volume 49, issue 2, P359-366 2013
DOI: 10.1590/s1984-82502013000200018
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Abstract: Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in tablets (Xarelto ® (10 mg)). Phenomenex Luna 5 µm C18 100 Å LC Column (250 x 4.6 mm) was used at 40 o C. Isocratic elution was performed with ACN:Water (55:45 v/v) mixture. The flow rate was 1.2 mL min -1 and UV detection was at 249 nm. Internal standard (Caffeine) and rivaroxaban were eluted …

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