Comparação entre duas técnicas de genotipagem do HPV em mulheres com lesão intra-epitelial de alto grau

Serravalle, Karina; Levi, José Eduardo; Oliveira, Cristina Mendes de; Queiroz, Conceição; Dantas, Ádila; Studart, Eduardo

doi:10.1590/so100-720320150005206

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…This set of techniques is highly sensitive and can specifically identify the presence of virus in the host, even in its latent state 4 . The type discrimination of HPV in clinical materials from the genital mucosa is important since it is possible to identify whether it will form high or low-grade lesions for the development of cancer 10 . Therefore, HPV type analysis has the potential to assist in the conduct of a more appropriate treatment, avoiding more invasive procedures in the patient.…”

Section: Introductionmentioning

confidence: 99%

Potential Diagnostic Techniques for Cervical Cancer Prevention - Review

Melo¹,

Ribeiro²,

Canevari³

2018

J Cancer Treat & Diagnosis

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Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide and several studies have proven the close relationship between HPV and the development of cervical cancer. Several tests are currently performed for early and reliable diagnosis, in which the cervical cytology evaluation by the Papanicolaou method is highlighted. However, errors in the collection and misinterpretation of cell differentiation degree in smear by the pathologist result in incorrect or inaccurate results. Considering these points, it is of utmost importance to develop new technologies that perform accurate and reliable diagnosis and that present financial advantages and accessibility. Currently, molecular biology assays are excellent detectors of viral DNA, but it presents disadvantages, such as the need for high financial resources to gain access. Therefore, this review has the objective of highlighting the main diagnostic techniques that are already being used, such as specific kits for the detection of high-risk HPVs, or methodologies that are still in the study phase, but which already present good results, such as the application of physical FTIR spectroscopy principles and ultrasensitive biosensors.

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Section: Introductionmentioning

confidence: 99%