Metabolic syndrome and psoriatic arthritis among patients with psoriasis vulgaris: Quality of life and prevalence

Abstract

Interest has increased in comorbidities associated with psoriasis and their effects on health‐related quality of life (HRQoL). This study aimed to evaluate the prevalence of metabolic syndrome (MetS) and psoriatic arthritis (PsA) and to investigate HRQoL and the prevalence of hypertension, type 2 diabetes mellitus (T2DM), obesity and dyslipidemia. In a cross‐sectional design, patients diagnosed with plaque psoriasis answered an interview and standardized questionnaires (Dermatology Life Quality Index questionnaire [ DLQI ], 36‐Item Short Form Health Survey [SF‐36] and EuroQol Five‐Dimension Questionnaire Three‐Level version [ EQ ‐5D‐3L]). Physical examination and several tests to assess desired outcomes were performed by a dermatologist and a rheumatologist during three visits. The prevalence of MetS and PsA was 50.0% and 41.8%, respectively. Dyslipidemia was the most prevalent (74.5%) secondary comorbidity, followed by hypertension (61.8%), obesity (52.5%) and T2DM (30.9%). The mean (standard deviation) DLQI score was 6.5 (6.9), and mean physical and mental SF‐36 measures were 45.2 (10.4) and 45.5 (12.3), respectively, and for EQ‐5D‐3L, mean utility index and EQ ‐ VAS scores were 0.68 (0.27) and 72.7 (19.7), respectively. PsA and MetS are important comorbidities; a reduced HRQoL is noted among plaque psoriasis patients with these comorbidities, emphasizing the relevance of diagnosis and treatment beyond the care of skin lesions.

Secukinumab for Psoriasis in Obese Patients: Minireview and Clinical Experience

“…Psoriatic arthritis and metabolic syndrome are common comorbidities in patients with psoriasis; their frequency presents a wide variation depending on population groups observed. In a recent publication by Souza et al [1], the authors stated that among comorbidities associated with psoriasis and strictly related to the patient's quality of life, the prevalence of metabolic syndrome and psoriatic arthritis was 50 and 41.8%, respectively. Dyslipidemia was the most prevalent secondary comorbidity, followed by hypertension, obesity, and type 2 diabetes mellitus.…”

Interleukin-17A and Keratinocytes in Psoriasis

“…Males are twice as likely as females to be affected [3,4]. As desquamative erythema can affect any skin site, psoriasis profoundly impairs the patients' quality of life, treatment satisfaction and adherence, and socioeconomic stability [5][6][7]. The skin lesion usually appears on the sites with frequent trauma such as elbows and knees [8,9].…”

Benefits of Hesperidin for Cutaneous Functions

“…In addition to their psychosocial impact and the quality of life for affected patients and their families, certain chronic cutaneous disorders can also contribute to the development of other systemic diseases. For example, both psoriasis and eczematous dermatitis increase circulating levels of proinflammatory cytokines [8–10], which appear to play a pathogenic role in the development of cardiovascular diseases, obesity, type II diabetes, and Alzheimer's disease [11–14]. Because of its vast size, even subclinical inflammation in the skin can dramatically increase serum cytokine levels, which could be linked to some of these age-associated disorders [12, 15].…”