44.9% prevalence of MetS, similar to our study.…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence of MetS in the present study was 50.0%. A single center study carried out by Baeta et al 41 in the southeastern region of Brazil (n = 190 patients with PsO) observed a 44.9% prevalence of MetS, similar to our study. A case-control Brazilian study investigated research questions similar to ours regarding PsO comorbidities, specifically, the frequency of hypertension and MetS.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Metabolic syndrome and psoriatic arthritis among patients with psoriasis vulgaris: Quality of life and prevalence

Souza

Castro

Carneiro

et al. 2018

The Journal of Dermatology

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Interest has increased in comorbidities associated with psoriasis and their effects on health‐related quality of life (HRQoL). This study aimed to evaluate the prevalence of metabolic syndrome (MetS) and psoriatic arthritis (PsA) and to investigate HRQoL and the prevalence of hypertension, type 2 diabetes mellitus (T2DM), obesity and dyslipidemia. In a cross‐sectional design, patients diagnosed with plaque psoriasis answered an interview and standardized questionnaires (Dermatology Life Quality Index questionnaire [ DLQI ], 36‐Item Short Form Health Survey [SF‐36] and EuroQol Five‐Dimension Questionnaire Three‐Level version [ EQ ‐5D‐3L]). Physical examination and several tests to assess desired outcomes were performed by a dermatologist and a rheumatologist during three visits. The prevalence of MetS and PsA was 50.0% and 41.8%, respectively. Dyslipidemia was the most prevalent (74.5%) secondary comorbidity, followed by hypertension (61.8%), obesity (52.5%) and T2DM (30.9%). The mean (standard deviation) DLQI score was 6.5 (6.9), and mean physical and mental SF‐36 measures were 45.2 (10.4) and 45.5 (12.3), respectively, and for EQ‐5D‐3L, mean utility index and EQ ‐ VAS scores were 0.68 (0.27) and 72.7 (19.7), respectively. PsA and MetS are important comorbidities; a reduced HRQoL is noted among plaque psoriasis patients with these comorbidities, emphasizing the relevance of diagnosis and treatment beyond the care of skin lesions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Metabolic syndrome and psoriatic arthritis among patients with psoriasis vulgaris: Quality of life and prevalence

Souza

Castro

Carneiro

et al. 2018

The Journal of Dermatology

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“…In some studies, the risk of CVD has been reported to be higher in patients with psoriasis. 1 , 5 , 9 – 17 However, in some other reports in overall examination and considering the whole psoriatic patients the risk of CVD, transient ischemic attacks, or cerebrovascular accidents remained unchanged between psoriatic patients and controls. 18 Furthermore, no association between psoriasis and metabolic syndrome has been observed in Korean psoriatic patients.…”

Section: Introductionmentioning

confidence: 88%

Associations between cardiovascular risk factors and psoriasis in Iran

Farshchian¹,

Ansar²,

Sobhan³

2015

CCID

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BackgroundPsoriasis is a common chronic inflammatory skin disease. There is overwhelming evidence on the higher risk of cardiovascular diseases in patients with psoriasis as a result of hyperlipidemia, which is more common in these patients.ObjectivesThe aim of this study was to elucidate the association between the cardiovascular risk factors and psoriasis.MethodsIn a cross-sectional study, 55 patients with psoriasis and 55 matched (sex and age) controls were entered the study at the Department of Dermatology between March 2011 and March 2013. Blood samples were obtained following 14 hours fasting status and serum levels of triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein were determined using standard laboratory methods, and other variables such as sex, age, smoking, alcohol consumption, and the type of disease were recorded.ResultsOur findings showed that levels of triglyceride, low-density lipoprotein, and smoking were significantly higher in psoriatic patients when compared with controls, whereas the level of high-density lipoprotein and cholesterol was not significantly different between two groups. Body mass index of psoriatic patients was not significantly higher than controls. Patients with psoriasis also had an increased prevalence of hypertension.ConclusionOur findings further verify lipid abnormalities in psoriatic patients. Psoriasis is associated with higher rate of hypertension, which may be resulted in increasing the risk of cardiovascular diseases in these patients. Thus, serum lipid profile and blood pressure in all patients with psoriasis, regardless of disease severity, deserve consideration to be checked.

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“…The impact on the quality of life may cause depression, which in turn negatively affects adherence to treatment. Based on a meta-analysis, the prevalence of depression in patients with psoriasis is 20-30% [3,29]. Severity of psoriasis was unrelated to depression risk [17].…”

Section: Expert Opinionmentioning

confidence: 99%